4 Trifluoromethyl Pyridine 2 Carbonitrile
pyridine pyrrole pyrazine piperidine piperazine

4-(Trifluoromethyl)pyridine-2-carbonitrile

    Specifications

    HS Code

    384626

    Chemical Formula C7H3F3N2
    Molar Mass 170.11 g/mol
    Appearance Solid (usually white or off - white)
    Boiling Point Data may vary, around 220 - 230°C under normal pressure
    Melting Point 75 - 78°C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Density Data may vary, approximate density around 1.3 - 1.4 g/cm³
    Refractive Index Data may vary depending on measurement conditions

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    General Information
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    Frequently Asked Questions

    As a leading 4-(Trifluoromethyl)pyridine-2-carbonitrile supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4- (trifluoromethyl) pyridine-2-carboxonitrile?
    Trimethyl ether, this thing is a wonder. Its main uses are probably two.
    One of them is used in the Tao. Those in ancient times have explored the properties of things in order to cure diseases and save people. Trimethyl ether has a peculiar effect, which can cure people's blood and clear the body. In case of chronic diseases, those who are ineffective, if they are used, they may have a miraculous effect. Such as suffering from cold disease, limb pain, with trimethyl ether in combination with other substances, can remove cold and remove the cold, and make the patient feel pain, and do stool. Another example is the blood-soaked person, who is sluggish and has a withered face. With trimethyl ether, it can benefit blood, revive the spirit, and be healthy.
    Second, it is used for the elixir. Taoist elixir, seeking to give birth to the elixir of immortality. Trimethylether can be used as the elixir material because of its special nature. Adding the elixir, adding the right amount can change the elixir's nature and make its effect better. The elixir, using this material to make the elixir, or it can prolong the life and benefit, and it may not be able to become a true immortal, but it is also expected to extend the elixir and improve the body's ability.
    Of course, trimethylether has its important use in the field of elixir, but its use also needs to be careful, and the appropriate amount and appropriate method can be used to achieve its effect.
    What are the synthesis methods of 4- (trifluoromethyl) pyridine-2-formonitrile?
    To prepare tetra- (triethylmethyl) -2-ethylnaphthalene, there are three methods.
    First, nucleophilic substitution with triethylmethyl halogen and 2-ethylnaphthalene under alkali catalysis. Active halogenated hydrocarbons, such as triethylmethyl iodine, are selected with potassium carbonate in acetonitrile solvent, heated and refluxed, the carbon-halogen bond in the halogenated hydrocarbon is isoclast, the halogen atom leaves, the triethylmethyl positive ion is formed, and the 2-ethylnaphthalene is electron-rich. The naphthalene ring is affected by the ethyl power supply, the electron cloud density increases, and the nucleophilic attack triethylmethyl positive ion forms a carbon-carbon bond. This process requires controlling the reaction temperature and time to prevent side reactions, such as hydrolysis of halogenated hydrocarbons or self-polymerization of 2-ethylene naphthalene.
    Second, the Grignard reagent method is used. First, triethylmethyl magnesium halide is prepared. Magnesium chips are reacted with triethylmethyl halide in anhydrous ether. Magnesium is inserted into the carbon-halide bond to form Grignard's reagent. Its carbon-magnesium bond has strong polarity and strong nucleophilicity. 2-Ethylnaphthalene reacts with triethylmethyl magnesium halide. Triethylmethyl negative ions in Grignard's reagent attack 2-ethylnaphthalene and then hydrolyze to obtain the product. The operation must be anhydrous and oxygen-
    Third, the alkylation reaction of Fu-g is used. Triethylmethyl chloride or triethylmethyl bromide is used as the alkylation reagent, anhydrous aluminum trichloride is used as the catalyst, and 2-ethylnaphthalene is used as the substrate. The catalyst polarizes the carbon-halogen bond in the halogenated hydrocarbon to form triethylmethyl positive ions, and attacks the 2-ethylnaphthalene naphthalene ring to obtain the target product. The reactivity is high, and attention should be paid to the regioselectivity. The naphthalene ring has α and β positions. Ethyl increases the electron cloud density of the α position of the naphthalene ring, and the alkylation mainly occurs at the α position. At the same time, the amount of catalyst and the reaction conditions are controlled.
    What are the physical properties of 4- (trifluoromethyl) pyridine-2-formonitrile
    (Trimethylmethyl) to the other methyl ether is a complex compound, and its physical properties are very specific.
    The outer layer is often a transparent liquid, and the smell has a special smell. The smell is not strong, but it is also distinguishable. Under normal conditions, its boiling phase is not high, and it is in a specific layer, which makes it easy to melt under certain conditions. Its density is slightly low in water, so if the water is mixed, it can float on the water surface, and the two are distinct and immiscible.
    Furthermore, (trimethylmethyl) to the other methyl ether has good performance. It can be observed in an open container for a short period of time. Its solubility is also special, soluble in many kinds of water, such as ethanol, ether, etc. This property makes it useful in many fields such as synthesis.
    Its viscosity is low, its fluidity is good, it flows in pipes or containers, and the resistance is small, so it can flow. In addition, the durability and durability of this compound are not very prominent, and it is a rare material. In some cases, it may be useful in some fields that require isolation and fusion.
    What are the chemical properties of 4- (trifluoromethyl) pyridine-2-formonitrile
    (Sanxiangmethyl) alkyne and dimethylarsine are both organic chemicals with their own chemical properties.
    (Sanxiangmethyl) alkyne, this substance has certain activity. Due to the existence of alkynyl groups, it can participate in many addition reactions. For example, with halogen elements, electrophilic addition can occur, and halogen atoms are successively added to the unsaturated bonds of alkynyl groups to form halogen-containing organic compounds. This reaction is often used in organic synthesis to introduce halogen atoms to prepare organic molecules with special structures. Addition can also occur with hydrogen halides. Following the Markov rule, hydrogen atoms tend to be added to unsaturated carbon atoms containing more hydrogen, so that halogenated olefins with different substitution modes can be constructed. In addition, (Sanxiangmethyl) alkyne can also carry out some metal-catalyzed reactions, such as coupling reactions with other alkynes or alkenyl compounds under the action of specific metal catalysts, which helps to build more complex carbon chain structures and has potential applications in the fields of materials chemistry and medicinal chemistry.
    And dimethyl arsine, arsenic atoms are connected with two methyl groups. Its chemical properties are affected by the characteristics of arsenic. Dimethyl arsine has a certain degree of reduction. Under the action of appropriate oxidizing agents, the valence state of arsenic atoms can be increased, and an oxidation reaction occurs to form compounds containing higher valence arsenic. At the same time, due to the electronic structure of the outer layer of arsenic atoms, dimethylarsine can be used as a ligand to form complexes with some metal ions, which has certain research value in coordination chemistry. However, it should be noted that arsenic-containing compounds are many toxic, and when studying and using dimethylarsine, extra caution should be taken to avoid harm to the environment and human body.
    What is the price of 4- (trifluoromethyl) pyridine-2-formonitrile in the market?
    Wen Jun inquired about the price of triethylamine and acetamide in the market. However, the market price of the two is not constant, but changes for many reasons.
    First, the amount of production and the amount of demand have a great impact on the price. If there are many of these two at a certain time, and there are few people who want them, the price will drop; conversely, if there are few producers and many people want them, the price will rise.
    Second, the price of raw materials is also the key. The production of triethylamine and acetamide requires all kinds of raw materials, and the fluctuation of the price of raw materials will lead to changes in the price of finished products. If the price of raw materials is high, the cost of making both will increase, and the price will also increase.
    Third, the art of making is also related to the price. If the new art is produced, the production efficiency can be increased and the cost reduced, and the price may drop; on the contrary, if the art is old, the production efficiency is low and the cost is high, the price will be difficult to drop.
    Fourth, the rules of the city also play a role. In the big market, there are many competitors, and the price may be more reasonable; in the small market, there are few competitors, and the price may be different.
    As for the current price of the two in the market, it is difficult to say for sure. If you want to know the details, you can visit the cities of chemical materials, or inquire about the merchants of chemical materials, and they will surely be able to tell you the price in the near future.