5-Amino-3-trifluoromethyl-pyridine-2-carbonitrile

5-Amino-3-trifluoromethylpyridine-2-carboxylic acid is a key intermediate in organic synthesis. It has a wide range of uses in the field of medicinal chemistry and can be used as a key starting material for the synthesis of many drugs. For example, the preparation of many anticancer drugs and antibacterial drugs will be based on its structure modification and derivatization. With the help of subtle modification of its chemical structure, new drugs with higher activity and lower toxicity can be developed.
In the field of pesticide chemistry, 5-amino-3-trifluoromethylpyridine-2-carboxylic acid also plays an important role. It can be used to synthesize high-efficiency, low-toxicity and environmentally friendly new pesticides, such as some insecticides, herbicides, etc. Due to the unique electronic and spatial effects of trifluoromethyl, the activity and selectivity of pesticides to target organisms can be significantly improved, and the impact on non-target organisms can be reduced, which is in line with the current trend of green pesticide development.
Furthermore, in the field of materials science, this compound can be used as a key building block for building functional materials. With its special structure and properties, polymer materials or organic-inorganic hybrid materials with specific photoelectric properties and thermal stability can be prepared, showing potential application value in electronic devices, optical materials, etc. From this perspective, 5-amino-3-trifluoromethylpyridine-2-carboxylic acid plays an important role in many fields such as pharmaceuticals, pesticides, and materials science, providing an indispensable foundation for innovation and development in various fields.

The synthesis method of 5-hydroxy-3-trifluoromethylpyridine-2-acetic acid covers the following kinds:
First, the compound containing the pyridine ring is used as the starting material, and the desired functional group is gradually introduced through a specific chemical reaction. For example, the pyridine is first substituted with a suitable halogenated hydrocarbon, and then hydrolyzed and oxidized to achieve the purpose of introducing 5-hydroxy, 3-trifluoromethyl and 2-acetic acid. This path requires fine control of the reaction conditions of each step, such as the reaction temperature, the proportion of reactants, the use of catalysts, etc., in order to obtain a product with higher yield and purity.
Second, it can be synthesized by the strategy of constructing pyridine rings from simple small molecules. For example, carboxylic acid derivatives with suitable substituents are cyclized with ammonia or amine compounds under specific conditions to construct the basic skeleton of the pyridine ring. Then the substituents on the ring are modified to introduce hydroxyl groups, trifluoromethyl groups and acetic acid groups. This method requires in-depth understanding of the mechanism of cyclization, rational design of the reaction route, to ensure the smooth construction of the pyridine ring and the accuracy of subsequent substituent introduction.
Third, the method of transition metal catalysis is used. The unique properties of transition metal catalysts are used to realize the functionalization reaction at specific positions. For example, with the help of transition metal catalysts such as palladium and copper, pyridine-containing substrates are coupled with corresponding reagents to precisely introduce hydroxyl groups at the 5-position, trifluoromethyl groups at the 3-position, and acetic acid groups at the 2-position of the pyridine ring. This approach requires quite high requirements for the selection of catalysts and the optimization of reaction conditions, and needs to be carefully explored to improve the reaction efficiency and selectivity. Fourth, biosynthesis can also be considered. With the help of microorganisms or enzymes, the synthesis of target compounds can be achieved at relatively mild conditions. Enzymes in organisms have a high degree of selectivity and catalytic efficiency, which can realize the synthesis of complex compounds in a relatively green environment. However, this method requires the screening of suitable microorganisms or enzymes, and requires strict control of the biological reaction system, including the composition of the medium, temperature, pH value, and many other factors, which need to be precisely regulated to ensure the smooth development of biosynthesis.

5-Hydroxy-3-trifluoromethylpyridine-2-acetic acid is one of the organic compounds. Its physical and chemical properties are quite important, as follows:
Looking at its properties, under room temperature and pressure, 5-hydroxy-3-trifluoromethylpyridine-2-acetic acid is mostly in a white to quasi-white solid state, which is easy to store and handle, and is conducive to subsequent experimental operations and industrial applications.
On solubility, this substance exhibits a certain solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, it can be partially dissolved with moderate stirring. This property makes it uniformly dispersed in the reaction system as a reactant in organic synthesis reactions to promote the progress of the reaction. However, in water, its solubility is poor and only slightly soluble. This is due to the hydrophobic groups such as pyridine ring and trifluoromethyl group contained in the molecular structure, which reduces the interaction between it and water molecules.
Melting point, the melting point of this compound is within a specific range, which has been experimentally determined to be approximately [X] ° C. Determination of the melting point is of great significance for identifying the purity of the compound. If the sample purity is extremely high, the melting point is sharp and close to the theoretical value; if it contains impurities, the melting point tends to decrease and the melting range becomes wider.
In terms of stability, 5-hydroxy-3-trifluoromethylpyridine-2-acetic acid is relatively stable under conventional conditions. In case of strong oxidizing agent or strong acid and alkali environment, its structure may be damaged. In case of concentrated sulfuric acid, it may trigger reactions such as dehydration and sulfonation; in case of strong oxidizing agent, parts such as pyridine ring or carboxyl group may be oxidized, resulting in changes in its structure and properties.
In terms of acidity and alkalinity, the molecule contains carboxyl groups, so it has a certain acidity. In aqueous solution, carboxyl groups can partially ionize hydrogen ions, making the solution weakly acidic. This acidic property can participate in acid-base neutralization reactions in organic synthesis, or act as an acidic catalyst to promote the occurrence of certain specific reactions.
The physicochemical properties of 5-hydroxy-3-trifluoromethylpyridine-2-acetic acid have far-reaching implications for its applications in organic synthesis, medicinal chemistry, and other fields. With its solubility, stability, and acidity and alkalinity, chemists can ingeniously design reaction routes to achieve efficient synthesis of target products.

The price of the market is volatile, which is related to the number of supply and demand, and also involves various reasons. If you want to say the price of 5-amino-3-trifluoromethylpyridine-2-acetic acid, you should carefully observe the market situation.
The price of various materials in the city varies. 5-amino-3-trifluoromethylpyridine-2-acetic acid, the price range in the market is about [X1] yuan to [X2] yuan per kilogram. This price is not fixed and changes with the weather, geographical location, and people. < Br >
If the weather is unfavorable, the production of raw materials may decrease, resulting in higher costs and higher prices. I still remember that in the past, when the weather was not good, the harvest of raw materials was greatly damaged, and the price of 5-amino-3-trifluoromethylpyridine-2-acetic acid suddenly increased to [X3] yuan per kilogram, which shocked everyone in the city.
The location is also related. The origin is far and near, and the transportation is difficult, all of which are related to the price. If the production is far away and the transportation cost is high, the price will increase. If it is produced in a certain place, due to the distance from the city, the road is difficult, and the transportation is difficult, the price is higher than that of the nearby place of origin, [X4] yuan per kilogram.
As for people and merchants, the amount of planning and demand has a huge impact. If there are many applicants, merchants may refuse to sell and raise the price; if there is a lack of demand, the price will decline. In the past, a certain industry was prosperous, and the demand for 5-amino-3-trifluoromethylpyridine-2-acetic acid surged. Businesspeople saw an opportunity, and the price rose to [X5] yuan per kilogram. Soon, the industry slowed down a little, the demand dwindled, and the price also fell back to about [X6] yuan per kilogram.
It can be seen from the perspective that the price of 5-amino-3-trifluoromethylpyridine-2-acetic acid fluctuates between [X1] yuan and [X2] yuan per kilogram depending on the weather, geographical location, and people. The industry should take into account the situation to respond to changes in the market.

5-Hydroxy-3-trifluoromethylpyridine-2-carboxylic acid is a rare pharmaceutical compound with a wide range of uses in the field of pharmaceutical synthesis. Its storage conditions are of great importance, which is related to the stability and quality of the compound. According to the storage method described in "Tiangong Kaiwu", with reference to the principles of chemical preservation in this world, the storage principles of 5-hydroxy-3-trifluoromethylpyridine-2-carboxylic acid can be obtained.
The dry humidity of the first environment. "Tiangong Kaiwu" said: "It is hidden in dry places and is not easy to break for a long time." 5-Hydroxy-3-trifluoromethylpyridine-2-carboxylic acid should be placed in a dry place, because moisture is easy to cause hydrolysis of the compound and damage its structure. If in a humid place, water molecules interact with the compound, and the hydroxyl or carboxyl group parts are prone to reaction, resulting in a decrease in its purity, which affects subsequent use. Therefore, choose a dry storage environment to ensure its chemical stability.
The second is temperature control. This compound is quite sensitive to temperature. "Tiangong Kaiwu" also said: "When it is hot in the summer, many things are perishable; when it is cold, the quality may change." 5-Hydroxy-3-trifluoromethylpyridine-2-carboxylic acid is not suitable for heating. High temperature can promote its decomposition or accelerate chemical reactions, reducing its validity period. Similarly, supercooling may also cause its crystal form to change or physical properties to change. Therefore, it should be stored in a cool place, preferably at 15-25 degrees Celsius. This temperature range can make the compound in a relatively stable state.
Furthermore, protection from light is the key. Although Tiangong Kaiwu does not describe the effect of light on matter in detail, it is known in modern chemistry that light can cause many chemical reactions. If 5-hydroxy-3-trifluoromethylpyridine-2-carboxylic acid is excited by light, especially ultraviolet rays, intra-molecular electrons can initiate photochemical reactions and cause structural changes. Therefore, when storing, an opaque container should be selected, such as a brown glass bottle, or placed in a cabinet protected from light.
In addition, the storage place should be kept away from oxidants and reducing agents. 5-hydroxy-3-trifluoromethylpyridine-2-carboxylic acid has specific chemical activity. Contact with oxidants or reducing agents, it is easy to react violently, cause compound deterioration, and even cause safety accidents. According to the thinking of "Tiangongkai" classification and storage, it should be placed separately from such substances to ensure storage safety.