4 Trifluoromethyl Pyridine 3 Carboxamide
pyridine pyrrole pyrazine piperidine piperazine

4-(trifluoromethyl)pyridine-3-carboxamide

    Specifications

    HS Code

    441770

    Chemical Formula C7H5F3N2O
    Molar Mass 190.122 g/mol
    Appearance Solid (likely white or off - white powder)
    Melting Point N/A (need to check experimental data)
    Boiling Point N/A (need to check experimental data)
    Solubility In Water Low solubility (due to non - polar fluoromethyl group)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Density N/A (need to check experimental data)
    Pka N/A (for the amide group, need experimental determination)
    Flash Point N/A (need to check experimental data)

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    Frequently Asked Questions

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    What are the chemical properties of 4- (trifluoromethyl) pyridine-3-formamide?
    The chemical properties of (trimethylmethyl) to its (trimethylbenzyl amine) are generally special. This compound, whose molecules contain the combination of specific atoms, results in the chemical specialization.
    First, it has a certain degree of chemical properties. The chemical properties of different atoms are different, and the chemical properties of benzyl methyl groups in trimethylbenzyl amines make the chemical molecules uneven and generate chemical properties. This property makes it soluble in the chemical solution, and the chemical molecules can attract each other by the chemical action.
    Furthermore, it has the activity of nuclear or chemical. The benzene in the benzyl part has the characteristics of rich molecules, and can be used for nuclear substitution and other reactions. For example, it can be attacked to make benzene be substituted. The methyl part is stable in phase, but under certain conditions, such as oxidation or high temperature, it may also generate reaction, and its alpha-reaction can be activated. It is also worth noting that
    and its acidic properties are also worth noting. There are solitary ions on the nitrogen atom of trimethylbenzylamine, which can accept ions and show weak properties. In an acidic environment, it can be combined to form atoms. This property makes it specific in the acid reaction system, and can be used in separation, extraction, and other operations.
    And because its molecules contain aromatic alkyl groups, it has certain qualitative properties. The combination of aromatics and aromatics makes the molecule able to resist the attack of partial normalization, and the alkyl group and alkyl group also provide a certain degree of stability. However, in the case of strong components such as oxidation and acid, it will still cause biochemical reactions, resulting in molecular modification.
    Therefore, the chemistry of (trimethyl) to its (trimethylbenzylamine), determined by its molecules, is of great significance in the fields of synthesis and chemical analysis under different chemical environments.
    What are the physical properties of 4- (trifluoromethyl) pyridine-3-formamide?
    Triethylamine is an organic compound. It is a colorless to light yellow transparent liquid, has ammonia odor, is alkaline, and can be miscible with water, alcohols and ethers. Its physical properties are many, as detailed below:
    - ** Boiling point **: about 89.5 ° C. At this temperature, triethylamine changes from liquid to gaseous state, and can be separated from the mixture by distillation.
    - ** Melting point **: about -114.8 ° C. When the temperature drops below the melting point, triethylamine solidifies from liquid to solid.
    - ** Density **: about 0.726 g/cm ³, lighter than water, so when mixed with water, it floats on water. < Br > - ** Solubility **: Soluble in water, the lid can form hydrogen bonds with water because of its alkalinity, and can be miscible with a variety of organic solvents such as ethanol, ether, etc. This property makes it often a good solvent in organic synthesis.
    - ** Odor and Appearance **: Colorless to light yellow transparent liquid with a strong ammonia-like odor. Its odor is pungent, and it should be ventilated during operation to prevent discomfort.
    3-ethylpyridine is a derivative of pyridine. It is also a liquid and has the following physical properties:
    - ** Boiling point **: about 194 - 195 ° C, higher boiling point, due to complex intermolecular forces, including hydrogen bonds, van der Waals forces, etc., causing it to require a higher temperature to vaporize.
    - ** Melting point **: about -60 ° C, cooled to below the melting point, the substance changes from liquid to solid state.
    - ** Density **: about 0.981 g/cm ³, slightly heavier than water.
    - ** Solubility **: Soluble in water and also miscible with a variety of organic solvents. Due to its molecular structure containing nitrogen atoms, it has a certain polarity, which is conducive to dissolving with polar solvents such as water and some organic solvents.
    - ** Odor and Appearance **: Usually colorless to light yellow liquid, or with a special pyridine odor.
    These two have their own physical properties and have their own uses in organic chemistry, pharmaceuticals and chemical industries, or as solvents, or as synthetic raw materials, depending on their unique physical properties.
    What is the synthesis method of 4- (trifluoromethyl) pyridine-3-formamide?
    To prepare 4- (triethylmethyl) pentyl-3-enonitrile, you can do it according to the following method.
    First take the appropriate halogenated hydrocarbons, such as the halogenated compounds containing the triethylmethyl structure, and the carbon connected to the halogen atom needs to have the appropriate activity for the subsequent reaction. In addition, nucleophiles containing cyanide groups are commonly used, such as sodium cyanide (NaCN) or potassium cyanide (KCN).
    In a suitable solvent, such as dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF), such solvents have good solubility and promotion of nucleophilic substitution reactions. Mix the halogenated hydrocarbons with nucleophilic reagents to control the reaction temperature. Generally speaking, moderate heating, between about 50 and 80 degrees Celsius, can accelerate the reaction process. The cyanoanion (CN) in the nucleophilic reagent, because of its strong nucleophilicity, will attack the carbon attached to the halogen atom in the halogenated hydrocarbon, the halogen atom leaves, and a nucleophilic substitution reaction occurs, resulting in the target product 4- (triethylmethyl) pentyl-3-enonitrile.
    In addition, alkenyl halide can also be used with triethylmethyl-containing metal-organic reagents, such as Grignard reagent or lithium reagent, to first metallize to form a carbon-metal bond. Afterwards, it reacts with a cyanide source, such as cuprous cyanide (CuCN). This reaction is carried out at low temperature to room temperature in an anhydrous and oxygen-free inert gas protective atmosphere. The metal-organic reagent reacts with the alkenyl halide for metal exchange or nucleophilic addition, and then interacts with the cyanide source to generate 4- (triethyl) pentyl-3-enonitrile. During operation, it must be noted that the metal-organic reagent is extremely sensitive to water and air, and the reaction system must be kept dry and oxygen-free.
    In addition, the nucleophilic substitution reaction of the nucleophilic substitution reaction can be designed to construct the target molecular skeleton with compounds containing ethylene bonds and suitable leaving groups and nucleophilic reagents substituted with triethylmethyl groups, and then the cyano group is introduced by appropriate means. For example, the nucleophilic reagent is used to replace the leaving group to form the intermediate product, and then the intermediate product is reacted with a suitable cyanide reagent to achieve the introduction of the cyanide group, and finally synthesize 4- (triethyl) pentyl-3-enonitrile. The whole process requires fine regulation of the reaction conditions, including the amount of reagent, reaction temperature, reaction time, etc., to ensure high yield and purity.
    In which fields is 4- (trifluoromethyl) pyridine-3-formamide used?
    (Sanxiangmethyl) alkane and trimethylborane, both of which have applications in many fields.
    In the field of organic synthesis, (sanxiangmethyl) alkane is often used as an important intermediate. Due to its special structure, it can participate in many key chemical reactions and help build complex organic molecular structures. For example, under specific catalytic conditions, it can undergo an addition reaction with compounds containing unsaturated bonds, realizing the growth of carbon chains and the introduction of functional groups, laying the foundation for the synthesis of new drugs, natural products and functional materials.
    Trimethylborane is widely used in the field of materials science. It can be used as a raw material for chemical vapor deposition processes. By controlling the reaction conditions, boron-containing films can be deposited on the surface of substrates. Such films have unique electrical, optical and mechanical properties, which are useful in semiconductor manufacturing, optical coatings, etc. For example, in the preparation of high-performance electronic devices, boron-containing films can optimize the conductivity and stability of the device.
    In addition, in the field of chemical production, (Sanxiangmethyl) alkane and trimethylborane also have their value. (Sanxiangmethyl) alkane can be used as a special solvent to regulate the reaction rate and selectivity by virtue of its solubility and effect on the reaction system. Trimethylborane can be used to prepare some special boron compounds, which are widely used in the production of catalysts, flame retardants and other products.
    In summary, (Sanxiang methyl) alkanes and trimethyl boranes have shown important application value in many fields such as organic synthesis, materials science, and chemical production, promoting the development and progress of related fields.
    What is the market outlook for 4- (trifluoromethyl) pyridine-3-formamide?
    Today, the world is flat, business is booming, and the market prospect of Sanxiang methyl ester and trimethylphthalic anhydride is also quite promising.
    View Sanxiang methyl ester, which has a wide range of uses and is involved in various fields of chemical industry. For example, in the paint industry, Sanxiang methyl ester can add luster to the paint, making it brighter in color and better in adhesion. It can make the paint firmly adhere to the surface of the object and last for a long time. In the field of ink, it can optimize the leveling of the ink, making the printed pattern and text clearer and more exquisite. Furthermore, in the adhesive industry, Sanxiang methyl ester can enhance the stickiness and flexibility of the adhesive, making the adhesive more stable and less prone to brittle cracking. Nowadays, with the vigorous development of construction, packaging and other industries, the demand for coatings, inks, and adhesives is increasing, and the Sanxiang methyl ester market has also expanded. The prospect is like the flowers of spring, and it is more and more gorgeous.
    And trimethylphthalic anhydride is not in the pool. In the field of synthetic resins, trimethylphthalic anhydride is one of the key raw materials. The synthetic resin has excellent performance and is widely used in insulating materials for electronic appliances, escorting the stable operation of electronic equipment. In the field of pharmaceutical intermediates, it plays an indispensable role in the synthesis of many drugs, which is related to people's livelihood and health. At present, the electronics industry is changing with each passing day, and the pharmaceutical industry is also constantly improving. The demand for trimethylphthalic anhydride is on the rise, just like a boat on the water, with a bright future
    However, the market is changing, and there are also challenges. Raw material price fluctuations, such as waves on the river, affect its production costs and profit margins. Peer competition is fierce, just like a hundred competing, and it is necessary to continuously improve product quality and service in order to stand out. However, overall, Sanxiang methyl ester and triphthalic anhydride have taken advantage of the east wind of the development of the times, and the market prospect is smooth. If we can seize the opportunity and meet the challenges, we will be able to ride the wind and waves in the business sea and achieve great results.