5-Bromo-2-ethoxypyridine

5-Bromo-2-ethoxypyridine is also an organic compound. It has a wide range of uses and plays a significant role in the field of organic synthesis.
One of them can be used as a pharmaceutical intermediate. In the synthesis process of many drugs, 5-bromo-2-ethoxypyridine plays a key role. For example, when developing specific antimalarial drugs, this compound can participate in the construction of the core structure of drug molecules. Due to the properties of bromine atoms and ethoxy groups in its structure, it can be combined with other organic fragments through a series of chemical reactions to gradually build drug molecules with specific pharmacological activities, which can help drug developers create more effective antimalarial drugs.
Second, it is also used in materials science. It can be used to synthesize functional organic materials. With its unique chemical structure, it can be introduced into the structure of polymer materials through specific reactions. In this way, the synthesized polymer materials may have special optical and electrical properties, such as materials with specific luminescent properties, which can be used in the field of organic Light Emitting Diode (OLED) to improve the efficiency of display technology.
Furthermore, in the field of pesticide synthesis, 5-bromo-2-ethoxypyridine is also indispensable. It can be used as an important starting material to synthesize pesticides with high insecticidal and bactericidal properties through multi-step reactions. By rationally designing the reaction path and using its structural characteristics, the final generated pesticide has high selectivity and strong lethality to specific pests and diseases, and has relatively little impact on the environment, which contributes to the sustainable development of agricultural production.
In summary, 5-bromo-2-ethoxypyridine has shown important application value in many fields such as medicine, materials, and pesticides, providing key support for the development of many industries.

There are several common methods for synthesizing 5-bromo-2-ethoxypyridine.
First, 2-hydroxypyridine is used as the starting material. First, 2-hydroxypyridine is combined with a brominating reagent, such as bromine or N-bromosuccinimide (NBS), under suitable reaction conditions. Usually, in an organic solvent such as dichloromethane, an appropriate amount of catalyst, such as iron powder or iron tribromide, is added, and the reaction is initiated by heating or lighting. The fifth position of the pyridine ring can be introduced into the bromine atom to generate 5-bromo-2-hydroxypyridine. Then, 5-bromo-2-hydroxypyridine is reacted with ethanol under basic conditions, such as potassium carbonate, sodium hydroxide, etc. The reactants are mixed in suitable solvents such as N, N-dimethylformamide (DMF) or acetonitrile, heated and refluxed, and the hydroxyl groups undergo nucleophilic substitution reaction with ethanol to obtain 5-bromo-2-ethoxypyridine.
Second, 2-chloropyridine is used as the starting material. First, 2-chloropyridine is brominated with a brominating agent to obtain 5-bromo-2-chloropyridine. Subsequently, 5-bromo-2-chloropyridine is reacted with sodium ethanol in ethanol solution. The ethoxy negative ion in sodium ethanol acts as a nucleophilic reagent to attack the carbon atoms connected to chlorine on the pyridine ring, and a nucleophilic substitution reaction occurs. The chlorine atom is replaced by ethoxy. After this step, the target product 5-bromo-2-ethoxy pyridine can be obtained.
Third, pyridine can also be used as a raw material. First, pyridine is ethoxylated. Pyridine can be reacted with ethanol under specific catalysts and reaction conditions to introduce ethoxy groups into the second position of the pyridine ring to generate 2-ethoxy pyridine. After that, 2-ethoxy pyridine was brominated with a brominating reagent, and bromine atoms were introduced at the 5th position to obtain 5-bromo-2-ethoxy pyridine. This synthetic route requires attention to control the reaction conditions to ensure the reaction selectivity and yield.

The market price of 5-bromo-2-ethoxypyridine often varies with many factors, and it is difficult to directly state the exact price.
First, the purity of this compound has a great impact on the price. If the purity is extremely high, it is close to the experimental or pharmaceutical grade standard, that is, there are very few impurities, and the price is often high. To obtain such a high purity product, the purification process required is complicated and expensive, such as multiple distillations, recrystallization, or the use of high-end chromatographic separation technology, which drives up the cost and causes the price to rise.
Second, the market supply and demand relationship also affects its price. If there is a large increase in demand for 5-bromo-2-ethoxypyridine in a certain field at a certain time, such as the development of specific new drugs in the pharmaceutical industry, it needs to be used as a key intermediate, and the supply is relatively insufficient, the price will rise. On the contrary, if the demand is low, the manufacturer's inventory is overstocked, and the price may be reduced for promotional sales.
Third, the production scale and cost are also important factors. In large-scale production, due to the scale effect, the unit production cost may be reduced. For example, the purchase of raw materials is discounted due to large quantities, and the utilization rate of equipment is improved. The price may be relatively close to the people. However, in small-scale production, the unit cost is high, and the price will be higher.
According to the past market, the price of 5-bromo-2-ethoxypyridine with low purity (about 90%) may be in the tens of yuan per gram. For high purity (more than 98%), the price per gram may exceed 100 yuan, or even higher, up to hundreds of yuan per gram, depending on the actual market situation at that time.

5-Bromo-2-ethoxypyridine, which is also a key intermediate in organic synthesis, is widely used in the fields of medicine and pesticides. To understand its physical and chemical properties, let me tell you one by one.
First talk about its physical properties. At room temperature, 5-bromo-2-ethoxypyridine is often a colorless to light yellow liquid, which is clear and transparent, just like autumn water. Its boiling point is about 210-212 ° C. At this temperature, the liquid will turn into curling steam. The melting point is around -10 ° C. When the temperature drops, the liquid that originally flowed will solidify into a solid state, just like water turns into ice when it meets cold. Its density is about 1.38 g/cm ³, which is heavier than water. If it is co-located with water, it will sink to the bottom of the water.
Let's talk about the chemical properties again. Among the 5-bromo-2-ethoxy pyridine, the bromine atom has good activity and is easy to participate in nucleophilic substitution reactions. Because the bromine atom is highly electronegative, the carbon-bromine bond electron cloud is biased towards the bromine atom, causing the carbon atom to be partially positively charged and vulnerable to attack by nucleophilic reagents. For example, when reacted with sodium alcohol, corresponding ether compounds can be formed. The presence of ethoxy groups also affects the distribution of the electron cloud in the pyridine ring, making the specific position on the pyridine ring more prone to substitution reactions. Its pyridine ring has a certain alkalinity, because there are lone pairs of electrons on the nitrogen atom, which can accept protons and form salts when exposed to acids.
In short, 5-bromo-2-ethoxy pyridine has unique physical and chemical properties and plays an indispensable role in the stage of organic synthesis, providing an important foundation for the preparation of many compounds.

5-Bromo-2-ethoxypyridine is a chemical commonly used in organic synthesis. When storing and transporting, many things need to be paid attention to.
When storing, the first environment. Must choose a cool, dry and well-ventilated place. This is easy to cause it to deteriorate due to its nature or fear of heat, moisture, high temperature and humidity. If it is heated or triggers a chemical reaction, it will damage its quality; if it is exposed to moisture or hydrolysis, it will lose its original characteristics.
Furthermore, storage containers are also critical. A sealed container should be used to prevent it from coming into contact with air. 5-Bromo-2-ethoxypyridine may react with oxygen, water vapor, etc. in the air. Containers made of glass or specific plastics are preferred, because their chemical properties are stable and do not react with the chemical.
When transporting, safety is the most important thing. It must be properly packaged according to the specifications of chemical transportation. The name, characteristics and precautions of the product should be clearly marked on the outside of the package so that the transporter can know. And during transportation, make sure that the temperature and humidity are stable, avoid bumps and vibrations, and prevent package damage.
In addition, 5-bromo-2-ethoxypyridine may have certain toxicity and irritation. Those who store and transport it should be prepared for protective measures. Such as wearing protective clothing, gloves and goggles, etc., to avoid contact with the skin, eyes, if inadvertent contact, should be promptly treated according to emergency treatment.