5-amino-2-bromopyridine

5-Amino-2-bromopyridine is one of the organic compounds. It has many physical properties, let me tell you in detail.
Looking at its properties, under normal temperature and pressure, 5-amino-2-bromopyridine is mostly white to light yellow crystalline powder. This form is easy to store and use, and is also quite suitable for many chemical operations.
When it comes to melting point, it is between 126 ° C and 128 ° C. Melting point is an important physical property of a substance. This specific melting point indicates that the compound will undergo a solid-to-liquid transformation at a specific temperature range. This property is of great significance in material identification and purity judgment.
In addition to solubility, 5-amino-2-bromopyridine is slightly soluble in water. This property is derived from the degree of interaction between its molecular structure and water molecules. However, it is soluble in common organic solvents, such as ethanol, dichloromethane, etc. Good solubility in organic solvents facilitates its use in organic synthesis reactions, and many reactions can be carried out smoothly in suitable solvent environments.
Its density is also an important physical property. Although the exact value may vary slightly due to different measurement conditions, it is generally within a certain range. Density is related to the relationship between substance mass and volume, and plays a key role in practical applications, such as the ratio of reactants to materials.
The physical properties of 5-amino-2-bromopyridine are of great significance in many fields such as organic synthesis and drug development. In the synthesis, the appropriate reaction medium can be selected according to the solubility, and the melting point helps to control the reaction process and product purity. All the physical properties are interrelated, which together constitute the unique position of this compound in the chemical world.

5-Amino-2-bromopyridine is one of the organic compounds. Its chemical properties are very impressive, and I will give you a detailed description.
First of all, its alkalinity. The amino group in the molecule has a solitary pair electron, so it can combine with protons and is alkaline. Although its alkalinity is weaker than that of aliphatic amines due to the distribution of electron clouds in the pyridine ring, it can still form salts in a suitable acidic environment, which is why it dissolves in acid solution.
On its nucleophilic substitution reaction. The position of the amino group and the bromine atom makes the molecule have unique reactivity. Bromine atoms are good leaving groups. When encountering nucleophiles, nucleophilic substitution reactions are prone to occur. Nucleophiles can attack carbon atoms connected to bromine, and bromine ions leave to form new compounds. This reaction is often used in organic synthesis to construct new carbon-heteroatom bonds.
To talk about its reaction with metal-organic reagents. 5-Amino-2-bromopyridine can react with metal-organic reagents, such as Grignard reagents or lithium reagents. Such reagents can react with halogen atoms on the pyridine ring to form carbon-metal bonds, and then react with various electrophilic reagents to realize the functionalization of the pyridine ring. It has a wide range of uses in the synthesis of complex organic molecules.
Furthermore, amino groups can participate in many reactions. For example, they can be acylated with acyl halide or acid anhydride to form amide compounds. This reaction not only protects amino groups, but also is an important way to construct compounds containing amide bonds.
5-amino-2-bromopyridine has diverse chemical properties due to its unique chemical structure. It is a key intermediate for the preparation of various functional compounds in the field of organic synthesis and has important application value.

The main synthesis methods of 5-amino-2-bromopyridine cover the following kinds.
One is halogenation. First, pyridine is used as the initial raw material, and it is reacted with appropriate amination reagents to introduce amino groups to generate 5-amino pyridine. In this process, suitable reaction conditions, such as temperature, pressure and catalyst, need to be selected to ensure the smooth progress of the amination reaction. Then, 5-amino pyridine is reacted with brominating reagents to introduce bromine atoms at the second position of the pyridine ring to obtain 5-amino-2-bromopyridine. In this bromination step, the choice of brominating reagents and the control of reaction conditions are very critical, which will affect the purity and yield of the product.
The second is to start with pyridine derivatives containing specific substituents. For example, select a pyridine compound with suitable substituents and facilitate subsequent conversion, and gradually build the target molecular structure through a series of organic reactions, such as substitution reactions and functional group conversion. This approach requires careful consideration of the structural design of the starting material, and precise control of the sequence and conditions of each step of the reaction, in order to efficiently synthesize 5-amino-2-bromopyridine.
Furthermore, the coupling reaction catalyzed by transition metals is also a commonly used method. Amino-containing pyridine derivatives and bromine-containing reagents can be selected for coupling reaction under the action of transition metal catalysts. Transition metal catalysts can activate reaction substrates and promote the formation of chemical bonds. This method has high requirements for the selection of catalysts, the use of ligands and the optimization of the reaction system. However, it has the advantages of good reaction selectivity and relatively mild conditions, which is conducive to improving the quality and yield of the product.
In short, there are various methods for synthesizing 5-amino-2-bromopyridine, and each method has its own advantages and disadvantages. In practical application, the appropriate synthesis path needs to be carefully selected according to specific needs and conditions.

5-Amino-2-bromopyridine is useful in many fields. In the field of pharmaceutical chemistry, it is a key raw material for the synthesis of miraculous medicines. Taking antibacterial drugs as an example, their unique chemical structure can be delicately reacted and integrated into drug molecules, giving drugs special antibacterial activity, or as a weapon against stubborn bacteria.
In the field of materials science, it also has extraordinary potential. By chemical modification, it can be introduced into polymer materials to improve the electrical and optical properties of materials. For example, it can be used to prepare special optoelectronic materials, or it can be used in optoelectronic devices to demonstrate excellent photoelectric conversion efficiency, which will contribute to the development of new display technologies and optical communication equipment.
In the field of organic synthesis, it is an important synthetic building block. Chemists can design exquisite reaction routes according to the activity of amino and bromine atoms, build complex and diverse organic compounds, expand the boundaries of organic synthesis, and open up infinite possibilities for exploring new substances and new structures.
In agricultural chemistry, it may participate in the synthesis of new pesticides. Through rational molecular design, pesticides are given better insecticidal, bactericidal or herbicidal properties, and have the characteristics of high efficiency, low toxicity and environmental friendliness, providing strong chemical support for the sustainable development of modern agriculture.

5-Amino-2-bromopyridine, an important compound in organic chemistry, is widely used in the fields of medicine, pesticides and materials. As for its market price, it is difficult to give an exact value, because it is affected by many factors.
The first to bear the brunt is the market supply and demand. If the market has strong demand for 5-amino-2-bromopyridine and relatively scarce supply, its price will rise; conversely, if supply exceeds demand, the price will easily fall.
Furthermore, the cost of production also affects the price. The price of raw materials, the difficulty of production processes, and the amount of energy consumption are all related to costs. If the raw materials are scarce and expensive, or the production process is complicated, a lot of manpower and material resources need to be invested, the cost will be high, and the price will also rise.
The purity and quality of the product are also key. High purity and high quality 5-amino-2-bromo pyridine, due to the difficulty of preparation, the price is often higher than that of ordinary quality.
In addition, regional differences cannot be ignored. Different regions have different levels of economic development, market competition, transportation costs, etc., resulting in different prices. Generally speaking, in economically developed areas, due to the large market demand and fierce competition, the price may be relatively stable; while in remote areas, due to the increase in transportation costs, the price may be slightly higher.
Overall, the market price of 5-amino-2-bromopyridine fluctuates frequently, ranging from a few dollars per gram to tens of dollars per gram or even higher. For accurate prices, you can consult relevant chemical product suppliers, traders, or browse professional chemical product trading platforms for the latest price information.