5 6 Dichloro 3 Hydroxypyridine
pyridine pyrrole pyrazine piperidine piperazine

5,6-Dichloro-3-hydroxypyridine

    Specifications

    HS Code

    452874

    Chemical Formula C5H3Cl2NO
    Molar Mass 164.0
    Appearance Solid
    Color White to off - white
    Melting Point 136 - 140 °C
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, acetone
    Odor May have a faint, characteristic odor
    Purity Typically sold at high purity (e.g., 95%+)
    Stability Stable under normal conditions

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    General Information
    Where to Buy 5,6-Dichloro-3-hydroxypyridine in China?
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    Frequently Asked Questions

    As a leading 5,6-Dichloro-3-hydroxypyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5,6-dichloro-3-hydroxypyridine?
    5% 2C6-dioxy-3-furanylpyridine, although not detailed in Tiangongkai, has a wide range of uses in today's chemical field. Its main uses are as follows:
    First, in the synthesis of medicine, 5% 2C6-dioxy-3-furanylpyridine is often a key intermediate. Due to its unique chemical structure and activity, it can participate in many complex organic reactions and assist medical chemists in constructing special pharmacoactive groups. For example, in the synthesis of some antibacterial drugs, this is used as a starting material and modified by a series of reactions to obtain drug molecules with high inhibitory activity against specific bacteria, which can add a powerful weapon to human disease fighting.
    Second, in the field of materials science, it also has outstanding performance. Due to the special electrical and optical properties endowed by the molecular structure, it can be used to prepare organic optoelectronic materials. For example, in the research and development of organic Light Emitting Diode (OLED) materials, the introduction of 5% 2C6-dioxy-3-furanopyridine structural units is expected to improve the luminous efficiency and stability of materials, and contribute to the progress of display technology.
    Third, in the fine chemical industry, 5% 2C6-dioxy-3-furanopyridine can be used as an important synthetic block. Chemical craftsmen can use this to synthesize a variety of high-value-added fine chemicals, such as special fragrances and additives. Taking spice synthesis as an example, its unique structure can be skillfully transformed to endow spices with unique aroma characteristics, enrich spice categories, and meet the diverse needs of the market.
    What are the physical properties of 5,6-dichloro-3-hydroxypyridine
    The physical properties of 5% 2C6 + - + dideuterium-3 -fluoromethoxypyridine are as follows:
    This compound has a specific melting and boiling point. Its melting point may vary depending on the intermolecular forces and the lattice structure. If the intermolecular forces are strong and the lattice is arranged properly, the melting point is higher; otherwise, it is lower. The boiling point is also affected by the intermolecular forces, including van der Waals forces, hydrogen bonds, etc. The strong forces cause the boiling point to rise.
    In terms of solubility, the substance behaves differently in different solvents. Because of its electronegative atoms such as fluorine and oxygen, it exhibits a certain solubility in polar solvents such as alcohols and ketones, or through hydrogen bonds and dipole-dipole interactions; in non-polar solvents such as alkanes, due to large polar differences, solubility may not be good.
    Density is one of the characteristics of a substance, depending on its molecular weight and molecular stacking method. If the molecular weight is large and the stacking is tight, the density is higher.
    The stability of this compound is also an important physical property. Fluorine atoms have high electronegativity, which can affect the distribution of molecular electron clouds and enhance the stability of some chemical bonds. However, they may also react under specific conditions due to the presence of reactive functional groups, such as nucleophilic substitution, electrophilic substitution, etc. In the presence of light, heat or catalyst, the reactivity or change.
    Its refractive index is related to the molecular structure, reflecting the change in the speed of light propagation in it, and is related to the molecular polarizability and other factors. It can be used as one of the physical constants for identifying the compound.
    In addition, the compound may have a certain volatility. Volatility is related to vapor pressure and is affected by temperature and intermolecular forces. When temperature increases, vapor pressure increases and volatility increases; when intermolecular forces are weak, volatility is also strong.
    Is the chemical property of 5,6-dichloro-3-hydroxypyridine stable?
    The chemical properties of 5,6-dioxy-3-fluoro-pyridine are still stable. Among this compound, the structure of dioxy and fluoro groups has a great influence on its properties. Oxygen atoms have high electronegativity, creating an electron cloud bias in the molecule, which changes the charge distribution of the surrounding atoms. However, this structure reaches a certain balance through multiple bonds and conjugation effects.
    Fluoryl groups also have high electronegativity and are connected to the pyridine ring. Although the electron-withdrawing effect is introduced, the molecular structure is not greatly disturbed due to the buffer of the conjugate system of the pyridine ring itself. The conjugate system acts as a stable framework, allowing the electron cloud to be reasonably dispersed and alleviating the problem of excessive activity caused by local charge concentration.
    Furthermore, the bond energy, bond length and bond angle between various atoms in the molecule are precisely adapted to form a relatively stable geometric configuration. This configuration makes the interaction between molecules in a better state, and it is difficult to cause structural collapse or reactivity to rise sharply due to slight external stimuli. Therefore, under normal conditions, the chemical properties of 5,6-dioxide-3-fluoropyridine tend to be stable, which can maintain its own structure and characteristics, and less intense chemical reactions.
    What are the synthesis methods of 5,6-dichloro-3-hydroxypyridine?
    To prepare 5% 2C6-dioxy-3-furanylcarboxylic acid, there are various synthesis methods, which are described in detail as follows:
    First, furfural is used as the starting material. After a specific oxidation reaction of furfural, the corresponding carboxylic acid derivative can be obtained. The carboxylic acid derivative and the alcohol with a specific structure are esterified under suitable catalyst and reaction conditions to form an ester intermediate. Then, the intermediate undergoes a cyclization reaction and carefully adjusts the reaction parameters, such as temperature, reaction duration, and the proportion of reactants, etc. Finally, the target product 5% 2C6-dioxy-3-furanylcarboxylic acid can be obtained. The raw materials for this route are easy to obtain, but the reaction steps are slightly complicated, and each step needs to be carefully controlled to improve the purity and yield of the product.
    Second, a specific furan derivative is selected as the starting material. First, it is functionalized and modified, and a suitable substituent is introduced. After that, the desired 5% 2C6-dioxo-3-furanylcarboxyl structure is constructed by means of intramolecular cyclization. The reaction steps of this route are relatively simple, but the selection and preparation of starting materials may be difficult, and the optimization of reaction conditions is also very critical. Precise control is required to ensure the smooth progress of the reaction and achieve a good synthesis effect.
    Third, a multi-step tandem reaction strategy can be considered. Several simple organic compounds are selected, and through ingenious reaction design, they undergo a series of reactions such as addition, cyclization, and oxidation in the same reaction system in sequence to synthesize 5% 2C6-dioxy-3-furanylcarboxyl in one step. Although this method can shorten the reaction process and improve the atomic economy, it requires extremely high synergy of reaction conditions. It is necessary to study the interaction between each reaction in depth to achieve high-efficiency and high-selectivity synthesis.
    What is the price range of 5,6-dichloro-3-hydroxypyridine on the market?
    5% 2C6 + - + dioxy + - + 3 + - + guanidine in the market, its price range varies depending on the purity of the product, supply and demand, and the method of preparation.
    At present, if this product in the market is pure, its price is about tens to hundreds of yuan per gram. However, if its purity is extremely high, it can reach the standard of special use, and the price may rise sharply, to hundreds of yuan per gram, or even more than 1,000 yuan.
    Supply and demand are also the main reasons. If the market is prosperous and the supply is limited, the price must rise; conversely, if the supply exceeds the demand, the price may drop.
    Furthermore, the method of production is also related to the price. A new and excellent law can reduce its cost, but the price is also low; while an old law may increase, and the price will also increase.
    Therefore, if you want to know its exact price, you must carefully check the market conditions and compare it with the goods and prices of various companies.