5-Amino-2-cyano-3-(trifluoromethyl)pyridine

5-Amino-2-cyano-3- (trifluoromethyl) pyridine has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. Due to the structure of pyridine containing trifluoromethyl, it has made great contributions to enhancing drug activity and improving pharmacokinetic properties in many drug molecules. With its unique chemical properties, 5-amino-2-cyano-3- (trifluoromethyl) pyridine can participate in a variety of chemical reactions to synthesize compounds with specific biological activities. For example, when developing new therapeutic drugs for certain diseases, it is often used as a starting material to build a core structure through multi-step reactions.
In the field of pesticide chemistry, it also has important applications. Pyridine compounds play a significant role in the creation of pesticides. 5-amino-2-cyano-3- (trifluoromethyl) pyridine has special functional groups, which can give pesticides such as high efficiency, low toxicity, and environmental friendliness. Based on it, new insecticides, fungicides or herbicides can be developed to help agricultural pest control and improve crop yield and quality.
In addition, in the field of materials science, this compound has also emerged. Due to the special atoms and groups in its structure, it can give materials specific electrical, optical or chemical properties. For example, in the synthesis of organic optoelectronic materials, the introduction of this structure may improve the photoelectric conversion efficiency and stability of materials, providing new possibilities for the development of organic electronic devices. In short, 5-amino-2-cyano-3- (trifluoromethyl) pyridine has important uses in many important fields due to its unique structure and chemical properties, which is of great significance to promote the development of related fields.

The synthesis method of 5-amino-2-cyano-3- (trifluoromethyl) pyridine is a crucial exploration in the field of chemical synthesis. In the past, various paths were often followed to prepare this compound.
First, it can be started from the starting material containing the pyridine ring. For example, the pyridine derivative with a suitable substituent is first taken, and the cyano group is introduced at the designated position of the pyridine ring through a specific substitution reaction. This method of cyano introduction, or nuclear substitution, reacts with pyridine derivatives with cyano-containing reagents, and skillfully controls the reaction conditions, such as temperature, solvent and catalyst selection, so that the cyano group precisely falls at the target check point.
Then, trifluoromethyl is introduced. The usual method is to react with the cyanide-containing pyridine intermediate under suitable conditions with a reagent containing trifluoromethyl, such as a trifluoromethylation reagent. In this step, the activity and selectivity of the catalyst are extremely important, and careful selection is required to ensure that the trifluoromethyl is successfully attached to the predetermined position on the pyridine ring and to avoid adverse effects on the existing groups.
As for the introduction of amino groups, it can be achieved in the subsequent steps by nucleophilic substitution or reductive amination with an appropriate amination reagent. For example, an amine compound is reacted with a precursor, and the amino group is substituted for the corresponding group under specific conditions to obtain the target product 5-amino-2-cyano-3- (trifluoromethyl) pyridine.
There is another synthesis method, which starts with the construction of the pyridine ring. First, the pyridine ring structure is constructed by cyclization of a small molecule compound containing a specific functional group. During the cyclization process, the structure and reaction conditions of the reactants are cleverly designed, so that the pyridine ring is formed with groups that can be further derived into cyano, trifluoromethyl and amino groups. Subsequent modifications are made according to the conventional method of conversion of each group to complete the synthesis of the target compound. This approach requires a deep understanding of the cyclization reaction mechanism and precise control of the reaction process in order to obtain this product efficiently.
The method of synthesizing 5-amino-2-cyano-3- (trifluoromethyl) pyridine, or gradually introducing groups from pyridine derivatives, or first constructing a pyridine ring and then modifying it, requires chemists to carefully study the reaction conditions and reagent selection in order to achieve the ideal synthesis effect.

5-Amino-2-cyano-3- (trifluoromethyl) pyridine is an important compound in organic chemistry. Its physical properties are unique and crucial in scientific research and chemical industry.
This compound is often white to off-white crystalline powder in appearance, fine in texture, and has a certain luster when viewed with the naked eye. Its melting point is in a specific range, about [X] ° C. The exact value of the melting point is an important basis for identifying the compound. In the process of synthesis and purification, the purity of the product can be judged by melting point measurement.
Furthermore, the solubility of 5-amino-2-cyano-3- (trifluoromethyl) pyridine also has characteristics. In common organic solvents, such as ethanol, dichloromethane, etc., it has a certain solubility. In ethanol, with the increase of temperature, the solubility increases gradually. This property is conducive to selecting a suitable solvent to promote the reaction in organic synthesis. In water, its solubility is relatively low, which is related to the ratio of polar and non-polar groups contained in its molecular structure.
In addition, the density of the compound is about [X] g/cm ³, which is a physical parameter that is of great significance in experiments and industrial production involving mass and volume conversion. And its stability is good, under conventional storage conditions, it can maintain its chemical structure and properties unchanged for a long time, but it is necessary to avoid high temperatures, open flames and strong oxidizing agents to prevent dangerous chemical reactions.

I look at the "5 - Amino - 2 - cyano - 3 - (trifluoromethyl) pyridine" you asked about. The market price of this product is difficult to determine for a variety of reasons.
First, the difficulty of its preparation affects the price. If the preparation requires cumbersome steps, special raw materials and harsh conditions, the cost will rise and the price will also be high. If rare reagents are required in the preparation, or the reaction is under specific temperature, pressure and catalyst, the cost will increase significantly.
Second, the amount of market demand determines the price. If this compound is widely used in the fields of medicine, pesticides, materials, etc., the demand is strong, and the supply is limited, the price will rise; on the contrary, if the demand is low, the price will stabilize or decline.
Third, the differences in manufacturers also have an impact. Different manufacturers have different production processes, scales, and cost controls, and their pricing is also different. Large-scale manufacturers, due to scale effects, may reduce costs and have competitive prices; while small-scale manufacturers have higher costs and relatively high prices.
Furthermore, purity is also the key. High purity "5 - Amino - 2 - cyano - 3 - (trifluoromethyl) pyridine" is indispensable in some high-end application scenarios, and its price is naturally higher than that of ordinary purity.
After checking the past data, the exact market price cannot be obtained. For details, you can consult chemical product suppliers, traders, or refer to professional chemical product price information platforms, so that relatively accurate price information may be available.

5-Amino-2-cyano-3- (trifluoromethyl) pyridine is one of the organic compounds. Its storage conditions are crucial to the stability and quality of this substance.
This substance should be stored in a cool, dry and well-ventilated place. A cool environment can keep the temperature not too high to prevent it from changing its chemical properties due to heat or triggering adverse reactions such as decomposition. A dry environment is also indispensable, because moisture is easy to interact with the compound, or cause hydrolysis and other changes, which can damage its purity and characteristics. Well-ventilated can avoid the accumulation of harmful gases and ensure the safety of storage space.
In addition, when storing, it should be kept away from fire and heat sources. Both fire and heat sources can cause a sudden rise in temperature, trigger chemical reactions, and even cause the risk of combustion and explosion. It should also be stored separately from oxidizing agents, acids, alkalis and other substances. These substances have different chemical activities. If they are mixed in one place, they are prone to chemical reactions, resulting in deterioration of the substance and the growth of dangerous conditions.
Storage containers should also be carefully selected. When using a sealed container to prevent it from coming into contact with the air, avoid oxidation or absorption of moisture in the air. And the container material is also careful, so as not to react with the compound, so as not to affect its quality.
When handling this substance, it should also be handled lightly to avoid collision and friction. This compound may be damaged due to severe collision and friction, which may affect its storage state or cause safety accidents.
In summary, following appropriate storage conditions can ensure the quality and safety of 5-amino-2-cyano-3- (trifluoromethyl) pyridine, so that it can play its due role in subsequent applications.