4-(pyrrolidin-1-yl)pyridine

4- (pyrrolidine-1-yl) pyridine, which has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of many drugs. The special structure of genopyridine and pyrrolidine gives the compound unique biological activity and pharmacological properties. Taking an antiarrhythmic drug as an example, 4- (pyrrolidine-1-yl) pyridine participates in the construction of the core structure, which helps the drug to precisely act on the cardiac ion channel, regulate the heart rhythm, and achieve therapeutic effect.
In the field of materials science, it also has important applications. It can be used as a raw material for organic synthesis materials, and materials with special photoelectric properties can be prepared through specific reactions. For example, when used in organic Light Emitting Diodes (OLEDs), with its structural characteristics, the luminous efficiency and stability of the material are optimized, making the display screen clearer and more colorful.
In the field of catalysis, 4- (pyrrolidine-1-yl) pyridine is often used as a ligand to coordinate with metal ions to form a catalyst. Because of its structure, nitrogen atoms can provide electron pairs to enhance catalyst activity and selectivity. In some organic synthesis reactions, the catalyst can efficiently catalyze reactions, improve product yield and purity, reduce production costs, and is of great significance in chemical production.

4- (pyrrolidine-1-yl) pyridine, this is an organic compound. Its physical properties are quite important, let me tell you in detail.
First of all, its appearance, under room temperature and pressure, 4- (pyrrolidine-1-yl) pyridine is mostly colorless to light yellow liquid, clear and with a certain degree of fluidity. Looking at it, it is like a clear oily liquid, flickering slightly under the light, which seems to hold endless mysteries.
As for its melting point, due to the characteristics of molecular structure, the melting point of this substance is low, usually hovering around -20 ° C. This melting point property allows it to remain liquid in a relatively low temperature environment and is not easy to solidify.
In terms of boiling point, it is about 260 ° C. A higher boiling point indicates that the intermolecular force is strong, and more energy is required to transform it from liquid to gaseous. This property is crucial in the process of separation and purification. It can be precisely separated from the mixture by distillation according to the difference in boiling point.
Solubility is also a key property. 4- (pyrrolidine-1-yl) pyridine is soluble in many organic solvents, such as ethanol, ether, chloroform, etc. This is because its molecular structure contains both the aromatic part of the pyridine ring and the pro-organic solvent part of the pyrrolidinyl group, so it can be well miscible with various organic solvents. However, its solubility in water is relatively limited, and it is only slightly soluble in water. This difference in solubility facilitates its application in chemical experiments and industrial production. According to different needs, suitable solvents can be selected for reaction, extraction and other operations.
In addition, the density of 4- (pyrrolidine-1-yl) pyridine is about 1.05 g/cm ³, which is slightly higher than that of water. This density characteristic can help determine its position in the mixed system in liquid-liquid separation and other operations. < Br >
Its flash point is about 110 ° C, which is an important indicator to measure its flammability. It shows that when approaching this temperature, in case of open flame or hot topic, 4- (pyrrolidine-1-yl) pyridine vapor can mix with air to form an explosive mixture, and there is a certain risk of fire and explosion. Therefore, during storage and use, it is necessary to strictly control the temperature and keep away from fire and heat sources to ensure safety.

To prepare 4- (pyrrolidine-1-yl) pyridine, there are many methods, each with its own advantages and disadvantages. The following are common synthesis paths.
First, pyridine is used as the starting material. Pyridine first reacts with an appropriate halogenation reagent to introduce a halogen atom, such as acting with a halogenating agent under suitable conditions to halogenate the pyridine ring at a specific position. Afterwards, the halogenated pyridine reacts with pyrrolidine in the presence of a base, which can help form pyrrolidine negative ions, and then undergoes nucleophilic substitution with halogenated pyridine to obtain the target product 4- (pyrrolidine-1-yl) pyridine. The raw material of this route is easy to obtain, but the halogenation step requires precise control of the reaction conditions to ensure the accurate positioning of halogen atoms. In the nucleophilic substitution reaction, the selection and dosage of bases have a great impact on the yield and purity of the reaction.
Second, start from the corresponding pyridine derivatives. If there are suitable pyridine derivatives containing active groups, they can be converted through multi-step reactions. For example, pyridine derivatives containing pyrrolidine substituents that can be converted into pyrrolidine substituents are constructed by condensation, cyclization and other reactions. This process may involve multi-step reactions, and the reaction sequence and conditions need to be carefully planned. Although the steps are complicated, they can be flexibly adjusted according to the characteristics of raw materials and reaction requirements, which may have advantages for the synthesis of target products with specific structures.
Third, with the help of transition metal catalysis. With suitable pyridine substrates and pyrrolidine derivatives as raw materials, a coupling reaction occurs under the action of transition metal catalysts. Transition metals can activate substrates and promote the formation of carbon-nitrogen bonds. This method has the characteristics of high efficiency and good selectivity. However, the cost of transition metal catalysts is high, and the reaction requires strict requirements on the purity of the reaction system and ligand selection. The operation needs to be fine to achieve the desired reaction effect. < Br >
When synthesizing 4- (pyrrolidine-1-yl) pyridine, no matter what method is selected, factors such as raw material cost, difficulty of reaction conditions, yield and product purity need to be considered. After optimizing the reaction parameters and conditions, satisfactory synthesis results can be obtained.

In today's world, the price of 4 - (pyrrolidin - 1 - yl) pyridine in the market is difficult to determine. This is because of many reasons involved, resulting in uncertain price fluctuations.
The first to bear the brunt is the trend of supply and demand. If there are many people who want this thing, but the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price will drop. If the market needs this for the prosperity of pharmaceutical and other industries, but there are few products, the price will be high; if there are many producers, the output is full, and the market accumulates this thing, the price will tend to be low.
Furthermore, the number of costs also affects its price. The price of raw materials, manufacturing costs, transportation costs, etc. are all key. Rare and hard to find raw materials, the price must be high, and the price of 4 - (pyrrolidin - 1 - yl) pyridine made in combination is also high; if the manufacturing method is complicated and laborious, the cost will increase and the price will also increase; if the transportation is long and dangerous, the price will also be affected by it.
The difference in origin also makes the price different. In different places, the price of output is also different due to the difference in resources and labor. And market competition is also the main reason. Competing with the industry, either to seize the market, or to reduce the price to attract customers, or to improve its quality and stabilize the price. < Br >
Therefore, in order to know the exact price of 4 - (pyrrolidin - 1 - yl) pyridine, it is necessary to check the supply and demand, cost, origin, competition, etc., and explore it in real time to obtain a more accurate price. However, it is difficult to determine the exact price range today.

4 - (pyrrolidine-1-yl) pyridine, there are many things to pay attention to when using this substance. The first thing to pay attention to is its chemical properties. This substance has specific reactivity and may react differently in different chemical environments. In case of strong oxidants, or cause violent oxidation reactions, it is necessary to avoid contact with strong oxidants when using, and store away from such substances to prevent accidents.
Furthermore, its physical properties should not be underestimated. The solubility, melting point, boiling point and other properties of 4 - (pyrrolidine-1-yl) pyridine all affect its use. For example, if you need to react in a solution, you must first know its solubility in different solvents and choose a suitable solvent to ensure the smooth progress of the reaction. And its melting point and boiling point are related to heating or cooling operations. If the operating temperature is improper, or the substance is volatilized and decomposed, it will affect the experimental results or production quality.
Safety is also a top priority. This substance may be toxic and irritating, and protective measures must be taken during operation. If you wear suitable protective gloves, goggles, and protective clothing to prevent skin contact and eye splashing. At the same time, the operation should be carried out in a well-ventilated place to avoid inhaling its volatile aerosols. If you inadvertently inhale, contact, or ingest it, you should take corresponding first aid measures and seek medical attention immediately.
In addition, it is crucial to control the reaction conditions during use. Such as temperature, pH, reaction time, etc., all have a great impact on the reaction process and product purity. If the temperature is too high or too low, or the reaction rate is abnormal, the product is impure; if the pH is not good, or the reaction cannot be carried out, or by-products are generated. Therefore, before the experiment or production, it is advisable to conduct a small test to explore the appropriate reaction conditions for the best effect.