5-bromo-2-chloropyridine-3-carbonitrile

5-Bromo-2-chloropyridine-3-formonitrile is one of the organic compounds. In its molecular structure, the 3rd position of the pyridine ring has a methonitrile group, the 2nd position is a chlorine atom, and the 5th position is a bromine atom.
In terms of its chemical properties, the methonitrile group has a certain activity. It can participate in a variety of reactions, such as under suitable conditions, the methonitrile group can be hydrolyzed to a carboxyl group, or nucleophilic addition reactions occur with nucleophilic reagents. Due to the high electron cloud density of carbon-nitrogen triple bonds in the nitrile group, it is vulnerable to attack by nucleophilic reagents.
The chlorine atom and the bromine atom Both are halogen atoms, which can undergo nucleophilic substitution reactions. In view of the slightly higher activity of bromine atoms than chlorine atoms, bromine atoms are more susceptible to substitution under appropriate reagents and conditions, depending on the reaction conditions and the reagents involved. The
pyridine ring itself is aromatic, and its π electron number conforms to the condition of 4n + 2 (n is an integer) because it satisfies the Shocker rule. This aromaticity imparts a certain stability to the compound, and at the same time affects its reactivity and selectivity. 5-Bromo-2-chloropyridine-3-formonitrile is very important in the field of organic synthesis. It is often used as a key intermediate to prepare various bioactive compounds, such as drugs and pesticides. Due to the introduction of different substituents, its biological activity and physicochemical properties can be significantly changed.

There are several common methods for the synthesis of 5-bromo-2-chloropyridine-3-formonitrile.
First, the pyridine derivative is used as the starting material. First, the appropriate pyridine compound is taken and brominated under specific reaction conditions. Suitable brominating reagents can be selected, such as liquid bromine, N-bromosuccinimide (NBS), etc. In appropriate solvents, such as dichloromethane, carbon tetrachloride, etc., by adjusting the reaction temperature, time and other parameters, the bromination reaction occurs at a specific position on the pyridine ring to obtain bromine-containing pyridine intermediates. Subsequently, the intermediate is chlorinated, and suitable chlorination reagents, such as phosphorus oxychloride and phosphorus pentachloride, are selected. In a suitable reaction environment, the pyridine ring is further chlorinated, thereby introducing chlorine atoms. Finally, through cyanation reaction, cyanide reagents, such as potassium cyanide and sodium cyanide, are used to introduce cyanyl groups at specific positions on the pyridine ring, resulting in 5-bromo-2-chloropyridine-3-formonitrile.
Second, halogenated pyridine nitrile can also be used as a raw material. First obtain pyridine nitrile containing specific halogen atoms, and then select suitable halogenated reagents and reaction conditions according to needs, and selectively introduce another halogen atom on the pyridine ring. For example, if the starting material is chlorine-containing pyridinonitrile, bromine atoms can be introduced by suitable bromination means to synthesize the target product.
Third, pyridine-3-formonitrile can also be considered as the starting material. First, pyridine-3-formonitrile is brominated, and a suitable brominating agent is selected to control the reaction conditions to bromide the pyridine ring at a specific position. Then chlorination is carried out, chlorine atoms are introduced, and a series of reaction conditions are finely regulated to achieve the synthesis of 5-bromo-2-chloropyridine-3-formonitrile. In the synthesis process, attention should be paid to the precise control of reaction conditions, including temperature, pH, reaction time, etc., and the effective separation and purification of the reaction products at each step should be carried out to ensure the purity and yield of the target product.

5-Bromo-2-chloropyridine-3-formonitrile is an important intermediate in organic synthesis. It has a wide range of uses and is often a key starting material for the creation of new drugs in the field of medicinal chemistry. Due to its unique molecular structure, it can introduce various functional groups through a variety of organic reactions to construct compounds with specific biological activities. For example, it can be substituted with nucleophiles. After careful design and operation, a series of pyridine derivatives with potential pharmacological activity can be prepared, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs.
also plays a pivotal role in the field of pesticide chemistry. By chemically modifying and derivatizing it, new pesticides with high efficiency, low toxicity and environmental friendliness can be created. For example, by adding phosphorus and sulfur-containing functional groups through specific reactions, the products may be endowed with excellent insecticidal, weeding and bactericidal properties, which can help the sustainable development of agriculture.
In addition, in the field of materials science, 5-bromo-2-chloropyridine-3-formonitrile is also used. After specific polymerization reactions or chemical modifications, it can be introduced into the structure of polymer materials, thereby imparting special electrical, optical or thermal properties to the materials, providing the possibility for the development of new functional materials. In conclusion, due to its structural properties and reactivity, 5-bromo-2-chloropyridine-3-formonitrile is an indispensable and important substance in many fields of organic synthesis.

5-Bromo-2-chloropyridine-3-formonitrile is also an organic chemical. During storage and transportation, many matters need to be paid careful attention.
First words storage, this compound should be placed in a cool and dry place. Because of its active chemical properties, it may cause reactions, deterioration or damage to quality when heated or wet. Therefore, it is essential to choose a storage environment with low temperature and low humidity. And should be separated from oxidizing agents, acids, bases and other chemicals. This is because 5-bromo-2-chloropyridine-3-formonitrile is prone to chemical reactions with them, or causes fire or explosion.
Furthermore, the storage must be well ventilated to avoid the accumulation of harmful gases. And set up obvious warning signs to make warehousers aware of its danger. And should be regularly inspected to check whether the packaging is damaged or leaking. If so, it must be dealt with in time to prevent pollution of the environment and endanger the safety of personnel.
As for transportation, there are also many points. Before transportation, make sure that the packaging is in good condition and there is no risk of leakage. Choose appropriate means of transportation and follow relevant transportation regulations according to their dangerous characteristics. During transportation, it is necessary to prevent sun exposure, rain and high temperature. If it is a long-distance transportation, the condition of the goods should be checked regularly. The escort personnel must be familiar with its nature and emergency treatment methods. In case of emergencies, they can respond quickly and reduce the damage.
In short, the storage and transportation of 5-bromo-2-chloropyridine-3-formonitrile must strictly abide by safety regulations, and must not be slack a little, so as to ensure the safety of personnel and the environment.

5-Bromo-2-chloropyridine-3-formonitrile, the price of this product in the market is difficult to determine. The change in its price depends on multiple ends.
First, the situation of supply and demand affects its price. If there are many applicants, but there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline.
Second, the cost of the system is also a major factor. The price of raw materials, the consumption of labor costs, and the cost of equipment will all depend on the cost. If the price of raw materials is high, or the cost of labor increases greatly due to the difficulty of craftsmanship, the price of its products will also be high.
Furthermore, the competition in the market is related to the level of price. Competing in the same industry, or cutting prices for the sake of competing for the market; if there is no strong competition, the price may be stable and high.
There are also policies and regulations. Environmental regulations and taxes can change costs and prices.
According to past market conditions, the price of this product per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximate number, and the market conditions are ever-changing, and it is difficult to have a definite value. For real-time prices, you can consult the merchants of chemical raw materials, the platforms for entering the market, or refer to industry reports to get a near-real price.