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What is the main use of 5-Bromo-2- (2-methyl-2H-tetrazol-5-yl) pyridine?
5-Bromo-2- (2-methyl-2H-tetrazole-5-yl) pyridine is one of the organic compounds. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the creation of new drugs. The unique structure of the gaintetrazole group and the pyridine ring endows the compound with specific biological activities and pharmacological properties, or can act on specific biological targets, which has potential value in the treatment of diseases.
In the field of materials science, it can also be used. For example, it may participate in the preparation of materials with special properties, such as optoelectronic materials. With the properties of bromine atoms and heterocyclic structures in its structure, it can adjust the electron cloud distribution and intermolecular forces of the material, thus endowing the material with novel optical and electrical properties.
In addition, in the field of organic synthetic chemistry, this compound is an important synthetic building block, which can be connected with other organic molecules through various chemical reactions, such as coupling reactions, substitution reactions, etc., to construct more complex organic compound structures, providing an important basic raw material for organic synthetic chemists to explore the synthesis path of new compounds.
What are the synthesis methods of 5-Bromo-2- (2-methyl-2H-tetrazol-5-yl) pyridine
The synthesis method of 5-bromo-2- (2-methyl-2H-tetrazolium-5-yl) pyridine, although it is not contained in the ancient book "Tiangong Kaiwu", according to the ancient chemical synthesis ideas, it can be compared to similar compounds.
First look at its structure, containing a pyridine ring, a bromine atom and a tetrazolium group. Pyridine rings are commonly found in coal tar and some natural products, and can be formed by condensation and cyclization of corresponding raw materials. Bromine atoms are introduced and used in organic synthesis, often by halogenation reaction. The construction of tetrazolium groups can follow the classical tetrazolium synthesis path. < Br >
or pyridine derivatives can be prepared first, and bromine atoms can be introduced under suitable reaction conditions with appropriate halogenating reagents, such as brominating agents. Temperature, solvent and catalyst are all key. The bromination reaction conditions may need to be carefully regulated to avoid side reactions.
Then, a tetrazole group-containing fragment can be synthesized, and a nitrogen-containing raw material, such as azide and nitrile compounds, can be reacted in a suitable medium to form a tetrazole ring. The reaction of azide and nitrile requires a specific catalyst and reaction environment to promote the smooth progress of the reaction.
Finally, the bromine-containing pyridine fragment and the tetrazole fragment are connected by a coupling reaction. Coupling reaction or transition metal catalysts, such as palladium, copper, etc., select suitable ligands and bases to create a suitable reaction atmosphere, so that the two can be effectively combined to produce the target product 5-bromo-2 - (2-methyl-2H-tetrazolium-5-yl) pyridine.
The whole synthesis process requires fine planning of each step of the reaction, considering the reaction conditions, raw material ratio, intermediate product purification and many other factors, in order to obtain it efficiently.
What are the physical properties of 5-Bromo-2- (2-methyl-2H-tetrazol-5-yl) pyridine
5-Bromo-2- (2-methyl-2H-tetrazolium-5-yl) pyridine, which is an organic compound. Looking at its physical properties, it is mostly solid at room temperature and pressure. Its melting point value often varies according to the degree of purification and purity, but it is generally within a specific temperature range.
As for solubility, in organic solvents, such as common ethanol, dichloromethane, N, N-dimethylformamide (DMF), etc., it shows certain solubility characteristics. In ethanol, due to the interaction between the polarity of ethanol and some groups of the compound, it can be moderately dissolved, but the solubility is also affected by factors such as temperature. In dichloromethane, the compound can also be dispersed to a certain extent due to the weak polarity and specific structure of dichloromethane. In DMF, a strong polar organic solvent, its solubility may be relatively higher, because the strong polarity of DMF can interact more strongly with many polar groups of the compound.
When it comes to appearance, pure or white to white-like crystalline powder, depending on the molecular arrangement and crystal structure. If it contains impurities, the color may change, and the appearance may be different.
In addition, the physical properties of the compound, such as density and vapor pressure, are also closely related to the molecular structure and intermolecular forces. Its density depends on the degree of molecular packing compactness, and the vapor pressure reflects the equilibrium state of the molecule in the gas phase and the condensed phase, and shows corresponding changes under different temperature conditions.
In summary, the physical properties of 5-bromo-2 - (2-methyl-2H-tetrazolium-5-yl) pyridine are significantly affected by structure and external conditions, and these properties are crucial in chemical research and related application fields.
What are the chemical properties of 5-Bromo-2- (2-methyl-2H-tetrazol-5-yl) pyridine
5 - Bromo - 2 - (2 - methyl - 2H - tetrazol - 5 - yl) pyridine, this is an organic compound. Its chemical properties are unique, let me elaborate.
First talk about its physical properties. At room temperature, it is mostly in solid form. As for the color, it can be white to light yellow powder, but it also varies slightly depending on the synthesis method and purity. Its melting point is very critical and can be accurately determined by a melting point tester. According to relevant studies, its melting point range may be in a specific range, which helps to determine its purity and characteristics. < Br >
Re-discussion of chemical properties, the presence of bromine atoms in this compound makes it have the characteristics of halogenated hydrocarbons. Bromine atoms are highly active and easily participate in nucleophilic substitution reactions. Under suitable reaction conditions, nucleophilic agents can attack the carbon atoms connected to bromine atoms, causing bromine atoms to leave and form new compounds. The 2-methyl-2H-tetrazole-5-group in the molecule also has special reactivity. The tetrazole ring has a certain basic nature and can react with acids to form corresponding salts.
And because of the conjugated system of pyridine rings, this compound exhibits certain stability and electronic effects. The nitrogen atom of the pyridine ring can participate in the coordination reaction and form complexes with metal ions, which may have potential applications in catalysis, materials science and other fields. In the field of organic synthesis, this compound can be used as a key intermediate to construct more complex organic molecular structures through a series of chemical reactions due to its multi-activity check point.
In addition, its solubility varies in different solvents. It may have a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide, which has a great impact on its reaction operation and separation and purification.
This 5 - Bromo - 2 - (2 - methyl - 2H - tetrazol - 5 - yl) pyridine has rich and diverse chemical properties, providing a broad space for organic chemistry research and related fields of application.
What is the price range of 5-Bromo-2- (2-methyl-2H-tetrazol-5-yl) pyridine in the market?
The price of 5-bromo-2 - (2-methyl-2H-tetrazole-5-yl) pyridine in the market is difficult to determine. The price varies due to many reasons, such as the quality of the goods, the amount of purchases, the supply and demand of the market, and the differences between producers and sellers.
Taste, if the quality is good and the purchase quantity is quite large, the price may be slightly cheaper; if the quality is average and the purchase quantity is small, the price may be slightly higher. And in different places, the price is also different. In prosperous cities and remote areas, the price is often different.
However, the price per gram may be between tens of gold and hundreds of gold. However, this is only an approximate number. The actual price needs to be consulted in detail by producers and sellers, or in the chemical market and e-commerce platform to get a more accurate price. And the market conditions are impermanent, and the price changes at any time, so the price in real time must be subject to the recent inquiry.