5-Bromo-2-cyano-3-(trifluoromethyl)pyridine

5-Bromo-2-cyano-3- (trifluoromethyl) pyridine is an important compound in organic chemistry. Its physical properties are quite unique, let me tell them one by one.
When it comes to appearance, this compound is often in the form of white to off-white crystalline powder. This morphology is easy to observe and process, and in many chemical operations, this appearance characteristic is helpful for preliminary identification and judgment.
Its melting point is also one of the key physical properties. However, the exact melting point varies slightly due to preparation methods, purity and other factors, and is roughly within a certain temperature range. The determination of melting point is of great significance in identifying the purity of the compound and performing related reactions. 5-Bromo-2-cyano-3- (trifluoromethyl) pyridine with high purity has a relatively fixed melting point. If the purity is not good, the melting point may be offset.
In terms of solubility, this compound exhibits a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, it can be moderately dissolved to form a uniform solution. This property makes it possible to use dichloromethane as a solvent in organic synthesis reactions to carry out various reactions smoothly. The solubility is better in DMF, which is attributed to the strong polarity of DMF and the strong interaction between the molecules of the compound, which promotes its dissolution.
In addition, the density of the compound is also a characterization of its physical properties. Although the exact density value varies depending on the measurement conditions, it is roughly within a certain range. Knowledge of density is indispensable in accurately weighing and calculating the proportion of reactants, and is related to the success or failure of the reaction and the quality of the product.
The physical properties of 5-bromo-2-cyano-3- (trifluoromethyl) pyridine are key considerations in organic synthesis, pharmaceutical chemistry and other fields, which have a profound impact on its application and research.

5-Bromo-2-cyano-3- (trifluoromethyl) pyridine is also an important intermediate in organic synthesis. In the field of medicinal chemistry, it has a wide range of uses. First, it can be used to create new antibacterial drugs. With its unique chemical structure, it can combine with specific targets in bacteria, interfere with the metabolism and reproduction of bacteria, and achieve antibacterial effect. Second, it also plays an important role in the research and development of anti-cancer drugs. By precisely modifying its structure, drugs can be more easily targeted to cancer cells, inhibit the growth and spread of cancer cells, and provide new ways to overcome cancer problems.
Furthermore, in the field of pesticide chemistry, this compound can be used as a synthetic raw material for high-efficiency insecticides. Due to its special biological activity against pests, it can quickly penetrate the body surface of pests, interfere with their nervous system or physiological metabolism, paralyze or kill pests, and is relatively friendly to the environment. The residue is low, which is in line with the development trend of green pesticides today.
In addition, in the field of materials science, 5-bromo-2-cyano-3- (trifluoromethyl) pyridine can be prepared with special optical and electrical properties through specific reactions. Functional materials can be used in the manufacture of organic Light Emitting Diodes (OLEDs), solar cells, etc., which contribute to the development of new energy and optoelectronics industries. Overall, this compound has shown great application potential in many fields, promoting the progress and development of related industries.

5-Bromo-2-cyano-3- (trifluoromethyl) pyridine is also an important intermediate in organic synthesis. There are various synthesis methods, each has its own advantages and disadvantages, and is described as follows:
First, the compound containing the pyridine ring is used as the starting material, and it is prepared by a series of reactions such as halogenation, cyanylation, and trifluoromethylation. For example, an appropriate pyridine derivative can be taken first, and a brominating reagent can be used for halogenation to connect the bromine atom to a specific location. Commonly used brominating reagents include liquid bromine, N-bromosuccinimide (NBS), etc. When a bromine-containing pyridine intermediate is obtained, a cyano group is introduced. Cyanylation can be achieved by reacting with cyanide reagents such as potassium cyanide (KCN) or cuprous cyanide (CuCN) under suitable reaction conditions. Finally, trifluoromethylation reagents such as trifluoromethyl halide or trifluoromethylation reagents are combined to complete the introduction of trifluoromethyl to obtain the target product 5-bromo-2-cyano-3- (trifluoromethyl) pyridine. The steps of this method are relatively clear, but the reaction conditions of each step need to be precisely controlled to improve the yield and selectivity.
Second, to construct a strategic synthesis of pyridine rings. The target product is obtained directly by cyclization of bromine, cyano and trifluoromethyl-related fragments under specific catalyst and reaction conditions. This method has the advantages of simple steps, which can reduce the cumbersome process of intermediate product separation and improve atomic economy. However, the conditions of multi-component reaction are relatively complex, and the reaction substrate ratio, catalyst type and dosage, reaction temperature and time need to be carefully optimized to achieve the desired reaction effect.
Third, the synthesis path based on metal catalysis. Coupling reactions catalyzed by transition metal catalysts such as palladium (Pd) and copper (Cu). Organometallic reagents containing bromine, cyano or trifluoromethyl can be prepared first, and then coupled with other suitable substrates under the action of metal catalysts to gradually build the target molecular structure. Metal catalysis reactions are usually characterized by high efficiency and good selectivity, but metal catalysts are expensive, and post-reaction treatment requires consideration of metal residues, which also requires high reaction equipment and process requirements.

5-Bromo-2-cyano-3- (trifluoromethyl) pyridine is an important compound commonly used in organic synthesis. When storing this compound, many matters must be paid attention to.
Choice of the first environment. When placed in a cool and dry place, do not expose it to direct sunlight. The energy of sunlight may cause it to undergo photochemical reactions, causing structural changes and quality damage. In addition, temperature is also critical. High temperature can easily promote changes in its reactivity, so it is generally appropriate to be stored at room temperature or slightly lower temperature. It can usually be stored in a refrigerated environment of 2-8 ° C. If long-term storage is required, freezing conditions may be more suitable.
Furthermore, the choice of container should not be ignored. It must be made of corrosion-resistant materials, such as glass or specific plastic materials. Because of its certain chemical activity, ordinary materials or reactions with them affect its purity and stability. And the container must be well sealed to prevent moisture and air from invading. Moisture or hydrolysis reactions occur, and oxygen in the air may also cause adverse reactions such as oxidation.
In addition, the storage place should be away from fire sources, heat sources and strong oxidizing agents. This compound may be flammable, and it will be dangerous in case of fire and heat sources. Strong oxidizing agents are also prone to react violently with it, causing safety accidents.
Again, the label must be clearly marked. On the container, specify the name, purity, storage conditions, production date and other information of the compound. In this way, when it is used, it is clear at a glance, and it is easy to trace back to ensure its safety and quality control.
All in all, proper storage of 5-bromo-2-cyano-3- (trifluoromethyl) pyridine is closely related to its quality and use efficiency, and is closely related to the safety of experimentation and production. All precautions should be taken with caution.

5-Bromo-2-cyano-3- (trifluoromethyl) pyridine, the price of this product in the market is difficult to determine. Due to the changeable market conditions, the state of supply and demand, the novelty of the process, and the price of raw materials can all make their prices vary.
Looking at the city of the past, its price often moves with the times. When raw materials are abundant and the process is advanced, the price may decline; if raw materials are scarce and demand surges, the price will often rise. And in different places, the price varies depending on transportation and taxes.
However, if you want to know the exact price, you can ask the chemical raw material suppliers, who often move due to the market and can tell the real-time price. Or refer to the chemical trading platform and look at its past transaction price, you can also know the approximate price. Although it is difficult to determine the exact number, following this method, you can get the price range for commercial reference.