5-bromo-2-(4-bromophenyl)pyridine

5-Bromo-2- (4-bromophenyl) pyridine, which has a wide range of uses and is often a key raw material in the synthesis of medicine. It plays an important role in the creation of specific anti-tumor drugs. Due to the unique structure of the pyridine derivative, it can precisely act on specific targets of tumor cells, interfere with the proliferation and survival pathways of tumor cells, and assist in the development of new drugs.
In the field of materials science, it also has outstanding performance. Because it contains bromine atoms and pyridine rings, it can participate in the preparation of materials with special photoelectric properties. For example, in the preparation of organic Light Emitting Diode (OLED) materials, the addition of this substance can improve the electron transport performance and luminous efficiency of the material, so that the OLED display effect is better, such as brighter colors and higher contrast.
In the field of organic synthetic chemistry, it is an important intermediate that can undergo a variety of chemical reactions to construct complex organic molecular structures. By coupling reactions with different reagents, a series of organic compounds with special functions and structures can be synthesized, providing diverse possibilities for the development of organic synthetic chemistry, promoting the field to continue to advance, giving rise to more novel compounds to meet the needs of different fields.

The synthesis methods of 5-bromo-2- (4-bromophenyl) pyridine are many.
First, it can be prepared from 2- (4-bromophenyl) pyridine by bromination reaction. First dissolve 2- (4-bromophenyl) pyridine in a suitable solvent, such as dichloromethane or carbon tetrachloride. Add an appropriate amount of brominating reagent, such as N-bromosuccinimide (NBS), to the reaction system, and add a small amount of initiator, such as benzoyl peroxide. At a suitable temperature, it is usually heated and refluxed to make the reaction proceed smoothly. During the reaction process, close attention should be paid to the reaction progress, which can be monitored by thin layer chromatography (TLC). After the reaction is completed, the target product can be obtained after post-treatment, such as extraction, washing, drying and column chromatography.
Second, 2-chloropyridine and 4-bromophenylboronic acid are used as raw materials, and carbon-carbon bonds are constructed by Suzuki coupling reaction, and then brominated. First, 2-chloropyridine and 4-bromophenylboronic acid are heated under basic conditions in an organic solvent, such as toluene and ethanol mixed solvent, and a palladium catalyst, such as tetra (triphenylphosphine) palladium (0), is added to the reaction. After the coupling reaction is completed, 2- (4-bromophenyl) pyridine is separated and purified, and then 5-bromo-2- (4-bromophenyl) pyridine can be prepared by the above bromination steps.
Third, bromine atoms and phenyl groups can be gradually introduced from pyridine derivatives through multi-step reactions. First, the specific position of the pyridine is functionalized, such as the introduction of suitable substituents, to facilitate subsequent reactions. After that, bromine atoms are introduced through halogenation reaction, and then 4-bromophenyl is introduced through nucleophilic substitution or other carbon-carbon bond formation reactions. After a series of reactions and separation and purification, the final product is obtained. Each method has its own advantages and disadvantages, and the appropriate synthesis path should be selected according to the actual situation, such as the availability of raw materials, the ease of control of reaction conditions and cost.

5-Bromo-2- (4-bromophenyl) pyridine is a kind of organic compound. Looking at its physical properties, it is often in a solid state at room temperature, due to intermolecular forces. Its melting point is related to the arrangement and interaction of molecular lattices, but the exact value needs to be accurately determined by experiments.
When it comes to solubility, in common organic solvents, such as dichloromethane and chloroform, because its molecular structure contains aromatic rings and bromine atoms, it has a certain lipophilicity, so it has a certain solubility and can be dissolved by interactions such as van der Waals forces between organic solvent molecules. However, in water, due to its overall structure hydrophobic, the polarity is quite different from that of water, and the solubility is very small according to the principle of similar compatibility.
When it comes to appearance, pure or white to light yellow crystalline powder, which is related to the absorption and reflection characteristics of molecular structure to light. Its density is also determined by molecular composition and stacking mode, but the specific data also depend on experimental measurements.
The physical properties of this compound are of great significance in organic synthesis, pharmaceutical chemistry and other fields. In organic synthesis, properties such as solubility and melting point are related to the selection of reaction solvents, the setting of reaction conditions, and the reaction process and product purity. In pharmaceutical chemistry, physical properties are closely related to pharmacokinetic properties such as drug absorption, distribution, and metabolism, which are crucial for the development of new drugs.

I don't know what the price range of 5-bromo-2- (4-bromophenyl) pyridine is in the market. The price of these chemical substances often varies due to many reasons. First, the difficulty of preparation. If the preparation method is cumbersome, requires precious raw materials and complicated steps, the price will be high. Second, the purity of the level. High purity, used in fine experiments, high-end production, the price is also high; low purity, limited use, price or low. Third, the market supply and demand situation. If there are many people who want it, the supply will be few, and the price will rise; on the contrary, if the supply exceeds the demand, the price will drop. There are different suppliers, and different merchants have different pricing due to different costs and strategies. And the market conditions vary from place to place, or the prices vary due to regions, transportation, etc. Therefore, to know the exact price range, it is necessary to check the chemical market in detail and consult suppliers to obtain a more accurate number.

5-Bromo-2- (4-bromophenyl) pyridine, this compound is widely used in many fields such as medicinal chemistry, materials science, organic synthesis, etc.
In the field of medicinal chemistry, due to its unique chemical structure, it can be used as a key intermediate to create new drugs. The structure of the pyridine ring and bromophenyl gives it specific biological activity and binding properties, which is helpful for the development of anti-cancer, antibacterial and neurological diseases. For example, by modifying the structure of this compound, its affinity with specific biological targets can be enhanced, and the efficacy and selectivity of drugs can be improved.
In the field of materials science, 5-bromo-2- (4-bromophenyl) pyridine shows important value. Because of its good optoelectronic properties, it can be used to prepare optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells. In OLEDs, it can be used as a luminescent material or auxiliary material to improve the luminous efficiency and stability of the device; in organic solar cells, it can optimize the charge transfer and conversion efficiency, and promote the performance of solar cells.
In the field of organic synthesis, 5-bromo-2- (4-bromophenyl) pyridine is an extremely useful synthetic block. Its bromine atom has high activity, and it can be connected with other organic molecules through a variety of organic reactions, such as Suzuki coupling reaction and Stille coupling reaction, to build complex and diverse organic compounds. With this, chemists can synthesize organic materials with unique functions and structures, expand the chemical boundaries of organic synthesis, and lay the foundation for the development of new materials and drugs.
In summary, 5-bromo-2- (4-bromophenyl) pyridine, with its unique structure and properties, plays a key role in the fields of medicine, materials and organic synthesis, and promotes technological innovation and development in various fields.