5 4 4 5 5 Tetramethyl 1 3 2 Dioxaborolan 2 Yl Pyridine 2 Carboxylic Acid Methylamide
pyridine pyrrole pyrazine piperidine piperazine

5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid methylamide

    Specifications

    HS Code

    666662

    Chemical Name 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid methylamide
    Molecular Formula C13H19BN2O3
    Molecular Weight 262.113
    Appearance Solid (likely, based on similar compounds)
    Physical State Solid at room temperature (assumed)
    Solubility Solubility in organic solvents like dichloromethane, chloroform (general prediction for similar boronate esters)
    Reactivity Reactive in cross - coupling reactions (common property of boronic acid esters)

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    Frequently Asked Questions

    As a leading 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid methylamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemical structure of 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentane-2-yl) -pyridine-2-carboxylic acid formamide
    5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentylborane-2-yl) -to its-2-carboxylphenylboronic acid The structure of this compound is more complex, let me elaborate.
    The core part of this compound revolves around phenylboronic acid. On the benzene ring, there is a structure connected to 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentylborane-2-yl), and another is connected to a 2-carboxyl group.
    Among them, the 4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane structure is a five-membered heterocyclic ring composed of one boron atom, two oxygen atoms and three carbon atoms, and there are two methyl groups connected at the 4th and 5th positions of the ring. In the phenylboronic acid part, the phenyl ring is connected to the boric acid group (-B (OH) -2), and at the same time binds the above specific structure and carboxyl groups.
    Different groups in this structure interact with each other, giving the compound unique chemical properties. Boric acid groups are often used as an important reaction check point in organic synthesis, and can participate in a variety of coupling reactions; carboxyl groups are acidic, can occur acid-base reactions and participate in esterification and other reactions; and tetramethyl- [1,3,2] dioxboron heterocyclopentaborane structure, which also regulates the stability and reactivity of compounds.
    What is the main use of 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentane-2-yl) -pyridine-2-carboxylic formamide
    5 - (4,4,5,5 - tetramethyl- [1,3,2] dioxyboron heterocyclopentane - 2 - yl) - to its - 2 - carboxylphenylboronic acid, which is mainly used as a key intermediate in organic synthesis. In the field of medicinal chemistry, it can participate in the construction of complex molecular structures with biological activity. With its unique chemical properties, it can use boron-oxygen bonds and other functional groups to achieve precise molecular construction, laying the foundation for the creation of new drugs. In the field of materials science, it may be used to prepare specific functional materials, by reacting with other monomers or compounds, giving materials special optoelectronic, mechanical and other properties. In organic synthetic chemistry, as an important synthetic building block, it can undergo various reactions, such as the Suzuki coupling reaction, and react with substrates such as halogenated aromatics or olefins to form carbon-carbon bonds, thereby expanding the molecular skeleton and synthesizing organic compounds with diverse structures, thus contributing to the development and innovation of organic synthetic chemistry.
    What are the synthesis methods of 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentane-2-yl) -pyridine-2-carboxylic acid formamide
    To prepare 5 - (4,4,5,5 - tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane - 2 - yl) - methyl pyridine - 2 - carboxylate, it can be done from the following ancient method.
    First, using methyl pyridine - 2 - carboxylate as the starting material, first halogenation reaction, the introduction of halogen atoms, such as under suitable halogenation reagents and reaction conditions, the introduction of bromine or iodine atoms at a suitable check point in the pyridine ring, this step of the reaction should pay attention to the reaction temperature, time and reagent ratio to avoid excessive halogenation. Subsequently, the halogenated pyridine-2-carboxylic acid methyl ester and tetramethyl- [1,3,2] dioxboron heterocyclopentaborane-2-based reagents are coupled under palladium catalysis. Commonly used palladium catalysts such as tetra- (triphenylphosphine) palladium, etc., and suitable bases and ligands need to be added to control the pH of the reaction system and the reaction environment, so as to promote the coupling of the two to form the target product. This route focuses on the accurate halogenation and the control of coupling reaction conditions.
    Second, the pyridine ring can be modified first, such as functionalizing the pyridine ring of pyridine-2-carboxylic acid methyl ester, and introducing an active group that can react with tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane-2-yl through a suitable reaction. Then, under specific reaction conditions, the active group is reacted with tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane-2-yl to construct the target structure. This process requires careful selection of active groups and corresponding reaction conditions to ensure the smooth progress of the reaction and avoid unnecessary side reactions.
    Thirdly, the construction of the pyridine ring and the introduction of tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane-2-based fragments were started synchronously. Appropriate raw materials were selected to construct the pyridine ring through multi-step cyclization reaction, and at the same time, tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane-2-yl was ingeniously introduced during the cyclization process. This method requires precise design of reaction steps and conditions to ensure the coordinated progress of each step, and efficient synthesis of the target product 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane-2-yl) -methyl pyridine-2-carboxylate.
    What are the physical properties of 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentane-2-yl) -pyridine-2-carboxylic formamide
    Methyl 5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentaborane-2-yl) -alkynyl-2-naphthalenecarboxylate is an organic compound with the following physical properties:
    This substance is mostly in solid form at room temperature, and in terms of stability, it is relatively stable under conventional environmental conditions. However, when encountering strong oxidizing agents, strong acids and bases, the structure may change and chemical reactions occur. In terms of solubility, it is generally difficult to dissolve in water due to the large proportion of hydrophobic groups in its molecules, which makes it difficult for water molecules to interact effectively with it. However, it is soluble in some organic solvents, such as common dichloromethane and chloroform, because its molecules have certain similarities in structure and polarity with these organic solvents, and follow the principle of "similar miscibility".
    In terms of melting point, the specific molecular structure and intermolecular forces determine that it has a certain melting point value. This physical parameter is of great significance for judging the phase state change of it at different temperatures. Compared with water, its density will vary depending on the specific structure, providing a basic data reference for the actual operation of materials such as storage and transportation. In addition, the compound may have certain volatility. Under specific temperature and pressure conditions, some molecules will evaporate from the solid surface to the gas phase. These physical properties are interrelated and affect its application and processing in many fields, such as organic synthesis and materials science.
    5- (4,4,5,5-tetramethyl- [1,3,2] dioxyboron heterocyclopentane-2-yl) -pyridine-2-carboxylic formamide What are the precautions in storage and transportation?
    I look at what you said about "5 - (4,4,5,5 - tetramethyl- [1,3,2] dioxyboron heterocyclopentyl boron - 2 - yl) -to its - 2 - carboxybenzoic acid What are the precautions in storage and transportation". This is a question related to the preservation and transportation of chemical substances, and needs to be considered in detail.
    In terms of storage, the first choice of environment. This substance should be placed in a cool and dry place, away from direct sunlight, and its quality will be damaged due to light or changes in its properties. And the temperature should be stable, extreme temperatures can cause chemical reactions and cause material deterioration.
    Furthermore, it should be stored separately from oxidizing, reducing and acid-alkaline substances. This substance may react with other chemicals, causing danger. In case of strong oxidizing agents, or violent oxidation reactions, the risk of fire and explosion; in case of acid or alkali, or chemical reactions, changing the chemical structure and properties.
    As for transportation, the packaging must be tight. Use a special container to ensure that the seal is leak-free, so as to prevent leakage from polluting the environment and endangering people. During transportation, it is also necessary to control the temperature and choose a smooth route to avoid violent vibration and collision, so as to avoid material leakage caused by container damage.
    The escort should have professional chemical knowledge and know the characteristics of this substance and emergency methods. In case of leakage, effective measures can be taken quickly to minimize the harm. In this way, 5 - (4,4,5,5 - tetramethyl- [1,3,2] boron dioxide heterocyclopentyl boron - 2 - yl) - to its - 2 - carboxybenzoic acid is safe and secure during storage and transportation.