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What are the main application fields of 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine?
5- (4-cyano) -1H-pyrrolido [2,3-b] pyridine, this compound has important applications in medicine, materials and other fields.
In the field of pharmaceutical research and development, it shows significant potential. Due to the specific structure of the compound, it can interact with specific targets in vivo. For example, in the field of anti-tumor drug research, researchers have found that it has inhibitory effect on the growth and proliferation of some tumor cells. It can precisely act on protein targets of key signaling pathways in tumor cells, hindering the abnormal division and spread of tumor cells, providing a key infrastructure for the development of new high-efficiency anti-tumor drugs.
In the field of materials science, 5- (4-cyano) -1H-pyrrolido [2,3-b] pyridine also has unique uses. Due to its special optoelectronic properties endowed by its molecular structure, it can be applied to the preparation of organic optoelectronic devices. Like organic Light Emitting Diode (OLED), this compound can be used as a light-emitting layer material or a charge transport layer material to optimize the luminous efficiency and stability of the device. Because it can effectively regulate the charge transfer and recombination process, it can improve the performance of OLED devices, make the display picture clearer and brighter, and promote the progress of display technology.
In summary, 5- (4-cyano) -1H-pyrrolido [2,3-b] pyridine plays an important role in the field of medicine and materials, and with the deepening of research, it is expected to generate more innovative applications.
What are the synthesis methods of 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine
To prepare 5- (4-cyanophenyl) -1H-pyrrolido [2,3-b] pyridine, there are many synthesis methods, and each has its own advantages and disadvantages, often depending on factors such as raw materials, cost, yield and reaction conditions.
First, suitable halogenated pyridine and cyanophenylboronic acid as raw materials can be prepared by Suzuki coupling reaction under palladium catalysis. The reaction conditions are mild and the selectivity is good, but the palladium catalyst has a high price, which increases the cost, and requires an anaerobic environment, and the operation requirements are strict. The reaction is roughly as follows: the halogen atom of halogenated pyridine and the boron atom of cyanophenylboronic acid are coupled under the catalysis of palladium, and the bond is broken to form a bond, and the final target product is obtained.
Second, the pyridine derivative is prepared by multi-step reaction with the compound containing cyanobenzene. First, the pyridine derivative is reacted with a certain reagent at a specific position, the active group is introduced, and then reacts with the compound containing cyanobenzene. After a series of steps such as addition and elimination, the target product is obtained. This approach is cumbersome and the yield of each step affects the final result. However, the raw materials are common and easy to obtain, and the equipment requirements are low.
Third, it is synthesized by the strategy of The structure of pyrrolido [2,3-b] pyridine was constructed by selecting compounds containing the structure of pyridine and benzene with appropriate linking groups, and under suitable reagents and conditions, the molecular cyclization reaction occurred to construct the pyrrolido [2,3-b] pyridine structure. This method has high atomic economy or high, but the reaction conditions may be harsh, and special requirements for the structure of the reactants.
In actual synthesis, chemists need to analyze the advantages and disadvantages of each method in detail, combine their own conditions, and choose the optimal path to efficiently and economically prepare 5- (4-cyanophenyl) -1H-pyrrolido [2,3-b] pyridine.
What are the physicochemical properties of 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine?
5- (4-cyanobenzyl) -1H-pyrrolido [2,3-b] pyridine, this is an organic compound. Its physical and chemical properties are quite important, and it is related to many chemical and chemical application fields.
In terms of appearance, this compound is often in the state of white to light yellow solid powder, with a fine and uniform texture. This form is convenient for precise measurement and operation in various experiments and production processes.
In terms of melting point, it is about a certain temperature range, and this temperature characteristic is of great significance for the purification and identification of compounds. By measuring the melting point, the purity of the compound can be determined. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point will be reduced and the range will become wider.
Solubility is also a key property. It has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide. This solubility makes it convenient to participate in various solution-phase chemical reactions, providing many conveniences for organic synthesis. In water, its solubility is poor, due to the large proportion of hydrophobic groups in the molecular structure of the compound, which makes the force between it and water molecules weak.
In terms of stability, the compound is relatively stable at room temperature and pressure without special chemical environment interference. However, if exposed to high temperatures, strong acids and bases, or strong oxidizing agents, its structure may change, leading to chemical reactions and the formation of new compounds.
In addition, the physical and chemical properties of the compound are also reflected in its spectral properties. In the infrared spectrum, specific chemical bonds exhibit characteristic absorption peaks, which can be used to determine the functional groups contained in the molecule. In nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms in different chemical environments give unique signals to help analyze the molecular structure. These spectral properties are like the "fingerprint" of a compound, providing a strong basis for its accurate identification and structural determination.
What is the price range of 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine in the market?
I don't know what you mean by "5-%284-%E6%B0%AF%E8%8B%AF%E5%9F%BA%29-1H-%E5%90%A1%E5%92%AF%E5%B9%B6%5B2%2C3-b%5D%E5%90%A1%E5%95%B6", is this garbled or something? However, if you ask 1H-pyrrole [2,3-b] pyridine in the market price range, this is a compound in the field of fine chemicals, its price fluctuations are quite large, subject to a variety of factors.
First, the purity has a huge impact. If the purity is quite high, reaching the scientific research level, nearly 99% purity, because it can be used for high-end scientific research experiments, strict requirements for impurities, so the price is high. On the market, the price per gram may be hundreds or even thousands of yuan.
Second, the degree of mass production is also related. If the production process is mature, it can be mass-produced, the cost will be reduced, and the price will be close to the people. However, if it can only be prepared in small quantities, the process is complicated, and it consumes a lot of manpower and material resources, the price will be high.
Third, market supply and demand determine the price. If there is a large increase in demand for a while, but the supply is limited, the price will rise; if there is little demand and sufficient supply, the price will tend to decline.
From a comprehensive perspective, the price per gram for ordinary purity products may be around tens of yuan to hundreds of yuan; high-purity high-quality products may cost more than 1,000 yuan per gram. However, the market is unpredictable, and it is difficult to accurately determine. It can only be outlined according to common circumstances.
What are the safety and toxicity of 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine?
5- (4-cyanobenzyl) -1H-pyrrolido [2,3-b] pyridine, this is an organic compound. However, its safety and toxicity depend on many factors.
From the perspective of chemical structure, cyanobenzyl contains a cyanide group, which is potentially toxic. Under specific conditions, cyanyl may release cyanide ions, which can interact with many enzymes and proteins in organisms, especially inhibit cytochrome oxidase during cellular respiration, causing cells to be unable to use oxygen effectively, which can lead to serious consequences such as cell asphyxia and metabolic disorders. If a person comes into contact with cyanide-containing compounds, or absorbs them through the skin, inhales their volatiles, or eats them by mistake, there may be a risk of poisoning, and the symptoms may be mild or headache, dizziness, fatigue, nausea, vomiting, etc. In severe cases, it may cause breathing difficulties, convulsions, coma and even death.
Furthermore, the chemical activity of the 1H-pyrrolido [2,3-b] pyridine part, or participates in complex chemical reactions in the body, although it may not be as toxic as cyanyl, it may also interfere with normal physiological and biochemical processes. Its potential toxicity may be reflected in the affinity to specific biomolecules, affecting key physiological mechanisms such as cell signaling and gene expression regulation. Long-term or large exposure, or cause chronic toxic effects, such as organ damage, immune system disorders, etc.
However, its safety and toxicity are not absolute, but depend on the exposure dose, exposure route, exposure duration and individual differences. If in a strictly regulated laboratory environment, follow the correct operation procedures and take protective measures, such as wearing appropriate protective equipment and operating with good ventilation, it can effectively reduce the risk of exposure and reduce toxic hazards. And in the field of drug development and other fields, through reasonable modification and design, it may be able to reduce its toxicity, improve safety, and make it play a beneficial role in treating diseases. In conclusion, the safety and toxicity assessment of 5- (4-cyanobenzyl) -1H-pyrrolido [2,3-b] pyridine requires comprehensive consideration of multiple factors and careful treatment.