5-bromo-1H-pyrazolo[3,4-c]pyridine

5-Bromo-1H-pyrazolo [3,4-c] pyridine is important in the fields of medicine and chemical industry.
It is a key intermediate in the way of pharmaceutical research and development. Taking the creation of new anti-cancer drugs as an example, this compound can be connected to a specific active group through a series of reactions, and then a molecular structure with targeted anti-cancer activity can be constructed. Due to its unique chemical structure, it can precisely act on specific targets in cancer cells, block the proliferation signaling pathway of cancer cells, or induce cancer cell apoptosis, opening up new avenues for cancer treatment.
It also plays an important role in the chemical industry. In organic synthetic chemistry, it is often used as a starting material or key module to construct complex organic molecules. By reacting with various reagents such as nucleophilic substitution and cyclization, functional materials with diverse structures can be prepared. For example, in the synthesis of optoelectronic materials, compounds derived from them may have unique optical and electrical properties, which are expected to be applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve their performance.
5-bromo-1H-pyrazolo [3,4-c] pyridine shows great application potential in the fields of medicine and chemical industry due to its unique structure, providing an important material basis and research direction for the development of related fields.

The synthesis method of 5-bromo-1H-pyrazolo [3,4-c] pyridine has been studied many times. The synthesis of this compound has a common number of paths.
First, it can be obtained by coupling a pyrazole-containing structural substrate with a bromine-containing pyridine derivative under suitable reaction conditions. First, take a specific pyrazole raw material, add an appropriate amount of base as a catalyst in a suitable solvent, heat it up to an appropriate temperature, then slowly drop the bromine-containing pyridine reactant, and continue to stir the reaction. In the meantime, pay close attention to the reaction process, which can be monitored by thin-layer chromatography. When the raw material point disappears, the reaction is almost complete. After the reaction is completed, the pure product can be obtained by conventional post-processing methods, such as extraction, washing, drying, column chromatography separation, etc.
Second, the strategy of constructing pyrazolopyridine rings can be used. First prepare key structural fragments, such as specific substituted pyridine derivatives, and add nitrogen-containing heterocyclic construction reagents, such as hydrazine compounds or their derivatives, to a specific reaction system. Under specific acid-base conditions and temperatures, the pyrazole ring is gradually constructed. During the process, the reaction parameters, such as reaction time, temperature, and proportion of reactants, are adjusted according to the characteristics of the substrate. When the pyrazolopyridine ring is initially formed, bromine atoms are introduced under suitable conditions. In the bromination step, suitable brominating reagents, such as N-bromosuccinimide (NBS), are often selected, reacted under suitable solvent and catalytic conditions, and also purified after post-treatment to obtain the target product 5-bromo-1H-pyrazolo [3,4-c] pyridine.
Or there are other methods, but they all need to be based on the actual situation, considering the availability of raw materials, cost, difficulty of reaction conditions and other factors, and carefully choose to achieve the purpose of efficient synthesis.

5-Bromo-1H-pyrazolo [3,4-c] pyridine is one of the organic compounds. Its physical and chemical properties are unique, and its detailed investigation is of great significance in the fields of chemistry.
In terms of its physical properties, under normal temperature and pressure, 5-bromo-1H-pyrazolo [3,4-c] pyridine is mostly in a solid state, but its exact physical form may vary depending on the purity and preparation method. The determination of its melting point and boiling point is the key basis for identifying and purifying this substance. After experiments, it can be obtained that the melting point of this substance is quite considerable, and it needs a specific temperature to melt into a liquid state. As for the boiling point, it also needs considerable temperature conditions to make it gasify.
Looking at its solubility, 5-bromo-1H-pyrazolo [3,4-c] pyridine exhibits certain solubility in many organic solvents. For example, in common solvents such as ethanol and dichloromethane, it can be moderately dissolved. However, its solubility in water is poor. Due to the relative lack of hydrophilic groups in the molecular structure of the compound, the hydrophobic part dominates, making it insoluble in water.
Another word about its chemical properties, the bromine atom activity of 5-bromo-1H-pyrazolo [3,4-c] pyridine is quite high. Due to the strong electronegativity of bromine atoms, the electron cloud density of the connected carbon atoms decreases, making them vulnerable to the attack of nucleophilic reagents. In the nucleophilic substitution reaction, bromine atoms can be easily replaced by other nucleophilic groups, such as hydroxyl groups, amino groups, etc., so that a series of derivatives can be synthesized. And its pyrazolopyridine structure gives this substance a certain alkalinity, which can react with acids to generate corresponding salt compounds. This acid-base property provides an opportunity for the construction of new compounds and the regulation of molecular activity in the fields of organic synthesis and medicinal chemistry. The unique physicochemical properties of 5-bromo-1H-pyrazolo [3,4-c] pyridine lay the foundation for its wide application in organic synthesis, drug research and development, etc.

What is the price of 5-bromo-1H-pyrazolo [3,4-c] pyridine in the market? This is a fine chemical raw material, and its price often varies depending on the purity, source, and supply and demand.
If purchased from a common chemical reagent, if its purity is analytical purity, about 98%, the price per gram may be in the tens of yuan. Those with analytical purity are mostly used for scientific research experiments, and impurities are strictly controlled. The preparation method is also complex, so the price is higher.
However, if it is industrial grade, the purity is slightly inferior, about 95%. Because it can be used for industrial synthesis, the dosage is large, and the price per gram may be reduced to several yuan. This is because the industrial grade has a slightly wider tolerance for impurities and a slightly lower preparation cost.
Furthermore, if purchased from a domestic manufacturer, the price may be lower than that of imports from abroad due to the elimination of many intermediate transshipment and tariffs. And market supply and demand also affect its price. If demand is strong and supply is limited, the price will rise; conversely, if supply exceeds demand, the price will drop. Therefore, to know the exact price, it is necessary to consult various suppliers in detail and compare their quotations to obtain an accurate number.

There are many patents related to 5-bromo-1H-pyrazolo [3,4-c] pyridine, and here are a few examples to illustrate.
has patents focusing on the synthesis method of such compounds. For example, by ingeniously designing the reaction path and selecting specific starting materials, under suitable reaction conditions, 5-bromo-1H-pyrazolo [3,4-c] pyridine can be efficiently prepared. This patented method can improve the purity and yield of the product, reduce cumbersome steps, and is of great significance in industrial production.
also has patents focusing on the application of this compound in the field of medicine. After research, it has been found that its structural properties make it potentially biologically active, or it can be used as a lead compound for the development of new drugs, such as anti-cancer and anti-viral drugs. Through structural modification and optimization, the structure-activity relationship is explored to find drug molecules with better efficacy and less side effects.
Another patent focuses on its derivatization reaction. Using the activity of 5-bromo-1H-pyrazolo [3,4-c] pyridine bromide atoms, react with different nucleophiles to construct a variety of derivatives. These derivatives may have unique uses in materials science, organic synthesis and other fields, such as the preparation of materials with special optoelectronic properties.
The existence of patents has promoted the research and application development of 5-bromo-1H-pyrazolo [3,4-c] pyridine, opened up new paths for related fields, and led to broader prospects.