5-(3-FLUOROPHENYL)-2-METHYLPYRIDINE

5- (3-hydroxyethyl) -2-methylpyridine is widely used in the chemical industry, pharmaceutical synthesis and other fields.
In the chemical industry, it is often used as an intermediate in organic synthesis. Taking the synthesis of fine chemicals as an example, with its unique chemical structure, it can participate in many complex organic reactions. After ingeniously designing the reaction path, it can be converted into a variety of high-value-added compounds, laying the foundation for the development and production of new materials. For example, in the preparation of some polymers with special properties, it can be used as a key monomer or modifier to endow the polymer with unique physical and chemical properties and improve material properties.
In the field of medicine, its importance is even more prominent. Many drug molecular designs will introduce this structural fragment because it has specific biological activities and pharmacological effects. In the development of some antibacterial drugs, its structural characteristics are used to enhance the ability of drugs to bind to bacterial targets and improve antibacterial effects; in the development of neurological drugs, it can affect the ability of drug molecules to pass through the blood-brain barrier and optimize the therapeutic effect of drugs on neurological diseases. Among many drug synthesis routes, 5- (3-hydroxyethyl) -2-methylpyridine is an indispensable intermediate. Through a series of chemical reactions, it is combined with other functional groups to construct drug molecules with complex structures and significant therapeutic effects.

5- (3-hydroxybenzyl) -2-methylpyridine, this substance is an organic compound. Its physical properties are quite critical, let me elaborate.
Looking at its appearance, under room temperature and pressure, it is often colorless to light yellow liquid, with a clear and transparent texture, like a clear spring, giving people a sense of purity.
When it comes to smell, it exudes a special aromatic smell. This smell is neither rich and pungent, nor elegant and difficult to find, but unique. With a little attention, you can detect it.
When it comes to solubility, it exhibits good solubility in organic solvents, such as common ethanol, ether and other organic solvents, which can be fused with it, just like the joy of fish and water, forming a uniform mixed system. However, the solubility in water is relatively poor, just like the relationship between oil and water, it is difficult to fuse intimately.
Melting point and boiling point are also important physical properties. Its melting point is in a specific low temperature range, while the boiling point is relatively high, which makes it exhibit different physical states under different temperature conditions. At lower temperatures, it can solidify into a solid state, just like water condenses into ice; and when the temperature rises near the boiling point, it will vaporize into a gaseous state and rise.
In terms of density, it is slightly less dense than water, so if it is placed in one place with water, it will float lightly on the water surface, like a boat.
In addition, it also has a certain volatility. Although it is not very volatile, under certain environmental conditions, some substances will also evaporate into the air over time.
The above physical properties are of crucial significance for in-depth understanding of the characteristics of 5- (3-hydroxybenzyl) -2-methylpyridine and its use in various practical application scenarios.

5- (3-hydroxyethyl) -2-methylpyridine, its chemical properties are relatively stable. In this compound, the structure of the pyridine ring endows it with certain aromatic properties and stability. The introduction of methyl and hydroxyethyl groups has an effect on the electron cloud distribution, but it does not significantly weaken the stability of the pyridine ring.
methyl has a electron-inducing effect, which can increase the electron cloud density on the pyridine ring. However, this effect is limited and will not destroy the conjugated system of the pyridine ring, so it has little effect on the overall stability. The hydroxyl group in the hydroxyethyl group can form intramolecular or intermolecular hydrogen bonds, which enhances the stability of the molecule to some extent.
Under common chemical reaction conditions, if the reaction conditions are mild, 5- (3-hydroxyethyl) -2-methylpyridine can maintain a relatively stable state. However, under extreme conditions such as strong acids, strong bases, or high temperatures, its structure may change. For example, strong acids may protonate nitrogen atoms on the pyridine ring, and strong bases may initiate some reactions of hydroxyethyl groups. But in normal storage and general chemical reaction environments, it has certain stability and can maintain its own structure and chemical properties.

To prepare 5- (3-thiophenyl) - 2-methylpyridine, the synthesis method is as follows:
###Route using thiophene and pyridine derivatives as raw materials
1. ** The first step: functionalization of thiophene **
Take an appropriate amount of thiophene, add a suitable halogenating reagent, such as N-bromosuccinimide (NBS), and use carbon tetrachloride as a solvent. Under the action of light or initiator, the 3-position of thiophene is halogenated to generate 3-halogenated thiophene. This reaction requires strict control of the reaction temperature and the amount of reagents to prevent the formation of polyhalogenated by-products. < Br > 2. ** Second step: Preparation of pyridine derivatives **
Using 2-methylpyridine as the starting material, in the presence of an appropriate base (such as potassium tert-butanol), react with a suitable electrophilic reagent to introduce a suitable functional group on the pyridine ring in preparation for the subsequent coupling reaction. For example, a borate ester group or a halogen atom can be introduced.
3. ** The third step: coupling reaction **
The obtained 3-halothiophene and the modified 2-methylpyridine derivative are coupled in an organic solvent (such as a mixed solvent of dioxane and water) under the action of a palladium catalyst (such as tetra (triphenylphosphine) palladium (0)). This reaction condition needs to be precisely controlled, and factors such as temperature, catalyst dosage and reaction time have a great influence on the reaction yield. After this reaction, the target product 5- (3-thiophenyl) -2-methylpyridine can be obtained.
###Route for constructing thiophene and pyridine rings from other raw materials
1. ** Selection and reaction of starting materials **
Select alkynes and nitriles containing suitable substituents. First, the cyclization reaction between alkynes and nitriles occurs under the action of specific catalysts (such as transition metal catalysts) to construct the basic skeleton of the pyridine ring. In this process, the 2-position methyl group of the pyridine ring can be introduced by adjusting the structure and reaction conditions of the substituents.
2. On the basis of the constructed pyridine derivatives, thiophene rings are constructed by intramolecular cyclization reaction using suitable sulfur-containing reagents and reaction conditions. For example, using sulfur-containing enol ether compounds, under acid catalysis, nucleophilic addition-cyclization reaction occurs with pyridine derivatives to generate the target product 5- (3-thiophenyl) -2-methylpyridine. Although this route is relatively complicated, the raw materials are widely sourced, which provides another idea for synthesis.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the appropriate synthesis route should be selected according to the comprehensive consideration of various factors such as the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the target product.

There is now a product name "5- (3-hydroxypropyl) -2-methylpyridine", and I would like to know how its price is in the market.
Looking at the transactions in the market, the price of various things often varies depending on the quality, quantity, time, place and supply and demand. This "5- (3-hydroxypropyl) -2-methylpyridine", if the quality is high and the quantity is sufficient, the price may be high when the demand is high and suitable; on the contrary, if the quality is low, the price may be low when the demand is light or partial.
However, I have not seen this "5 - (3 - hydroxypropyl) - 2 - methylpyridine" in the market, nor do I know the current supply and demand situation, so it is difficult to determine its price. Or you can visit various pharmaceutical shops and chemical markets, and ask those who sell this product, or you can get a more accurate price. Or search its price on the market website, and you can get an approximate number. However, no matter what method, you must carefully check its quality and quantity, as well as the various conditions of the transaction, before you can get a fair price.