5-Bromo-2-ethynylpyridine

5-Bromo-2-ethynylpyridine is also an organic compound. Its chemical properties are particularly important and are related to the process of many organic synthesis reactions.
In this compound, the bromine atom and the acetylene group are attached to the pyridine ring. The bromine atom has the activity of nucleophilic substitution reaction. Under appropriate reaction conditions, it can be substituted with nucleophilic reagents. For example, when it encounters nucleophilic reagents such as alkoxides and amines, the bromine atom can be replaced to form new carbon-oxygen and carbon-nitrogen bonds, which are quite useful in the fields of drug synthesis and materials chemistry.
Ethynyl also gives the compound unique reactivity. First, it can perform typical reactions of alkynes, such as coupling reactions catalyzed by transition metals. Using metals such as palladium and copper as catalysts, it can be coupled with halogenated aromatics and olefin halides to form compounds with conjugated structures, which is of great significance for the preparation of optoelectronic materials. Second, ethynyl groups can participate in cyclization reactions to build complex cyclic structures.
Furthermore, the electronic properties of pyridine rings affect the reactivity of the whole molecule. Pyridine rings are alkaline and can form salts with acids, and the electron cloud density distribution on the ring is uneven, which affects the reactivity of substituents. The chemical properties of 5-bromo-2-ethynylpyridine make it an important synthetic building block in organic synthetic chemistry, and play a key role in the creation of novel compounds and functional materials.

5-Bromo-2-ethynylpyridine, a compound that has attracted much attention in organic synthesis, has key uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate. The unique structure of the Geinpyridine ring and the ethynyl group endows the compound with a variety of reactivity. Through clever chemical transformation, various functional groups can be introduced to build complex drug molecules. For example, it can be coupled with other fragments containing specific functional groups through coupling reactions to create new compounds with unique biological activities for the development of new drugs such as antibacterial and anti-cancer.
In materials science, 5-bromo-2-ethynylpyridine also has wonderful uses. It can be used as a cornerstone for building functional materials. Its ethyne group can undergo polymerization to form polymers with special electrical and optical properties. For example, the preparation of polymer materials with photoelectric activity can be used in organic Light Emitting Diode (OLED), solar cells and other fields, providing the possibility for the development of high-performance optoelectronic devices.
Furthermore, in the study of organic synthesis methodologies, it is an important substrate. Chemists can use it to explore novel reaction pathways and mechanisms. Using it as a starting material, by exploring different reaction conditions and catalysts, to develop new methods for organic synthesis with high efficiency and selectivity, it will promote the development of the field of organic chemistry. In conclusion, 5-bromo-2-ethynylpyridine, with its unique structure, has shown broad application prospects in the fields of medicine, materials and organic synthesis, providing strong support for innovation and development in various fields.

5-Bromo-2-ethynylpyridine is also an organic compound. Its synthesis method involves many chemical delicacies, and the steps also need to be rigorous. The common synthesis route involves the introduction of bromine atoms at the 5th position of the pyridine ring first, which can be used as an electrophilic substitution method. 5-bromopyridine can be obtained by reacting pyridine with brominating reagents, such as bromine, in the presence of suitable catalysts, such as iron powder or iron tribromide, at appropriate temperatures and reaction times.
Then, 5-bromopyridine is reacted with an ethynylation reagent to introduce ethynyl groups. This step can often be used for palladium-catalyzed coupling reactions, such as the Sonogashira reaction. Using 5-bromopyridine and ethynyl trimethylsilane as raw materials, under the joint action of palladium catalysts such as tetra (triphenylphosphine) palladium (0) and bases such as potassium carbonate, in a suitable organic solvent such as N, N-dimethylformamide, heat and stir to make the reaction proceed smoothly. After the reaction is completed, after appropriate post-treatment, such as extraction, column chromatography, etc., to purify the product, pure 5-bromo-2-ethynylpyridine can be obtained. In the process of synthesis, attention must be paid to the precise control of the reaction conditions at each step, the purity of the raw materials and reagents, and the cleanliness and sealing of the reaction device, so as to obtain the target product with higher yield and purity.

5-Bromo-2-ethynylpyridine is a commonly used reagent in organic synthesis. When storing and transporting this chemical, there are many key points that need to be paid special attention.
First words storage. Because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. High temperature and humidity can easily cause chemical reactions and cause them to deteriorate. The warehouse temperature should be controlled within a specific range to prevent it from decomposing or causing other adverse reactions due to excessive temperature. In addition, this product needs to be kept away from fire and heat sources, because organic compounds are flammable, in case of open flames, hot topics or risk of explosion.
At the same time, 5-bromo-2-ethynylpyridine should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, contact with these substances is prone to chemical reactions, which in turn endanger storage safety. The storage place should also be equipped with suitable materials to contain leaks, in case of leakage, it can be dealt with in time to reduce hazards.
Second transportation. Be sure to ensure that the packaging is complete and well sealed before transportation. Due to its active chemical properties, if the packaging is damaged, it is very likely to leak, posing a threat to the transportation environment and personnel safety. During transportation, it is also necessary to follow relevant regulations and standards and choose suitable transportation tools. Do not mix with contraband items, and transport vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment.
During transportation, always pay attention to temperature and humidity changes, and take timely control measures. Drivers and escorts must also be familiar with the characteristics of the chemical and emergency treatment methods. In case of emergencies on the way, they can be disposed of quickly and properly to ensure transportation safety.

The market price range of 5-bromo-2-ethynylpyridine is difficult to specify. Due to the fickle market, its price is determined by many factors.
First, the cost of raw materials for preparing this compound has a significant impact on its price. If the raw materials required for preparation are scarce and difficult to obtain, or the raw material prices fluctuate violently due to changes in market supply and demand, the cost of 5-bromo-2-ethynylpyridine will rise and fall, which in turn affects the selling price.
Second, the complexity of the production process is also critical. If the production process is cumbersome, requires high-end equipment and exquisite technology, and the production conditions are strictly controlled, it will greatly increase the production cost and cause the market price to be high.
Third, the amount of market demand also affects its price. If many industries have strong demand for 5-bromo-2-ethynylpyridine, but the supply is relatively insufficient, the price will rise; on the contrary, if the demand is weak and the supply is excessive, the price will inevitably fall.
Fourth, different suppliers have different pricing strategies. Some seek small profits but quick turnover to seize the market at a low price; some set higher prices because of their unique advantages, such as high product purity and excellent service.
Overall, the market price of 5-bromo-2-ethynylpyridine may fluctuate between a few yuan and several hundred yuan per gram. For small scientific research purposes, due to small quantities and high purity requirements, the price may be in a higher range; if it is a large-scale industrial purchase, due to large quantities, the price may be favorable and relatively low. However, this is only a rough guess, and the actual price still depends on specific market conditions and transaction details.