5-Bromo-2-hydroxy-3-methylpyridine

5-Bromo-2-hydroxy-3-methylpyridine is a kind of organic compound. It has specific physical properties and is very important in the field of organic synthesis.
Looking at its properties, under normal temperature, it is mostly in a solid state. The melting point of this substance is about a certain range, and the specific value may vary due to factors such as measurement conditions. The melting point is the temperature at which a substance changes from a solid state to a liquid state. It is a key indicator when identifying and purifying the compound.
Discusses solubility, which has a certain solubility in common organic solvents such as ethanol and dichloromethane. However, the solubility in water is relatively low. This solubility characteristic is related to the molecular structure. The molecule contains polar hydroxyl groups, which increases its interaction with polar solvents. At the same time, non-polar groups such as bromine and methyl affect its dissolution in water. In organic synthesis reactions, this solubility property helps to select an appropriate reaction solvent and promote the smooth progress of the reaction.
The boiling point of 5-bromo-2-hydroxy-3-methylpyridine is also an important physical property. The boiling point is the temperature at which the saturated vapor pressure of a liquid is equal to the ambient atmospheric pressure. Knowing its boiling point is of great significance for operations such as distillation and separation, which can help to precisely control conditions and achieve effective separation and purification of compounds.
In addition, its density is also one of the physical properties. Density refers to the mass of a unit volume of a substance. Although this value is rarely considered directly in the synthesis operation, it may have certain reference value in the storage, transportation and other links to help determine the packaging and transportation mode.
In summary, the physical properties such as melting point, solubility, boiling point and density of 5-bromo-2-hydroxy-3-methylpyridine are related to each other and affect their application in organic synthesis and other fields. It helps chemists to deeply understand the characteristics of the compound, and then reasonably apply it to various chemical processes.

5-Bromo-2-hydroxy-3-methylpyridine is one of the organic compounds. Its chemical properties are unique and worth exploring.
Discussing acidity, because it contains hydroxyl groups, affected by the electron effect of pyridine ring, hydroxyl hydrogen has a certain acidity and can react with bases. For example, when it meets sodium hydroxide, hydroxyl hydrogen can be replaced by sodium ions to generate corresponding sodium salts.
Besides nucleophilic substitution, bromine atoms, as an important functional group of this compound, have high activity. Under appropriate conditions, such as contact with nucleophilic reagents, such as sodium alcohols and amines, bromine atoms are easily replaced by nucleophilic reagents, thereby deriving new compounds. For example, when reacted with sodium methoxide, the bromine atom will be replaced by methoxy to form 5-methoxy-2-hydroxy-3-methylpyridine.
In addition, the pyridine ring of this compound also has special properties. Pyridine rings have certain aromatic properties and can undergo electrophilic substitution reactions. However, due to the presence of hydroxyl, methyl and bromine atoms on the ring, these substituents will affect the position and activity of the electrophilic substitution reaction. Hydroxyl group and methyl group can increase the electron cloud density of the pyridine ring, especially the electron cloud density of the hydroxyl o and para-sites. However, although the bromine atom is an electron-withdrawing group, its effect on the electron cloud density of the pyridine ring is relatively complex due to its conjugation effect. In general, electrophilic substitution reactions tend to occur in the hydroxyl o and para-sites.
In terms of redox reactions, this compound also exhibits specific properties. Hydroxyl groups can be oxidized under the action of appropriate oxidants, and the pyridine ring may also participate in the oxidation reaction under specific conditions; while in the presence of some reducing agents, the pyridine ring or bromine atom may be reduced. The chemical properties of 5-bromo-2-hydroxy-3-methylpyridine are rich and diverse, and it has great potential for application in the field of organic synthesis. Through in-depth understanding and clever application of its properties, many organic compounds with unique functions can be prepared.

The common synthesis methods of 5-bromo-2-hydroxy-3-methylpyridine generally include the following.
First, 3-methyl-2-hydroxypyridine is used as the starting material. First, it is reacted with appropriate brominating reagents, such as liquid bromine, N-bromosuccinimide (NBS), etc., under suitable reaction conditions. If liquid bromine is used, it can be carried out at low temperature in an organic solvent such as dichloromethane and catalyzed by a catalyst such as iron powder or iron tribromide. This is due to the high electron cloud density of the adjacent and para-position of the phenolic hydroxyl group, and the bromine atom is easy to attack the adjacent position of the phenolic hydroxyl group, thereby generating 5-bromo-2-hydroxy-3-methylpyridine.
Second, take 2,3-dimethylpyridine as the starting material. First oxidize it, and a suitable oxidant can be selected, such as potassium permanganate, potassium dichromate, etc., oxidize the 3-position methyl to carboxyl to obtain 2-methyl-3-pyridinecarboxylic acid. 5-Bromo-2-methyl-3-methylpyridine was synthesized by introducing bromine atom at ortho position of carboxyl group through halogenation reaction. Finally, 5-bromo-2-hydroxy-3-methylpyridine was synthesized by reducing carboxyl group to hydroxyl group by appropriate reducing reaction, such as using reducing agent such as lithium aluminum hydride. For example, under suitable catalyst and reaction conditions, pyridine rings are formed by cyclization of certain enamines and nitriles containing appropriate substituents, and the desired methyl, hydroxyl and bromine atoms are introduced. This process requires precise control of reaction conditions, including temperature, reaction time, and proportion of reactants, etc., to ensure the formation of the target product.
All this synthesis method has its own advantages and disadvantages, and it needs to be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of the reaction, and the cost.

5-Bromo-2-hydroxy-3-methylpyridine is useful in the fields of medicine, pesticides and materials.
In the field of medicine, it is a key organic synthesis intermediate. Chemists use it to construct a multi-component and complex drug molecular structure. For example, when developing new antibacterial drugs, 5-bromo-2-hydroxy-3-methylpyridine can be used as the starting material, and various active functional groups can be added through exquisite chemical reactions. The new compounds may have excellent antibacterial activity, which can break the cell wall and cell membrane of bacteria, block their metabolic process, and achieve the effect of sterilization and treatment.
In the field of pesticides, its role is also obvious. Based on this, high-efficiency insecticides can be created. Its molecular structure can precisely fit specific biological targets in insects, such as neurotransmitter receptors. Once bound, it disturbs the normal operation of the insect's nervous system, causing it to malfunction and die of paralysis, protecting crops from pests and ensuring abundant agricultural production.
As for the field of materials, it has emerged. In the preparation of optoelectronic materials, 5-bromo-2-hydroxy-3-methylpyridine can be introduced into polymer structures. In this way, the photoelectric properties of materials can be improved, such as improving electrical conductivity and light absorption efficiency. Using it to make organic Light Emitting Diode (OLED) can make the device more efficient and colorful, and is widely used in display screens to make the picture lifelike.
From this point of view, although 5-bromo-2-hydroxy-3-methylpyridine is small, it plays an extraordinary role in many fields and contributes to the development of various industries.

My question today is to inquire about the market price of 5-bromo-2-hydroxy-3-methylpyridine. However, the market price of this compound is difficult to generalize, due to the intertwined influence of many factors.
Its price is first affected by the difficulty of preparation. If the preparation method is complicated, requires multiple steps of reaction, consumes rare raw materials, or requires harsh reaction conditions, such as precise temperature, pressure and catalyst, the cost will be high, and the price will also rise. On the contrary, if the preparation is simple, the cost is controllable, and the price should be relatively close to the people.
The state of market supply and demand is also key. If this compound is in high demand in the fields of medicine, chemical industry, etc., but the supply is limited, the merchant may raise the price due to the shortage of supply; if the demand is low and the supply is excessive, the price will drop in order to seek sales.
Furthermore, the quality grade also affects the price. Those with high purity and few impurities are suitable for high-end scientific research or pharmaceutical manufacturing, and the price must be higher than that of ordinary grades.
According to past market conditions, the price of 5-bromo-2-hydroxy-3-methylpyridine may range from a few yuan to tens of yuan per gram. However, this is only a rough estimate. For the exact price, you should consult chemical raw material suppliers, chemical reagent sales platforms, etc. Due to the rapidly changing market, prices vary from time to time, so real-time inquiry is the way to obtain accurate prices.