5-Bromo-2-benzyloxy-6-methylpyridine

The physical properties of 5-hydroxy- 2-amino-6-methylpyridine are as follows:
This substance is mostly a crystalline solid under normal conditions. Looking at its color, it is often white to off-white, and the texture is relatively fine. Its melting point is quite critical, about a specific temperature range. This melting point characteristic is quite important in the identification and purification. The purity and authenticity can be determined by the method of melting point.
When it comes to solubility, 5-hydroxy- 2-amino-6-methylpyridine has a certain solubility in water, but it is not very soluble. It has better solubility in polar organic solvents such as methanol and ethanol. The difference in solubility is due to the fact that its molecular structure contains both hydrophilic hydroxyl and amino groups, as well as hydrophobic methyl and pyridine rings. Because its structure contains many polar groups, it can form hydrogen bonds with polar solvent molecules, so it has better solubility in polar solvents.
Furthermore, 5-hydroxy- 2-amino-6-methylpyridine has certain stability, but its structure may change in the environment of strong acid and strong base. Gein amino and hydroxyl groups are easy to react with acid and base. And under specific conditions such as high temperature and light, it may also cause chemical changes, or cause decomposition, polymerization and other reactions.
In addition, the substance has a certain degree of hygroscopicity. Because the hydroxyl and amino groups in the molecule easily form hydrogen bonds with water molecules in the air, it is easy to absorb moisture in the air. Therefore, when storing, it is necessary to pay attention to the humidity of the environment. It should be stored in a dry place to prevent moisture decomposition and affect its quality and performance.

To prepare 5-hydroxyl-2-amino-6-methylpyridine, the following ancient method can be used.
First take the appropriate starting material, such as a compound containing a pyridine ring as the base, the compound needs to have a modifiable functional group, which is the basis for subsequent reactions. Optional pyridine derivatives with halogen atom substitution, such as halopyridine, can provide an active check point for the reaction, so that they can be introduced into the desired group by nucleophilic substitution reaction.
Introduce amino groups by nucleophilic substitution reaction. Take halogenated pyridine and place it in a suitable reaction solvent, such as a polar aprotic solvent, such as dimethylformamide (DMF), which can promote the reaction. Add an amino-containing reagent, such as ammonia or amine compounds, and react at an appropriate temperature and pressure. The temperature may need to be controlled in a moderate range, such as 50-100 ° C. The pressure can be adjusted according to the specific reaction, so that the halogen atom is replaced by an amino group to obtain an amino-containing pyridine intermediate.
Then a hydroxyl group is introduced. The resulting intermediate can be achieved by a suitable hydroxylation reaction. For example, reactions involving metal-organic reagents can be achieved. The intermediate is treated with organolithium reagent or Grignard reagent to form a carbon anion active species first, and then reacted with a reagent containing hydroxyl groups, such as water or alcohol derivatives, the hydroxyl groups are introduced to the designated position of the pyridine ring to obtain a pyridine product containing amino groups and hydroxyl groups.
Finally, methyl groups are introduced. This step can be achieved by alkylation reaction. Select a suitable methylation reagent, such as iodomethane or dimethyl sulfate, and react under alkaline conditions. The alkali can be selected from potassium carbonate, sodium carbonate, etc., in an organic solvent, such as acetonitrile. At an appropriate temperature, such as room temperature to about 50 ° C, the methyl group can be successfully connected to the pyridine ring for a period of time, and the final 5-hydroxy- 2-amino-6-methylpyridine can be obtained.
The whole synthesis process needs to pay attention to the control of the conditions of each step of the reaction, including temperature, pressure, reactant ratio and reaction time, and each step of the product needs to be properly separated and purified to ensure the purity and yield of the final product.

5-Hydroxy-2-amino-6-methylpurine, or caffeine, has the following main uses:
Caffeine is quite common in tea and coffee, and can stimulate the central nervous system. After drinking caffeinated beverages, people can refresh the mind, dispel drowsiness and fatigue, and improve attention and alertness. In ancient times, although there was no scientific understanding like today, when people came into contact with caffeine-containing plants in their daily diet, they could also feel refreshed, their thinking was more agile, they had more energy when working and studying, and could maintain a good state for a longer time.
In the field of medicine, caffeine is also used. It can assist in the treatment of some diseases caused by central nervous system depression, stimulate the respiratory center, and make breathing smoother and more powerful. It can also be combined with other drugs to enhance the efficacy of drugs. In ancient times, although doctors did not fully understand its pharmacology, they noticed in practice that some herbs containing this ingredient had a relieving effect on specific diseases, or used to regulate human body functions and restore health.
In addition, caffeine can be used as an additive in the food industry. It adds unique flavor to food, enhances taste, and makes food more attractive. Although the ancients did not use it as a food additive in the modern sense, some naturally caffeinated ingredients have already played a role in enriching the flavor of the diet in the process of cooking and making drinks, adding a different taste to life.

Today there are 5-hydroxy- 2-furanal-6-methylpyridine, want to know the price of its market. This is a chemical in the field of fine chemicals, and its price often varies depending on quality, purity, and supply and demand.
If it is ordinary purity, it is suitable for general experimental investigators, and the price per gram is about tens of dollars. Because the synthesis method is not complicated, and the raw materials are not scarce and rare, the price is not high.
However, if the purity is extremely high, reaching pharmaceutical grade or electronic grade, suitable for pharmaceuticals, high-end electronic materials and other fields, the price is much higher than that of ordinary ones. The price per gram may be hundreds of dollars, or even more. Due to the purification and refining of high-purity products, exquisite craftsmanship and strict conditions are required, the cost has increased greatly, and the price has also risen.
Furthermore, the market supply and demand situation also has a significant impact on its price. If there are many people who want it, and the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may be downward.
Different suppliers, due to their cost control and operation strategies, will also have different prices. To get an accurate price, you can consult chemical raw material suppliers and chemical product trading platforms, scrutinize the quotations of various channels, and comprehensively compare them to know their approximate market prices.

5-Hydroxy-2-amino-6-methylpyridine, this is a special chemical substance, and there are many key considerations that need to be treated with caution when storing and transporting.
First, when storing, it should be placed in a cool, dry and well-ventilated place. This substance is quite sensitive to humidity and temperature, and humid or high temperature environments can easily cause chemical reactions to occur, which in turn affects the quality. For example, if stored in a humid place, it may cause deliquescence, causing its purity to decrease. Be sure to keep away from fires and heat sources, because the substance may be flammable to a certain extent, and there is a risk of combustion and explosion in case of open flames and hot topics. < Br >
Second, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its active chemical properties, contact with the above substances can easily trigger violent chemical reactions or cause dangerous situations. For example, when it encounters a strong oxidant, it may cause a violent oxidation reaction, release a lot of heat, or even explode.
Third, storage containers also need to be carefully selected. A well-sealed container should be used to prevent it from evaporating or reacting with air components. And the container material must be compatible with the substance and will not chemically react with it. For example, some metal containers may react with the substance, corrode the container and contaminate the substance.
As for transportation, transportation vehicles must be clean, dry, and well protected. To prevent rain and sun exposure, pay close attention to temperature and humidity changes during the journey. Be sure to handle the loading and unloading process with care to avoid damage to the container. If the packaging is damaged, the substance may leak, which may cause harm to the environment and personnel. At the same time, transportation personnel also need professional training, familiar with the characteristics of the substance and emergency treatment methods, in the event of an accident, they can respond quickly and properly to ensure the safety of transportation.