5 Bromo 1 Methyl 1h Pyrrolo 2 3 B Pyridine
pyridine pyrrole pyrazine piperidine piperazine

5-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine

    Specifications

    HS Code

    234287

    Name 5-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine
    Molecular Formula C8H7BrN2
    Molecular Weight 211.06
    Appearance Typically a solid (physical state can vary depending on conditions)
    Melting Point Data may vary, check literature for exact value
    Boiling Point Data may vary, check literature for exact value
    Solubility Solubility characteristics can vary with solvents, needs further study
    Density Data may vary, check literature for exact value
    Pka Data may vary, check literature for exact value
    Reactivity Reactive towards reagents suitable for aromatic substitution and N - related reactions

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    General Information
    Where to Buy 5-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine in China?
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    Frequently Asked Questions

    As a leading 5-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 5-bromo-1-methyl-1H-pyrrolo [2,3-b] pyridine?
    5-Bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine, this is an organic compound. Its physical properties are unique. Under normal temperature and pressure, it is mostly solid, and its appearance may be white to pale yellow crystalline powder. The lid is due to its molecular structure, in which various atoms interact with chemical bonds, resulting in appropriate intermolecular forces, and then presents this shape.
    Looking at its melting point, it is about 100-105 ° C. This characteristic is determined by the stability of its molecular structure and the attractive force between molecules. When heated, the molecule obtains enough energy to overcome the attractive force between molecules, and the lattice structure disintegrates, so it changes from solid state to liquid state.
    In terms of solubility, this compound is slightly soluble in water. Due to its limited molecular polarity, it is difficult to form strong interactions with water molecules, such as hydrogen bonds. However, it has good solubility in organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). Due to the polarity and molecular structure of these organic solvents, it can form suitable interactions with the compound, such as van der Waals force, dipole-dipole interaction, etc., to help it disperse in the solvent.
    In addition, its density is about 1.5-1.6 g/cm ³, which is related to its molecular weight and the way of molecular packing. The molecular mass is large and it is tightly packed in the crystal structure, so the density is high. And its stability is also worth mentioning, under conventional conditions, it has a certain stability. When it encounters strong oxidants, strong acids, strong bases, etc., or chemical reactions occur, its structure changes. Because of the active checking points of bromine atoms and nitrogen atoms in the molecule, it can participate in a variety of chemical reactions, affecting its stability.
    What are the main uses of 5-bromo-1-methyl-1H-pyrrolo [2,3-b] pyridine?
    5-Bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine, an organic compound, has a wide range of uses and shows important value in various fields.
    In the field of medicinal chemistry, it is often a key intermediate. By ingeniously modifying and transforming its structure, a variety of bioactive compounds can be created. For example, when developing new anti-tumor drugs, based on this, specific functional groups can be added by chemical synthesis, which is expected to be targeted and can precisely act on tumor cells to inhibit their growth and spread. In the research and development of drugs for the treatment of neurological diseases, drugs that regulate neurotransmitters and repair nerve damage can also be developed by derivatization of them.
    In the field of materials science, the compound also has potential applications. Due to its specific molecular structure and electronic properties, it can be applied to organic optoelectronic materials. For example, after rational design and synthesis, it can be introduced into the organic Light Emitting Diode (OLED) material system, which may improve the luminescent properties of the material, improve the luminous efficiency and stability of the device, and make the display screen image quality better and lower energy consumption.
    In the field of pesticide chemistry, 5-bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine can be used as a lead compound. After structure optimization and activity screening, it is expected to develop new pesticides with high efficiency, low toxicity and environmental friendliness. Such pesticides may have high selective toxicity to specific pests, which can effectively control crop diseases and insect pests, reduce the harm to non-target organisms and reduce the negative impact on the ecological environment.
    In summary, 5-bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine is an important raw material and research object in many fields such as medicine, materials, pesticides, etc. It is of great significance to promote scientific and technological progress and industrial development in related fields.
    What are the synthesis methods 5-bromo-1-methyl-1H-pyrrolo [2,3-b] pyridine?
    The synthesis method of 5-bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine covers a variety of methods. First, pyrrolido [2,3-b] pyridine is used as the starting material, and a 1-methyl group can be introduced through methylation reaction. Among them, appropriate methylating reagents, such as iodomethane, are selected. Under suitable reaction conditions, such as in the presence of a base, the base can help the reaction proceed smoothly and achieve methylation.
    Then, a bromination reaction is carried out to introduce 5-bromo atoms. Commonly used bromination reagents, such as N-bromosuccinimide (NBS), in a suitable reaction system, such as an inert solvent, light or the addition of an initiator, can prompt the bromination reaction to occur efficiently, resulting in the target product 5-bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine.
    Another way is to construct the parent nuclear structure of pyrrolido [2,3-b] pyridine by a multi-step cyclization reaction with a pyridine derivative containing a specific substituent as the starting material. In the process of constructing the parent nucleus, the reaction conditions, such as temperature, reactant ratio, etc., are precisely regulated, so that methyl and bromide atoms are introduced in sequence or at the same time, and reach the expected substitution position. Although this method may be complicated, the reaction of each step can be flexibly adjusted to obtain the ideal product yield and purity. In a word, the synthesis of this compound requires careful selection of an appropriate synthesis route according to actual conditions and needs.
    What are the precautions for storing 5-bromo-1-methyl-1H-pyrrolo [2,3-b] pyridine?
    5-Bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine is an organic compound, and many matters need to be paid attention to during storage.
    First, be sure to pay attention to the temperature and humidity of the storage environment. This compound is quite sensitive to temperature and humidity, and high temperature or high humidity environment can easily cause it to deteriorate. If the temperature is too high, it may cause changes in molecular structure and accelerate the progress of chemical reactions; if the humidity is too high, it may cause it to absorb moisture, which in turn affects its purity and stability. Therefore, it should be stored in a cool and dry place, the temperature should be maintained at 2-8 ° C, and the humidity should be controlled at 40% -60%.
    Second, light will also affect it. The compound may be photosensitive, exposed to light for a long time, or lead to luminescent chemical reactions, causing its structure to change and activity to decrease. Therefore, when storing, it needs to be protected from light. It can be placed in a brown bottle or stored in a place where direct light is difficult.
    Third, the choice of storage container is also crucial. Containers with stable chemical properties and no reaction with the compound should be selected. Containers such as glass are often preferred because of their good chemical stability. However, it should be noted that some glass may contain alkaline substances. If it comes into contact with the compound, it may cause adverse reactions. At this time, specially treated glass containers can be used, or plastic containers can be used, but it is necessary to ensure that the plastic material does not interact with the compound.
    Fourth, to prevent contact with other chemical substances. This compound has specific chemical activity, contact with certain substances, or chemical reactions may occur, causing it to deteriorate. Therefore, it should be stored separately to avoid coexistence with oxidizing agents, reducing agents, acids, alkalis and other substances.
    Fifth, during storage, it needs to be checked regularly. Check for changes in appearance, such as color changes, precipitation, etc.; check whether its purity and content meet requirements. Once an abnormality is found, immediate measures should be taken or the compound should be discarded to avoid affecting subsequent use.
    What is the market outlook for 5-bromo-1-methyl-1H-pyrrolo [2,3-b] pyridine?
    5-Bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine, this product has considerable market prospects at present. It has emerged in the field of pharmaceutical and chemical industry and has a wide range of uses.
    Looking at pharmaceutical research and development, it is an important intermediate. Today, the development of many innovative drugs has an increasing demand for specific structural compounds. The unique structure of 5-bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine is exactly what is needed for the creation of new drugs. Many pharmaceutical companies and scientific research institutions have invested a lot of effort in this, leveraging its structural properties to explore the possibility of anti-cancer, antiviral and neurological diseases treatment drugs, and the market demand has risen.
    In the chemical industry, it can participate in the synthesis of high-performance materials. With the rapid development of materials science, the demand for materials with special properties has surged. 5-Bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine can impart special electrical, optical or mechanical properties to materials, and has unlimited potential in the manufacture of electronic and optical materials, which has attracted many chemical companies to get involved in related R & D and production.
    Furthermore, global scientific research progress is closely linked to market dynamics. In academic research, new properties and new synthetic methods of these compounds continue to emerge, injecting new impetus into their market expansion. Optimization of synthetic methods can reduce production costs, improve product quality, and further enhance market competitiveness.
    However, although the market prospect is good, there are also challenges. The complexity of the synthesis process makes the production difficulty and cost remain high. And the industry competition is fierce, in order to take the lead in the market, enterprises need to continuously improve their technical level and optimize their production processes in order to adapt to market changes and enjoy the opportunities brought by the broad market prospect of 5-bromo-1-methyl-1H-pyrrolido [2,3-b] pyridine.