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What is the chemical structure of 5,6,7,7a-tetrahydrothieno [3,2-c] pyridine-2 (4H) -one p-toluenesulfonate
5% 2C6% 2C7% 2C7a refers to the substance tetrahydrofuro [3,2-c] pyridine-2 (4H) -one p-toluenesulfonate. In this compound, tetrahydrofuro [3,2-c] pyridine-2 (4H) -one is the main structural part, and p-toluenesulfonate is the salt part bound to it.
The structure of tetrahydrofuro [3,2-c] pyridine-2 (4H) -one. The pyridine ring is a six-membered nitrogen-containing heterocycle and has aromatic properties. The tetrahydrofuran ring fuses with the pyridine ring in a specific way in the form of the [3,2-c] union. The tetrahydrofuran ring is a five-membered saturated oxygen-containing heterocyclic ring, which is connected to the pyridine ring, so that the overall structure has the characteristics of both saturated and unsaturated heterocyclic rings. 2 (4H) -keto indicates that there is a ketone carbonyl at position 2 of the pyridine ring, and position 4 is a hydrogen atom. This ketone carbonyl group has a great influence on the chemical properties of compounds and can participate in many chemical reactions, such as nucleophilic addition reactions.
Look at the part of p-toluenesulfonate. The p-toluenesulfonate is composed of p-toluene and sulfonic acid (-SO 🥰). P-toluene is a structure with methyl groups attached to the para-position of the benzene ring, which has certain hydrophobicity. Sulfonic acid groups are strongly acidic, and they combine with tetrahydrofuran [3,2-c] pyridine-2 (4H) -one to form salts, which can enhance the solubility of compounds in water and change their physicochemical properties. This salt form is commonly found in the fields of organic synthesis and medicinal chemistry, and helps to improve the stability and solubility of compounds, so as to facilitate subsequent separation, purification and preparation operations.
What are the physical properties of 5,6,7,7a-tetrahydrothieno [3,2-c] pyridine-2 (4H) -one p-toluenesulfonate
In "Tiangong Kaiji", tetrahydrofuro [3,2-c] pyridine-2 (4H) -one shows the physical properties of acid anhydride for acetylbenzene, which are roughly as follows:
This substance has a certain melting point. The value of its melting point varies slightly depending on the degree of purity and measurement conditions, but it is roughly within a certain temperature range. This is one of the important physical properties to identify the substance.
Furthermore, its solubility is also significant. In common organic solvents, such as ethanol, ether, etc., it exhibits a specific dissolution behavior. In ethanol, the amount of solubility varies with the change of temperature, and it can be mutually soluble to a certain extent at a certain temperature. This property is crucial in the operation of separation, purification and related chemical reactions.
In addition, the density of the substance is also one of its physical properties. Its density determines its floating and sinking conditions in different liquid media, and this property plays a role in physical processes such as stratification of mixed liquids.
In appearance, tetrahydrofuran [3,2 - c] pyridine-2 (4H) -ketone p-acetylbenzene shows that the anhydride usually appears in a specific form, either crystalline or powdered, and has a certain color. This appearance property can assist in the preliminary identification of the substance.
As for its boiling point, under specific pressure conditions, it will reach the corresponding boiling point temperature, which is of great significance for separation operations such as distillation and understanding its thermal stability. Various physical properties are interrelated, and together they describe the physical characteristics of tetrahydrofuran [3,2-c] pyridine-2 (4H) -one p-acetylbenzene showing acid anhydride, which provides an important basis for its application and research in many fields such as chemical industry and medicine.
What is the main use of 5,6,7,7a-tetrahydrothiopheno [3,2-c] pyridine-2 (4H) -one p-toluenesulfonate?
The main use of 5% 2C6% 2C7% 2C7a-tetrahydrofurano [3,2-c] pyridine-2 (4H) -one for acetylsalicylic anhydride is that this compound is of great significance in the pharmaceutical field.
tetrahydrofurano [3,2-c] pyridine-2 (4H) -one can be used as a key intermediate to participate in the synthesis of acetylsalicylic anhydride-related drugs. In pharmaceutical chemistry, acetylsalicylic anhydride is often an important raw material for the preparation of a variety of antipyretic, analgesic and anti-inflammatory drugs, and 5% 2C6% 2C7% 2C7a-tetrahydrofurano [3,2-c] pyridine-2 (4H) -ketone in its synthesis path can guide the reaction towards the direction of generating the target product through a specific chemical reaction, which helps to improve the synthesis efficiency and purity of acetylsalicylic anhydride.
For example, in the development of some innovative drugs, it is necessary to use the unique chemical structure of such compounds to react with other reagents to build more complex molecular structures with specific pharmacological activities. Acetylsalicylic anhydride is a key link, and tetrahydrofuran [3,2-c] pyridine-2 (4H) -one provides indispensable support for its synthesis, which plays a key role in promoting the birth of new drugs and optimizing drug quality.
What are the synthesis methods of 5,6,7,7a-tetrahydrothieno [3,2-c] pyridine-2 (4H) -one p-toluenesulfonate
To prepare 5% 2C6% 2C7% 2C7a-tetrahydrofuro [3,2-c] pyridine-2 (4H) -ketone p-toluenesulfonyl ester, there are three methods.
First, with suitable starting materials, through a multi-step reaction, which involves ingenious functional group transformation. First, a specific group in the raw material is substituted, and key structural fragments are introduced. Then the core skeleton of tetrahydrofuro-pyridine is constructed by cyclization reaction. At this time, the skeleton is first formed, and then the hydrogen atom at a specific position needs to be selectively oxidized to form a ketone group. Finally, under mild conditions, the ketone is esterified with p-toluenesulfonyl chloride to obtain the target product. This approach requires precise control of the reaction conditions, and the yield and selectivity of each step are key. If there is a slight difference, it is difficult to achieve the goal.
Second, a stepwise splicing strategy can be adopted. First, the key intermediates of tetrahydrofuran and pyridine are synthesized separately. The synthesis of the two has its own method, which needs to be carefully operated according to chemical laws. Then, the two are connected through a specific coupling reaction to form the basic framework of the target molecule. At this time, although the framework is formed, it needs to be modified at a specific position to achieve the structure of the target product. Among them, the introduction of ketone groups and the formation of p-toluenesulfonyl esters need to be carried out under appropriate conditions to ensure the smooth progress of the reaction and the purity of the product.
Third, with the help of biomimetic synthesis ideas. Many biosynthetic processes in nature can provide inspiration for chemical synthesis. Find a natural product or biosynthetic intermediate with a structure similar to the target molecule, and use this as a starting point to simulate the chemical reaction in the organism under mild and green conditions. Use enzyme catalysis or specific biomimetic reagents to gradually convert the starting material into the target product. Although this method is challenging, if successful, it will have the advantages of high efficiency and environmental protection, and is expected to open up new paths for the synthesis of this compound.
These three have their own advantages and disadvantages, and need to be considered comprehensively according to the actual situation, such as raw material availability, cost, yield and other factors, in order to choose the best synthesis method.
What is the market outlook for 5,6,7,7a-tetrahydrothieno [3,2-c] pyridine-2 (4H) -one p-toluenesulfonate?
In "Tianwen Kaiwu", this article talks about the market prospect of 5% 2C6% 2C7% 2C7a-tetrahydrofuro [3,2-c] pyridine-2 (4H) -one p-acetylbenzenesulfonyl chloride.
This product is widely used in chemical industries in the present world. In the process of organic synthesis, it is often a key agent and can help many reactions proceed smoothly. Tetrahydrofuro [3,2-c] pyridine-2 (4H) -one, with its unique structure and unique properties, can produce different reactions in the reaction of acetylbenzenesulfonyl chloride.
In terms of market supply and demand, with the booming of the chemical industry, the demand for fine chemicals is increasing day by day. Acetylbenzenesulfonyl chloride is widely used in the fields of medicine, pesticides, and dyes. And the products produced by the reaction of 5% 2C6% 2C7% 2C7a-tetrahydrofurano [3,2-c] pyridine-2 (4H) -one with it may have new qualities and may have new uses in the above industries.
However, its prospects are not all smooth. The market competition is fierce, and the same industry is seeking development, and they want to get a share of this. And in the chemical industry, regulations are becoming stricter, and environmental protection is increasingly important. The production of this product requires legal regulations and environmental impact. If we can seek technological innovation, reduce costs and increase efficiency, meet the requirements of environmental protection, and adapt to market changes, then the market of 5% 2C6% 2C7% 2C7a-tetrahydrofurano [3,2-c] pyridine-2 (4H) -ketone p-acetylbenzenesulfonyl chloride may have a promising future. It will shine in the chemical industry and contribute to the progress of the industry.
