5-bromo-2-hydroxy-4-methyl-3-nitropyridine

5 + -Hydroxy-2-furyl-4-methyl-3-pyridyl formaldehyde, which has a wide range of uses. In the field of medicine, it is a key intermediate. Gein has a unique chemical structure and can participate in many drug synthesis reactions, laying the foundation for the creation of new drugs. For example, when developing therapeutic drugs for specific diseases, it is often used as a starting material through a series of organic synthesis steps to gradually construct complex molecular structures with specific pharmacological activities.
In the field of materials science, it also has important value. It can be used as a synthetic raw material for functional materials, chemically modified and assembled to prepare materials with special optical, electrical or magnetic properties. For example, by copolymerizing or compounding with other organic or inorganic compounds, materials with excellent luminescence properties may be obtained for use in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) to improve their luminous efficiency and stability.
In the field of fine chemicals, it is also an indispensable component. It can be used to prepare fine chemicals such as high-grade fragrances and dyes. Due to its unique chemical structure, the product has unique properties. In fragrance synthesis, it can add unique odor characteristics to fragrances; in dye synthesis, it can affect the color, fastness and other properties of dyes, so as to meet the diverse needs of different industries for fine chemicals.

To prepare 5-bromo-2-naphthyl-4-methyl-3-pyridinone, there are many ways to synthesize it.
First, it can be obtained by substitution reaction between suitable naphthyl derivatives and pyridinone precursors under suitable reaction conditions. For example, a specific halogenated naphthalene is selected to be substituted with the pyridinone structural unit containing the corresponding substituent, under the action of base and catalyst, to promote the substitution of the halogen atom with the active check point of the pyridinone, and then to construct the target structure. The base can be selected from potassium carbonate, sodium carbonate, etc. The catalyst is selected as the situation, such as palladium catalysts, etc. The solvent is commonly used N, N-dimethylformamide, dichloromethane, etc., through precise regulation of the reaction temperature and time, the yield of the product is improved.
Second, the strategy of gradually constructing the ring system is done. First synthesize the pyridinone ring containing a partial substituent, and then introduce the naphthyl fragment. For example, prepare the specific substituted pyridinone first, and then react with the naphthylation reagent through suitable reaction conditions, or through the Fu-gram reaction, etc., to realize the connection between the naphthyl group and the pyridinone ring, and then introduce the bromine atom as required. When introducing bromine atoms, brominating agents can be selected according to specific circumstances, such as liquid bromine, N-bromosuccinimide, etc., and the bromine atoms can be precisely placed at the target position under suitable reaction environments.
Third, it can also be achieved from the raw material through multi-step functional group conversion and cyclization reaction. First, the starting material is modified by functional groups to generate intermediates containing specific active groups, and then through intramolecular cyclization to construct pyridinone rings, and at the same time, naphthyl and methyl substituents are ingeniously introduced. During the whole process, the reaction conditions of each step, such as temperature, pH, and the ratio of reactants, need to be strictly controlled to ensure that the reaction proceeds according to the predetermined path and improve the purity and yield of the target product. After each step of the reaction, it is advisable to remove impurities by suitable separation and purification methods, such as column chromatography, recrystallization, etc., to provide a pure intermediate for the subsequent reaction, and finally complete the synthesis of 5-bromo-2-naphthyl-4-methyl-3-pyridone.

The physical properties of 5 + -hydroxy-2-furyl-4-methyl-3-pyridyl are as follows:
This compound is either a solid or a liquid with certain volatility at room temperature. The specific properties are affected by the intermolecular forces and structures. Its melting point is closely related to the intermolecular binding force. Due to the existence of a variety of polar groups and relatively complex structures, the intermolecular forces are strong. The estimated melting point or in a relatively high temperature range requires a certain amount of energy to overcome the lattice energy before melting. The boiling point is also high. To transform it from a liquid state to a gaseous state, more energy needs to be supplied to break the intermolecular forces. < Br >
In terms of solubility, because it contains polar groups such as hydroxyl (-OH), it may have a certain solubility in polar solvents such as water, and can interact with water molecules to form hydrogen bonds to increase the degree of solubility; while in non-polar solvents such as n-hexane, the solubility may be limited due to the weak force between polar groups and non-polar solvent molecules.
The density is determined by its relative molecular weight and the degree of molecular packing compactness. In view of the molecular structure containing multiple atoms and specific functional groups, the relative molecular weight is large, and the molecular arrangement or relatively close, and the density may be higher than that of common organic solvents, which is similar to that of some medium-density organic compounds.
In addition, the compound contains a conjugated system or has certain optical properties. For example, under the irradiation of specific wavelengths of light, it can exhibit optical phenomena such as absorption and emission. The specific optical parameters are related to the degree of conjugation and the molecular environment. And due to the existence of multiple functional groups, its infrared spectrum and other spectral characteristics are significant, which can provide a basis for identification and analysis.

The chemical properties of 5 + -hydroxyl-2-furanyl-4-methyl-3-pyridyl groups are as follows:
This compound has unique chemical properties due to its various functional groups. Its hydroxyl group (-OH) has active properties and can participate in many reactions. Hydroxyl groups can undergo substitution reactions, such as with halogenated hydrocarbons under basic conditions, hydroxyl hydrocarbons are replaced by hydrocarbon groups to form corresponding ether compounds. At the same time, hydroxy groups can participate in esterification reactions, form ester bonds with carboxylic acids under concentrated sulfuric acid catalysis and heating conditions, and produce ester substances. This reaction is often used in organic synthesis to prepare specific ester products.
Furanyl, as a five-membered heterocyclic structure, has aromatic properties. Due to the special distribution of electron clouds on the ring, electrophilic substitution reactions are prone to occur. For example, in halogenation reactions, halogen atoms can replace hydrogen atoms on the furan ring. The reaction can usually be carried out under mild conditions, and the reaction check point has a certain selectivity, which mostly occurs at the α-position.
methyl groups are attached to the molecular structure and are relatively stable, but under the action of strong oxidants, methyl groups can be oxidized. For example, in hot acidic potassium permanganate solutions, methyl groups can be gradually oxidized to carboxyl groups (-COOH), which can be used in organic synthesis to introduce carboxyl functional groups and expand the reactivity and application range of molecules.
The pyridyl group is a nitrogen-containing six-membered heterocycle, and the presence of nitrogen atoms makes the pyridyl ring basic. The pyridyl group in this compound can react with acids to form pyridyl salts. This property is widely used in medicinal chemistry, which can improve the solubility and stability of drugs through salt-forming reactions. At the same time, the pyridyl ring can also undergo electrophilic substitution reactions, but due to the electronegativity of nitrogen atoms, the reactivity is lower than that of the benzene ring, and the reaction check point is mostly at the β-position.
In summary, the 5 + -hydroxyl-2-furyl-4-methyl-3-pyridine gene has various functional groups that interact with each other, presenting rich and diverse chemical properties, and has important application value in organic synthesis, drug development and other fields.

The item that the viewer is looking for is called 5 + -bromo-2-furanyl-4-methyl-3-pyridyl. This is a fine chemical that is difficult to determine at the price range of the market. The price is influenced by many factors, such as the abundance of raw materials, the difficulty of preparation, the amount of demand, and the competitive situation of the market.
If the raw materials are plentiful and easy to obtain, the preparation process is mature, the cost is controllable, and the market demand is not extremely strong, and there are many competitors, the price may be stable and relatively low. On the contrary, if the raw materials are scarce and rare, the preparation requires complicated processes and consumes huge resources, and the market demand is strong, the supply is in short supply, and the price will rise.
Although it is difficult to determine the exact price range, it is common sense that in the field of fine chemicals, if such chemicals are of ordinary quality, the price per gram may be between tens of yuan and hundreds of yuan. If there are strict requirements for purity, impurity content, etc., those who reach high purity and ultra-clean grade, the price per gram may climb to thousands of yuan or even higher. However, this is only the number of ideas, and the real price needs to be carefully examined in the current chemical market supply and demand conditions and the quotations of various suppliers to obtain an accurate number.