5-bromo-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

5-Bromo-1H-pyrrolido [2,3-c] pyridine-2-carboxylic acid, an organic compound with specific chemical properties. Its appearance is often solid, the color may vary with purity, the pure product may be nearly white, or yellowish when it contains impurities.
From the perspective of physical properties, the melting point is a key characteristic. Due to the specific intermolecular forces, it changes from solid to liquid at a certain temperature. This melting point value helps to identify and purify the compound, and can be accurately measured in the laboratory with a melting point meter.
Solubility is also an important property. In organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), its solubility is quite good. Due to the interaction between the structure of the compound and the organic solvent molecules, such as van der Waals force, hydrogen bond, etc., it can be uniformly dispersed in it. In water, the solubility is limited, and the hydrophobic part of its structure accounts for a large proportion.
In terms of chemical properties, the carboxyl group activity is significant. It can neutralize with bases to form corresponding carboxylates and water. Taking sodium hydroxide as an example, the reaction generates 5-bromo-1H-pyrrolido [2,3-c] pyridine-2-carboxylate sodium and water. This reaction is often used in organic synthesis to prepare carboxylic salts, which have unique roles in certain reactions or application scenarios.
Carboxylic groups can also participate in esterification reactions. Under acid catalysis, react with alcohols to form esters and water. For example, under concentrated sulfuric acid catalysis with methanol, form 5-bromo-1H-pyrrolido [2,3-c] pyridine-2-carboxylic acid methyl esters and water. This reaction introduces ester functional groups for organic synthesis, and ester compounds are widely used in fragrance, drug synthesis and other fields.
In addition, the activity of bromine atoms should not be underestimated. Nucleophilic substitution reactions can occur, such as in the presence of appropriate nucleophiles, bromine atoms can be replaced by other groups. Taking sodium cyanide as an example, bromine atoms can be replaced by cyanyl groups to form cyanide-containing compounds. This is an important method for organic synthesis to construct new carbon-nitrogen bonds. Cyanyl groups can be further converted into other functional groups, such as carboxyl groups, amino groups, etc., which greatly expand the organic synthesis path.

The common methods for the synthesis of 5-bromo-1H-pyrrolido [2,3-c] pyridine-2-carboxylic acid are various. One is to use a suitable pyridine derivative as the starting material, introduce bromine atoms through halogenation reaction, and then in the pyrrole ring construction stage, with suitable reagents and conditions, realize the construction of pyrrolido-pyridine structure, and then perform carboxylation reaction to form the target product. During halogenation, the appropriate halogenating agent and reaction environment must be selected to ensure that the bromine atoms fall precisely into the 5th position. < Br >
There are also pyrrole derivatives as the starting point, the pyrrole ring is first modified, and then cyclized to form a pyrrolido-pyridine structure, followed by bromination and carboxylation steps. At the time of cyclization, the reaction conditions need to be fine-tuned to ensure the smooth and accurate structure of the cyclization.
There are also other heterocyclic compounds that start from other heterocyclic compounds and gradually approach the target structure through multi-step transformation. For example, through rearrangement and substitution reactions between heterocyclic rings, intermediates with similar structures are first prepared, and then modified by bromination and carboxylation to finally obtain 5-bromo-1H-pyrrolido [2,3-c] pyridine-2-carboxylic acid.
All synthesis methods require careful consideration of the reaction conditions at each step. Factors such as temperature, solvent, catalyst, etc., all affect the success or failure of the reaction and the purity and yield of the product. When implementing, the optimal synthesis path must be carefully selected according to the characteristics of the starting material, available reagents and equipment, in order to achieve the purpose of efficient and high-quality synthesis.

5-Bromo-1H-pyrrolo [2,3-c] pyridine-2-carboxylic acid is an organic compound that has applications in many fields.
In the field of medicinal chemistry, it is a key intermediate in drug synthesis. Due to its unique chemical structure, it can be converted into biologically active substances through specific chemical reactions. For example, it can be used to synthesize drugs targeting specific disease-related targets, or as lead compounds for structural modification and optimization to improve drug activity, selectivity and pharmacokinetic properties, and to assist in the development of new drugs.
In the field of materials science, such nitrogen-containing heterocyclic carboxylic acid compounds can participate in the preparation of functional materials. It can be complexed with metal ions to form metal-organic framework (MOFs) materials. These materials have potential applications in gas adsorption and separation, catalysis, etc. due to their high specific surface area and adjustable pore structure. 5-bromo-1H-pyrrolo [2,3-c] pyridine-2-carboxylic acid as an organic ligand can endow MOFs materials with unique electronic properties and spatial structures, expanding their application range.
In the field of organic synthesis chemistry, as an important starting material or intermediate, it participates in the construction of many complex organic molecules. Through various organic reactions, such as nucleophilic substitution and coupling reactions, organic compounds with novel structures and diverse functions can be synthesized by linking with other organic fragments, providing new paths and options for the development of organic synthetic chemistry and promoting the continuous expansion and innovation of this field.

5-Bromo-1H-pyrrolo [2,3-c] pyridine-2-carboxylic acid, Chinese name or 5-bromo-1H-pyrrolo [2,3-c] pyridine-2-carboxylic acid. The market price of this product is really difficult to determine. The price is influenced by many factors, which cannot be hidden in one word.
The price of the raw material for the synthesis of this acid, if the various raw materials required for the synthesis of this acid, the price will rise and fall from time to time. If the raw material is scarce, the price will become expensive, and the price of this acid will also rise; conversely, if the raw material is abundant, the price may decline.
The simplicity of the process is also related to the price. To prepare this acid, if the process is exquisite, the process is short, and the manpower and material resources required are small, the cost will drop and the price will be low; if the process is complicated, multiple steps are required, and many equipment and reagents are required, the cost will increase greatly, and the price will be high.
Market supply and demand is particularly critical. If the demand for this product is strong, many pharmaceutical companies and chemical companies are competing for it, but the supply is limited, the price will rise; if the demand is weak and the supply is full, the merchant will sell it for promotion or reduce its price.
Furthermore, the scale of production also has an impact. Large-scale production, or can take advantage of the scale effect, dilute the cost, the price may be close to the people; small-scale production, the cost is difficult to reduce, and the price is also difficult to lower.
As for the specific price, it varies from time to time, place to place, and market conditions. Or you need to consult chemical raw material suppliers and reagent sellers in detail, and compare multiple quotations to know the approximate market price. However, this price is not constant, and you need to pay attention often to get the latest price information.

5 - bromo - 1H - pyrrolo [2,3 - c] pyridine - 2 - carboxylic acid is an organic compound. In terms of its safety, this compound needs to be strictly followed by operators in laboratory settings. Because of its potential chemical activity, or it is harmful to the human body. For example, avoid direct contact, because it may irritate the skin and eyes. If you come into contact inadvertently, you should immediately rinse with plenty of water and seek medical attention according to the specific situation. When operating, it should be carried out in a well-ventilated place, preferably in a fume hood, to prevent inhalation of its dust or volatiles. If inhaled, it may cause respiratory discomfort or even more serious health problems.
In terms of stability, the compound has a certain stability under normal environmental conditions if it is properly stored. However, it is necessary to avoid high temperature, open flame and strong oxidizing agent, because at high temperature or in contact with strong oxidizing agent, or chemical reaction may occur, resulting in decreased stability or danger. When storing, it should be placed in a cool, dry place and sealed to prevent moisture and deterioration. If mixed with a specific chemical substance or unstable due to chemical reaction, it is necessary to carefully consider its compatibility with other substances when using it. Relevant pre-experiments should be done before the experiment to ensure the safety and stability of the reaction system.