5-Amino-3-(trifluoromethyl)-2-pyridinecarbonitrile

5-Amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid is an important organic compound with a wide range of main uses.
In the field of medicinal chemistry, it is a key intermediate. It can be cleverly combined with other chemical groups through specific chemical reaction steps to construct molecular structures with specific pharmacological activities. Taking the development of some new anti-hypertensive drugs as an example, by modifying and modifying the structure of the compound, the ability of the drug to bind to specific receptors can be precisely adjusted, thereby optimizing the efficacy and selectivity of the drug, improving the therapeutic effect of the drug, and reducing the chance of adverse reactions.
In the field of materials science, 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid also plays an important role. Due to its unique molecular structure endowing special chemical and physical properties, it can be used as a raw material for the synthesis of functional materials. For example, when preparing high-performance optical materials, the compound can participate in the reaction to form a polymer with specific optical properties, so that the material exhibits excellent fluorescence properties or photochromic effects, and has potential application value in many optoelectronic devices such as optical sensors and Light Emitting Diodes.
In the research and development of pesticides, this compound is also indispensable. After rational design and synthesis, new pesticides can be created. Its special structure helps to enhance the biological activity and targeting of pesticides against specific pests or pathogens, improve the control effect of pesticides, and reduce the impact on non-target organisms in the environment. It helps to develop green and environmentally friendly pesticides, which meets the needs of sustainable development of modern agriculture.

To prepare 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid, it can be obtained from the following ancient methods.
First, pyridine is used as the base, and trifluoromethyl is introduced first. Pyridine can be reacted with trifluoromethylation reagents, such as trifluoromethyl magnesium halide, in a suitable solvent with the help of a catalyst, and nucleophilic substitution can be carried out. After the trifluoromethyl group is firmly attached to the third position of the pyridine ring, it is reacted with an amination reagent, such as an ammonia derivative, such as sodium azide, first with a pyridine halide to obtain a azide. After reduction, such as treatment with a reducing agent such as lithium aluminum hydride, the azide group can be converted to an amino group. As for the carboxyl group, it can be obtained by methyl oxidation. Under suitable conditions, the methyl group in the second position of the pyridine ring is changed to a carboxyl group.
Second, a pyridine derivative containing a carboxyl group is used as the starting material. If there are already pyridine-2-carboxylic acids, the carboxyl group can be protected first to prevent it from being disturbed in subsequent reactions, such as esterification to form an ester. Then trifluoromethyl groups are introduced at the third position, such as electrophilic reagents containing trifluoromethyl groups, and substituted under suitable catalyst and reaction conditions. After the trifluoromethyl groups are successfully connected, amino groups are introduced at suitable check points. Halogenation can be carried out first, and then ammoniolysis can be carried out. Halogenation reagents such as N-halogenated succinimide are used to make the pyridine ring suitable for check point halogenation, and then react with ammonia or its derivatives to achieve amination. Finally, the carboxyl protecting group is removed, and the ester is hydrolyzed with alkali to obtain the target 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid.
Third, to construct the strategy of pyridine ring. Suitable precursors containing amino, carboxyl and trifluoromethyl can be selected to construct the pyridine ring through condensation and cyclization reactions. For example, with compounds containing amino and carbonyl groups, and substances containing trifluoromethyl groups and functional groups that can react with carbonyl groups, under the catalysis of acids or bases, through multi-step condensation and cyclization reactions, pyridine rings are directly constructed, and each substituent is located in a suitable position. After appropriate modification, the morphology of amino and carboxyl groups is improved to obtain the final product.

5-Hydroxy-3- (trifluoromethyl) -2 to its methyl ether is an organic compound with specific physical and chemical properties.
Looking at its physical properties, under normal conditions, this compound is mostly white to light yellow crystalline powder with fine texture. Its melting point is [specific value]. At this temperature, the substance changes from solid to liquid state. This property is crucial in the separation, purification and identification of compounds. Its purity can be determined by melting point measurement. In terms of boiling point, under [specific pressure], the boiling point is [specific value]. This boiling point data is of great significance for controlling the conditions of compounds during separation operations such as distillation.
When it comes to solubility, 5-hydroxy-3- (trifluoromethyl) -2-to its methyl ether is soluble in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In dichloromethane, it can be uniformly dispersed in a certain proportion to form a clear solution, which is due to the interaction between the polarity of dichloromethane and the structure of the compound, so that the molecule can be stably dispersed. In water, its solubility is poor, because its molecular structure contains hydrophobic trifluoromethyl and other groups, which hinder the formation of effective interactions with water molecules.
Chemically, the hydroxyl group in this compound is relatively active. The oxygen atom in the hydroxyl group has a solitary pair electron and is easy to react with electrophilic reagents. When encountering an acyl chloride, the hydroxyl oxygen atom will attack the carbonyl carbon of the acyl chloride, and an acylation reaction will occur to form the corresponding ester compound. At the same time, the strong electron-absorbing property of trifluoromethyl reduces the electron cloud density of the benzene ring, which weakens the electrophilic substitution reaction activity on the benzene ring. If the nitration reaction is carried out, compared with benzene, more severe reaction conditions are required, and the substitution position is also affected by the positioning effect of trifluoromethyl and hydroxyl group. Methoxy group, as a power supply group, has a certain activation effect on the benzene ring, but due to the strong electron-absorbing effect of trifluoromethyl, the overall benzene ring activity is still lower than that of common phenolic compounds. Under alkaline conditions, the hydroxyl group may undergo deprotonation to form the corresponding phenate anion, which can participate in the reaction as a nucleophile in organic synthesis.

I look at what you are asking, but I am inquiring about the price range of 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid in the market. This compound is used more and more widely in today's world, so the price is also controlled by many factors.
If you look at its source, if it comes from a famous factory, its quality is pure and strict, and the price may be slightly higher. The price of the product made by Xiaofang is cheap, but the quality is unknown. And the amount of its demand is also related to the price. If there are many users, the demand is greater than the supply, and the price will rise; if the user is rare, the supply will exceed the demand, and the price will be depressed.
Furthermore, the dynamics of the market are like changes in the wind and clouds. Sometimes the price of materials rises, causing its cost to increase, and the price also rises; sometimes the process innovation, the cost drops, and the price may fall.
Now as far as I know, the price of this 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid per gram, or between tens of gold and hundreds of gold. However, this is only an approximate number, and the actual price should be carefully judged according to the current market conditions, the state of supply and demand, and the quality of the goods. The market situation is changeable. If you want to know the exact price, you need to ask the merchants in detail to check the real-time price.

The storage conditions of 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid are crucial to the quality and efficacy of this medicine. According to the thinking of "Tiangong Kaiwu", the storage of materials needs to be determined according to its properties and let it be.
This material quality is either afraid of moisture, heat, and easy to change in response to various things. Therefore, when hiding, it is best to place it in a dry place. The moisture is dense, which is easy to cause deliquescence, damage its structure, and lose its effectiveness. Just like an ancient collection of books, it is placed in a dry place in a pavilion to prevent moth and mildew. The same is true for this substance.
Next time, it is appropriate to place in a cool place. High temperature can promote its chemical reaction to speed up, or cause decomposition and deterioration. For example, the ancient brew, hidden in the cool place of the cellar, makes the wine alcohol and unchanged, this 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid should also be protected from heat and cool.
and should be kept alone, not mixed with other things. Because of or in response to it, the properties change. If the ancient alchemy, various medicines are different, and if they are not combined properly, they will fail. This substance also needs to be prevented from mixing with other substances and changing.
In summary, the storage of 5-amino-3- (trifluoromethyl) -2-pyridinecarboxylic acid is suitable in a dry, cool and isolated place, so that it can be stored for a long time for future use.