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What are the physical properties of 5-bromo-2-chloro-4-hydroxypyridine?
What are the physical properties of 5 + -mercury-2 + -bromo-4 + -fluorotoluene? Mercury is a liquid metal at room temperature, with a silver-white and metallic luster, a high density, about 13.59 g/cm3, easy to flow, and a low vapor pressure, with a certain volatility. Mercury has poor thermal conductivity, but its electrical conductivity is acceptable.
Bromine is the only non-metallic element in a liquid state at room temperature and pressure. It is dark reddish-brown in color, has a strong pungent odor, and is highly corrosive. Its density is about 3.119 g/cm3, its melting point is -7.2 ° C, and its boiling point is 58.8 ° C. It is volatile and forms a reddish-brown bromine vapor.
As for 4-fluorotoluene, it is a colorless and transparent liquid at room temperature, with an aromatic odor. Its density is about 0.985 g/cm3, the melting point is -56.5 ° C, and the boiling point is 116-117 ° C. It is insoluble in water and can be miscible with organic solvents such as ethanol and ether.
The physical properties of these three substances are obviously different. Mercury is unique as a liquid metal, bromine is a liquid non-metal and is highly corrosive and volatile. 4-fluorotoluene is distinguished by the characteristics of organic liquids, such as specific density, melting boiling point and solubility. The three have their own uses in different fields. However, due to the toxicity of mercury and bromine, careful protection should be taken when using them to avoid harm.
What are the chemical properties of 5-bromo-2-chloro-4-hydroxypyridine
5 + -Mercury-2 + -bromo-4 + -aminopyridine, each of these substances has its own unique chemical properties.
Mercury is a liquid metal at room temperature, with a silver-white metallic luster. Its chemical properties are relatively stable, and it is not easy to react with oxygen. However, under heating conditions, it can combine with oxygen to form mercury oxide. Mercury can dissolve many metals to form amalgam, which is widely used in metallurgy and other fields. However, mercury is highly toxic and volatile, and its vapor inhaled into the human body can cause serious damage to the nervous system, kidneys, etc.
Bromine is a non-metallic element that is liquid at room temperature. It is a dark reddish-brown smoky liquid with a strong irritating odor. Bromine is highly oxidizing and can react with most metals and some non-metals. For example, when it encounters sodium metal, it can react violently to form sodium bromide. In organic synthesis, bromine is often used as an important reagent for introducing bromine atoms to change the properties of organic compounds.
4-aminopyridine contains an amino group and a pyridine ring structure. The amino group is basic and can react with acids to form salts. The pyridine ring makes the substance have certain aromatic properties and stability. 4-aminopyridine can participate in a variety of organic reactions, such as reacting with acyl chloride to form amide compounds. In the field of medicine, it has potential medicinal value because it has a regulatory effect on some ion channels.
What are the common synthesis methods of 5-bromo-2-chloro-4-hydroxypyridine?
Although the common synthesis methods of 5-hydroxyl-2-naphthalene-4-sulfoaniline are not recorded in Tiangong Kaiwu, the following deductions can be made based on ancient technological ideas and modern chemical knowledge.
First, you can start from naphthalene. Naphthalene is sulfonated under appropriate conditions, such as concentrated sulfuric acid and a certain temperature. Concentrated sulfuric acid, as a sulfonating agent, can introduce sulfonic acid groups into naphthalene at specific positions to obtain products such as naphthalene-1-sulfonic acid or naphthalene-2-sulfonic acid. This step of reaction is similar to the ancient idea of reacting minerals with strong acids for material transformation. Although the ancient strong acid is not as convenient as modern times, the principle is the same.
Next, if naphthalene-2-sulfonic acid is obtained, the nitro group can be introduced into the naphthalene ring at a specific position under the action of a suitable nitrifying agent such as mixed acid (nitric acid mixed with sulfuric acid). This step requires precise control of the reaction conditions. Temperature, reagent ratio, etc. all affect the nitro substitution position. Although there was no precise instrument in ancient times, the reaction can be grasped to a certain extent by experience.
Then, the nitro-containing naphthalene sulfonic acid is reduced, and the nitro group can be reduced to amino group by a system such as iron powder and hydrochloric acid. In this process, iron powder is used as a reducing agent, and hydrochloric acid provides an acidic environment to convert nitro groups into amino groups, similar to the reaction between metals and acid in ancient times.
Then the amino-containing naphthalenesulfonic acid is hydroxylated. Suitable hydroxylating reagents such as some oxidizing agents under basic conditions can be used to introduce hydroxyl groups at specific positions. Although there are no modern accurate hydroxylating reagents in ancient times, similar functional group conversion is also achieved by using natural oxygenates or oxidizing intermediates produced by the reaction of basic substances with other substances.
Finally, pure 5-hydroxyl-2-naphthalene-4-sulfoaniline is obtained through a series of separation and purification steps, such as crystallization, distillation, extraction, etc. Although the ancient method is simple and rough, basic separation methods such as crystallization have been used, and the purity of the product can be improved to a certain extent through repeated operations.
In which fields is 5-bromo-2-chloro-4-hydroxypyridine used?
5 + - - 2 - wallow - 4 - carboxypyridine has applications in the following fields:
In the field of medicine, carboxypyridine can be used as a key intermediate for the synthesis of various drugs. For example, in the preparation of some antibacterial drugs, it can participate in the reaction with its unique chemical structure, promoting the synthesis of substances with high antibacterial activity. At the same time, in the field of anti-tumor drug research and development, it is possible to obtain new drugs with specific inhibitory effects on tumor cells.
In the field of materials science, 5 - - 2 - wallow - 4 - carboxypyridine can be used to prepare functional polymer materials. By polymerizing with other monomers, polymer materials can be endowed with special optical and electrical properties. For example, in optoelectronic materials, the prepared materials may have excellent fluorescence properties and can be applied to optoelectronic devices such as Light Emitting Diode.
In the field of organic synthesis, it is an important building block for organic synthesis and can participate in the construction of many complex organic compounds. With the reactivity of its specific functional groups, the precise construction of carbon-carbon bonds and carbon-heteroatomic bonds can be realized, providing an effective way for the synthesis of organic molecules with specific structures and functions, and assisting in the synthesis of a series of natural product analogs or new organic compounds with unique structures and properties.
In the field of catalysis, 5-@-@2-wallow-4-carboxypyridine and its derivatives may be used as ligands to coordinate with metal ions to form efficient catalysts. This catalyst exhibits excellent catalytic activity and selectivity in some organic reactions, such as hydrogenation reactions, oxidation reactions, etc., which can significantly improve the reaction efficiency and product selectivity, thus having potential application value in chemical production and other aspects.
What is the market price of 5-bromo-2-chloro-4-hydroxypyridine?
In the market, the change of prices is related to the feelings of the public. If you want to discuss the market price of 5 + -mercury-2-bromo-4-fluoropyridine, you should consider various factors in detail.
The market price of this product depends first on the state of supply and demand. If there are many people in the world who need to use 5 + -mercury-2-bromo-4-fluoropyridine, and the amount produced is small, the price will be high. There are many people who ask for it, but there are few who supply it. Rare is precious. On the contrary, if the product is abundant and the user is few, the price will decrease.
Furthermore, the difficulty of refining is also the main reason. If the method of preparing 5 + -mercury-2-bromo-4-fluoropyridine is cumbersome, requires rare materials, is labor-intensive, and there are many difficulties and obstacles in the process, the price will be high. If the method of refining is simple, the materials used are easy to obtain, and the manpower and material resources expended are not much, the price may be low.
And the competition in the market also affects its price. If there are many players competing with each other, in order to sell their goods, or there is a price reduction to win, the price will drop accordingly. If there are few players, the price may be self-specializing.
There are still decrees and regulations. If there is a strict order on the production and sale of this product, or heavy taxes are imposed, or various restrictions are imposed, the cost will increase and the price will also rise. If the decree is lenient and helps its industry, the price may be stable.
As for the market price of 5 + -mercury-2-bromo-4-fluoro-pyridine, it is difficult to determine it. It is necessary to consider the above things comprehensively before we can get a rough estimate. Or when the situation changes, its price will also change accordingly, which cannot be ignored.
