5-Bromo-2-hydrazinopyridine

5-Bromo-2-hydrazinopyridine, this is also an organic chemical. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. Due to its unique structure, it can undergo various chemical reactions to construct complex drug molecular structures and help create new drugs.
In the field of materials science, it is also used. It can participate in the preparation of materials with special properties, such as optoelectronic materials. Due to the properties of bromine and hydrazine in the structure, or the unique optical and electrical properties of the material, it shows potential value in optoelectronic devices, such as organic Light Emitting Diode.
In addition, in the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use it to react with other organic reagents such as nucleophilic substitution and cyclization to synthesize various organic compounds with specific structures and functions, and expand the variety and application range of organic compounds. In short, 5-bromo-2-hydrazine pyridine has important uses in many scientific fields and promotes research and development in related fields.

The synthesis method of 5-bromo-2-hydrazinopyridine has been investigated in the past. One method can also start with 5-bromo-2-chloropyridine. First take an appropriate amount of 5-bromo-2-chloropyridine and place it in the reaction kettle. Dissolve it with an appropriate solvent, such as dimethylformamide. This solvent can provide a stable environment for the reaction. Then, add hydrazine hydrate. The molar ratio of hydrazine hydrate to 5-bromo-2-chloropyridine needs to be precisely prepared. Usually, an excess of hydrazine hydrate is appropriate, about 3-5 times the molar amount. Because hydrazine hydrate is both a reactant and can help the reaction proceed to the right. The reaction temperature is also critical, and it can be warmed to 80-100 ° C. In this temperature range, the molecular activity is enhanced and the reaction rate is accelerated. When stirred continuously for a few hours, about 3-6 hours, the two are fully reacted. After the reaction is completed, the reaction solution is cooled, the organic phase is extracted with a suitable organic solvent, such as ethyl acetate, and the organic phase is separated. It is then dried with anhydrous sodium sulfate to remove the moisture. Finally, the crude product was obtained by distillation under reduced pressure, removing the solvent, and purified by column chromatography. Silica gel was used as the stationary phase, and petroleum ether and ethyl acetate were mixed in a certain proportion as the mobile phase to obtain pure 5-bromo-2-hydrazinopyridine.
There is another way to use 5-bromo-pyridine-2-amine as the raw material. Mix 5-bromo-pyridine-2-amine with sodium nitrite and dilute hydrochloric acid at low temperature, about 0-5 ° C. During the reaction, sodium nitrite solution should be slowly added dropwise and stirred continuously to make the reaction proceed uniformly. After the diazotization reaction is completed, a diazonium salt solution is obtained. Subsequently, this solution is added dropwise to the hydrochloric acid solution of stannous chloride. Stannous chloride plays a reducing role and converts the diazonium group into a hydrazine group. During the reaction process, the temperature should be controlled near room temperature. After the reaction is completed, the pH value of the reaction solution is adjusted to be weakly alkaline, and it is extracted with an organic solvent. The follow-up treatment is as above. After drying, distillation, purification and other steps, 5-bromo-2-hydrazine pyridine can also be prepared. These two methods have their own advantages and disadvantages. In practical application, the selection should be considered according to factors such as the availability of raw materials, cost and product purity requirements.

5-Bromo-2-hydrazinopyridine, which is a common raw material and intermediate in organic synthesis. Its physical properties are quite unique and of great significance to the field of organic synthesis.
Looking at its appearance, it is often a white to light yellow crystalline powder, delicate and with a specific color. This appearance characteristic is quite critical in preliminary identification. Its melting point usually falls within a certain range, about 160-165 ° C. This fixed melting point is an important physical identification of the substance, which helps to accurately distinguish and detect purity.
Furthermore, 5-bromo-2-hydrazinopyridine also has characteristics in terms of solubility. In common organic solvents, such as methanol and ethanol, it exhibits a certain solubility and can be well miscible with these solvents to form a homogeneous system. This property facilitates its application in organic reactions, because many organic reactions need to be carried out in a solution environment. In water, its solubility is relatively weak, which also determines that it needs to be carefully considered in reactions involving aqueous systems.
In addition, 5-bromo-2-hydrazinopyridine has certain stability, but under certain conditions, such as high temperature, strong acid or strong base environment, its structure may change, resulting in chemical properties change. Therefore, it is necessary to pay attention to environmental factors when storing, usually in a cool, dry and well-ventilated place to prevent deterioration.
These physical properties are essential for organic synthesis practitioners. Familiarity with and good use of these properties can enable them to be proficient in synthesis reaction design, operation and product purification, and promote efficient and accurate organic synthesis work.

5 - Bromo - 2 - hydrazinopyridine is an organic compound, and its chemical properties are worth exploring. In this compound, bromine atoms are connected to hydrazine and pyridine rings, giving it unique properties.
In terms of reactivity, bromine atoms can be used as good leaving groups for nucleophilic substitution reactions due to their strong electronegativity. In the presence of suitable nucleophiles, nucleophilic substitution is prone to occur. For example, when reacting with nucleophiles such as alcohols and amines, corresponding substitution products can be formed, thereby constructing diverse pyridine derivatives, which is of great significance in the field of organic synthesis.
Furthermore, hydrazine is also an active functional group. It can participate in condensation reactions, such as reacting with aldose and ketone to form hydrazone compounds. Such reactions are often used to prepare organic molecules with special structures and functions, and are widely used in medicinal chemistry, materials science and other fields. And hydrazine can be oxidized to form a variety of nitrogen-containing functional groups, which further expands its chemical transformation path.
The existence of the pyridine ring endows the molecule with aromaticity and improves its chemical stability. However, the electronegativity of the nitrogen atom of the pyridine ring also affects the distribution of electron clouds on the ring, making its adjacent and para-sites more prone to electrophilic substitution reactions. This property can be used to introduce other functional groups to enrich the structure and function of compounds.
In addition, the solubility of 5-Bromo-2-hydrazinopyridine is affected by molecular polarity. Since the molecule contains polar groups, it has some solubility in polar solvents such as alcohols and DMF (dimethylformamide), but poor solubility in non-polar solvents. This solubility characteristic is crucial in its separation, purification and choice of reaction medium.
In summary, 5-Bromo-2-hydrazinopyridine exhibits diverse chemical properties due to its functional groups and pyridine ring structure, and has broad application prospects in organic synthesis and related fields.

The price of 5-bromo-2-hydrazinopyridine in the market varies depending on the quality, quantity, and supplier. In the context of "Tiangong Kaiwu", although there is no price statement for this confirmed product, it can be inferred.
Looking at the price of chemical raw materials, if it is of ordinary quality, if purchased in small quantities, the price per gram may be between tens and hundreds of yuan. If the quality is excellent and suitable for high-end scientific research experiments, the price will be high, or over 100 yuan per gram.
If purchased in bulk, the quantity will reach kilograms. Due to economies of scale, the price may be reduced, and the price per gram may be reduced to tens of yuan. If there are many suppliers and the competition is intense, the price will be lower; if there are few suppliers and scarce resources, the price will increase.
In summary, the market price of 5-bromo-2-hydrazine pyridine is high in small quantities and low in batches, often tens of yuan to more than 100 yuan per gram. The actual price should be determined according to specific circumstances.