5-Bromo-2,3-dimethylpyridine

5-Bromo-2,3-dimethylpyridine is also an organic compound. It has a wide range of uses and has important applications in various fields.
First in the field of medicinal chemistry. This compound is often a key intermediate for the synthesis of drugs. Due to its unique chemical structure, it can be constructed through a series of chemical reactions with specific pharmacological activities. Taking the synthesis of some antibacterial drugs as an example, 5-bromo-2,3-dimethylpyridine can be used as a starting material. Through ingenious reaction design, other functional groups can be introduced to shape drug molecules that have inhibitory or killing effects on specific pathogens, providing help for human resistance to diseases.
Furthermore, it also has its own influence in the field of materials science. In the preparation of organic optoelectronic materials, 5-bromo-2,3-dimethylpyridine can participate in the synthesis of polymers or small molecule materials with special optoelectronic properties. Such materials may have good luminescence properties or excellent charge transport capabilities, and are expected to be applied to cutting-edge technologies such as organic Light Emitting Diodes (OLEDs) and solar cells, promoting the progress of materials science.
In addition, it also has its uses in the field of pesticide chemistry. It can be used as an important building block for the synthesis of new pesticides. By reacting with other chemical substances, pesticide ingredients that are highly effective in controlling crop pests are generated, and such ingredients may have the advantages of low toxicity, high efficiency, and environmental friendliness, which contributes to the sustainable development of agriculture.
From this perspective, although 5-bromo-2,3-dimethylpyridine is an organic compound, its role in many fields such as medicine, materials, and pesticides cannot be underestimated, and it has contributed greatly to the development of related industries.

The synthesis method of 5-bromo-2,3-dimethylpyridine covers several ways. One method can be started from the corresponding pyridine derivative. First, take a suitable pyridine substrate, which contains modifiable groups in its structure, such as halogen atoms or alkyl groups, etc., and perform bromination and methylation steps by means of organic chemistry.
At the time of bromination, choose an appropriate brominating reagent, such as N-bromosuccinimide (NBS). Under suitable reaction conditions, such as in inert solvents, with specific catalysts and temperature controls, bromine atoms are selectively introduced into the 5-position of the pyridine ring. Among them, the choice of solvent is very critical, and carbon tetrachloride is commonly used, because it can provide a stable reaction environment and help the reaction proceed smoothly.
As for the methylation step, methylation reagents can be used, such as iodomethane. In the presence of bases, methyl groups can be substituted for hydrogen atoms at the corresponding positions on the pyridine ring to achieve the 2,3-dimethyl structure. There are many types of bases, such as potassium carbonate, whose function is to activate the substrate and make the reaction more likely to occur.
Another method can start from the raw materials containing the pyridine ring and use the cyclization reaction to construct the target molecular structure. The chain-like precursor compounds with suitable substituents are first prepared, and the structural design needs to satisfy the molecular cyclization under specific conditions. Through suitable catalysts and reaction conditions, the chain-like compounds are cyclized to form pyridine rings. At the same time, bromine atoms and methyl groups are introduced through subsequent reactions during or after cyclization. The conditions of the
cyclization reaction need to be carefully regulated, and the temperature, reaction time and catalyst dosage all have significant effects on the yield and selectivity of the reaction. Although this synthesis method has different steps, it is necessary to carefully select the reagents and conditions according to the principles of organic chemistry to achieve the purpose of efficient synthesis of 5-bromo-2,3-dimethylpyridine.

5-Bromo-2,3-dimethylpyridine is one of the organic compounds. It has specific physical properties, which are listed below:
- ** Properties **: At room temperature, this substance is mostly colorless to light yellow liquid, which is clear and transparent. The formation of this property is determined by the interaction and arrangement of atoms within its molecular structure. The combination of bromine atoms, methyl groups and pyridine rings in its molecule gives the molecule a specific spatial configuration and electron cloud distribution, which in turn affects the intermolecular forces, resulting in such a phase state.
- ** Boiling point **: between 195 and 200 ° C. The value of the boiling point is closely related to the strength of the intermolecular forces. In the 5-bromo-2,3-dimethylpyridine molecule, the electronegativity of the bromine atom is relatively large, which can cause the molecule to produce a certain polarity, forming a dipole-dipole force; at the same time, the presence of methyl also affects the intermolecular van der Waals force. The combination of various forces determines its boiling point in this range.
- ** Melting point **: About -20 ° C. The melting point also depends on the intermolecular force and lattice energy. In the solid state, the molecules are arranged in an orderly manner to form a lattice, and the intermolecular force maintains the stability of the lattice. The structural characteristics of the 5-bromo-2,3-dimethylpyridine molecule enable its lattice to reach equilibrium with the intermolecular forces at this temperature, so the melting point is this value.
- ** Solubility **: In organic solvents such as ethanol, ether, dichloromethane, etc., it exhibits good solubility. This is because the molecular structure of the compound has a certain hydrophobicity, which is in line with the non-polar or weak polar of organic solvents. According to the principle of "similar miscibility", the molecules can interact with each other through van der Waals forces, making it easily soluble in such solvents. However, its solubility in water is poor. Due to the large difference between the strong polarity of water molecules and the relatively weak polarity of 5-bromo-2,3-dimethylpyridine molecules, it is difficult to form an effective interaction between the two, so it is not easily soluble in water.
- ** Density **: about 1.38g/cm ³. The size of the density depends on the mass of the molecule and the degree of compactness of the intermolecular accumulation. In the 5-bromo-2,3-dimethylpyridine molecule, the relative atomic weight of the bromine atom is larger, which increases the weight of the molecule. At the same time, the spatial structure of the molecule determines the way of intermolecular accumulation. The two work together to cause the density to exhibit this value.

5-Bromo-2,3-dimethylpyridine is also an organic compound. It has the structure of halogenated pyridine, which shows unique chemical properties due to the presence of bromine atoms and dimethyl groups.
In terms of nucleophilic substitution reactions, bromine atoms are active and can be replaced by many nucleophilic reagents. For example, when reacted with alkoxides, bromine can be replaced by alkoxy groups to form corresponding ether compounds; when reacted with amines, amine-substituted products are obtained. This is because the bromine atom is affected by the electronic effect of the pyridine ring, the carbon-bromine bond is easily broken, and the nucleophilic reagents are easily attacked.
In metal-catalyzed reactions, 5-bromo-2,3-dimethylpyridine is also an important substrate. For example, under palladium catalysis, it can be coupled with boric acid compounds to form carbon-carbon bonds. This reaction is widely used in the field of organic synthesis and can prepare complex organic molecular structures.
Furthermore, the alkalinity of the pyridine ring allows the compound to form salts with acids, which has important applications in separation, purification and drug development. At the same time, due to the power supply of methyl, the distribution of electron clouds in the pyridine ring is affected, so the reactivity at different positions on the ring is different. The adjacent and para-sites are affected by methyl, and the electron cloud density is relatively high. In electrophilic substitution reactions, it may be more likely to occur at these locations. In short, 5-bromo-2,3-dimethylpyridine has a significant role in organic synthesis and related fields due to its special structure and rich chemical properties.

The price of 5-bromo-2,3-dimethylpyridine in the market often varies according to quality, supply and demand, and purchase quantity. In the example of "Tiangong Kaiwu", the price of various things in the world varies. If this compound is of high quality, less supply and more demand, and the purchase quantity is very small, its price may be high. However, if the quality is average, the supply is sufficient, and the purchase quantity is quite large, the price should be cheaper.
In today's market, the price of 5-bromo-2,3-dimethylpyridine per gram may range from tens of yuan to hundreds of yuan. If purchased in bulk, the price per kilogram may range from several thousand yuan. However, this is only an approximate number, and the actual price must be based on the current market situation. Between sales, it is also necessary to carefully check the quality and agree on the price to achieve a win-win situation. Therefore, if you want to know the exact price, you must consult the merchant and decide according to the current market conditions.