4-pyridylamine

The reason why a person coughs is that the lungs feel the evil of cold. The lungs dominate the qi, waiting for the fur, and the evil fights in the qi, so it makes the cough. The main use of the cough is related to removing evil, promoting the lungs, and regulating the qi.
Cold pathogens bind the lungs, and the lung qi loses publicity, and the airway is unfavorable, and it occurs as a cough. Therefore, it is necessary to remove evil, in order to disperse the cold pathogens that are in the lungs. When the cold pathogens are gone, the lung qi can regain its smooth nature.
The lungs are the main propagating and lowering, and the action of promoting the lungs can stretch the suppressed lung qi, and the qi will disperse the body fluid, and the phlegm will also disappear. Such as ephedra, the nature is warm and refreshing, and it can open the wounds and dissipate the cold, so that the lung qi can be passed through, which is a commonly used medicine for cough.
And qi is the master of the lungs, and if the qi is smooth, it will stop the cough. When coughing, the lung qi is often disordered, and the method of regulating qi can make the lung qi smooth. Such as tangerine peel, the taste is hard and warm, and it has the power of regulating qi and strengthening the spleen, drying dampness and reducing phlegm, which can help the lung qi to fall smoothly.
And the lungs are delicate and intolerant to cold and heat, so the medication should be cautious. For those with cold cough, do not use cold products to avoid hurting the lung qi; for those with hot cough, do not use warm drugs to prevent heat and injury. < Br >
Therefore, the main use of cough, removing evil to remove the cause of disease, recuperating the lung to restore the function of the lung, and regulating qi to adjust the inverse of lung qi. The three complement each other and aim to return the function of the lung to normal, and the cough stops. When taking medication, carefully review the cause of the disease, cold, heat, and reality, in order to cure the disease.

Thunder is born from the thinness of yin and yang, and its nature is fierce and violent, containing the power to destroy the sky and destroy the earth.
Looking at its sound, thunder is startled, and the sound is like the roar of a bell, and it seems that ten thousand horses are galloping, rolling over, shaking the universe, making mountains and rivers tremble, and birds and beasts are terrified. This sound is transmitted between heaven and earth, and its speed can reach a hundred miles away in an instant, like a sharp blade penetrating the sky, frightening people.
As for thunder, it shines like the day, shining brightly. Its shape is like a winding flood dragon, dancing in the sky, tearing apart the night, and in an instant it shines the sky and the earth like day. And it carries high temperature and heat, and what is touched is instantly turned into powder, or charred.
The power of thunder should not be underestimated either. It contains a huge amount of electrical energy, which is not comparable to anything else in the world, and is extremely powerful. Between heaven and earth, it can smash boulders and break huge trees. When thunder falls, a powerful current is released, and wherever it passes, the air is heated and expanded rapidly, generating a violent shock wave, which is enough to overturn houses and destroy everything that is in their way.
Furthermore, thunder is often accompanied by wind and rain. When it comes, there is often a strong wind, and the torrential rain pours down. The wind helps thunder, and the rain adds thunder, making the power of thunder more diffuse and destructive. The wind, rain and thunder are intertwined, like the wrath of heaven and earth, warning all things in the world, showing the supreme majesty of nature. Therefore, the physical properties of thunder, shocking sound, lightning dazzling, energy and often coexist with wind and rain, its power is awe-inspiring, it is the irresistible power between heaven and earth.

Nitrate is also an important substance for gunpowder. Its chemical properties are quite unique.
Nitrate has strong oxidizing properties. In gunpowder, nitrate can co-ignite with carbon, sulfur and other substances, releasing a huge amount of gas and heat in an instant. Take black powder as an example. Nitrate is an oxidizing agent, which helps carbon and sulfur burn violently and turn into explosions and fireworks. This oxidizing property can make combustible substances oxidize violently in a short period of time, and it will be in a state of deflagration.
And nitrate is easily soluble in water. In water, nitrate can dissociate into ions and disperse among water molecules. This property allows it to be separated or mixed with other substances by water dissolution in some processes. For example, in pharmaceuticals and alchemy, water is often used as a medium to dissolve nitrate or purify nitrate.
Furthermore, the stability of nitrate also has its own characteristics. Under normal conditions, nitrate can be stable. In case of hot topics, open flames, or contact with specific things, it is easy to cause violent changes. In case of sulfur or carbon and reach the ignition point, it will explode. Therefore, when storing nitrate, it is necessary to avoid fire and heat to prevent its accidental change.
The crystal structure of nitrate also affects its properties. Its crystal has a regular shape and is stable in crystalline state. However, after grinding, heating and other treatments, the crystal structure may change, causing its chemical activity and reaction rate to be different.
The ancients' alchemy, pharmaceuticals, and gunpowder all knew the properties of nitrate. If used properly, it would become a sharp weapon and a wonderful medicine; if used carelessly, it would cause disaster. This is the general chemical nature of nitrate.

There are many synthesis methods of 4-oxime pentanoic acid, and the following are selected:
First, ethyl acetoacetate is used as the starting material, and the nitrosation reaction occurs with sodium nitrite in an acidic environment to obtain acetoacetyl nitrite. This intermediate product is then hydrolyzed to obtain 4-oxime pentanoic acid. This route is easy to obtain raw materials, and the reaction conditions are relatively mild, which is quite commonly used in laboratory synthesis. The key step is the precise control of the nitrosation reaction, which requires strict control of the reaction temperature and pH to improve the yield and purity of the target product.
Second, with 2-pentanone as the starting material, it can be directly reacted with hydroxylamine hydrochloride under the action of an alkaline catalyst to generate 4-oxime pentanoic acid in one step. The method has simple steps and high atomic economy. However, the selection and dosage of basic catalysts have a significant impact on the reaction process and need to be carefully optimized.
Third, 4-oxime valeric acid can also be synthesized with the help of biological enzyme catalysis. Some specific lipases, transaminases, etc. can efficiently catalyze the conversion of substrates into target products under mild reaction conditions. This method has outstanding advantages such as mild reaction conditions, high selectivity, and environmental friendliness. However, the preparation and purification of biological enzymes are complicated and costly, which limits their large-scale industrial application.
Fourth, glutaric acid anhydride is used as raw material, first glutaric acid monoester is obtained by reduction reaction, then reacts with hydroxylamine to form oxime, and finally hydrolyzes to obtain 4-oxime valeric acid. This route has relatively many steps, but the controllability of each step is good, and the overall yield can be improved by optimizing the reaction conditions of each step.
In actual synthesis, the most suitable synthesis method should be selected according to specific needs, considering factors such as raw material cost, reaction conditions, product purity and yield.

Those who use this kind of mixed essence fan should be aware of all things and must be cautious. This is an ancient artifact. If you are not careful, you will be afraid of disaster.
The first person to use the fan, you must first be sincere and clear of distractions. The artifact has a spirit, and only the sincerity can control it. If you have evil thoughts, greed, anger, and jealousy, the artifact will not be used, but there will be a risk of backlash. In the past, there were evil people who tried to use the fan to make a mistake, and if you hold the fan, you will feel a severe pain in the arm. If you are struck by lightning, it will heal in a few days. This is a sign that the artifact is self-guarding.
Second, when you use the fan, you should check the weather, time and place. The mixed yuan fan can attract the power of heaven and earth. If the weather is not suitable or the location is not appropriate, use it rashly, or cause the weather to be abnormal and the river to mutate. For example, in the midst of summer, if you fan it in a dry land, you want to descend, but due to the disorder of heaven and earth and the opportunity, the sand is made big, and the people do not talk about life. Therefore, in front of the fan, you must observe the sky carefully, be familiar with geography, and be able to make good use of its power.
Furthermore, after using the fan, it needs to be properly placed. This fan should not be discarded at will, but should be wrapped in pure brocade and hidden in a secret room. If it is left exposed to the outside, or coveted by others, it will cause disputes. And if the artifact is left unclean for a long time, it will also damage its spirit and weaken
If you use the Mixed Yuan Fan, you should not use it too often. Although the artifact is strong, the power of heaven and earth also has its limits. If you drive it frequently, not only will the artifact be vulnerable, but it will also destroy the balance of heaven and earth. If you use the fan for years to ask for money, although it will benefit you for a while, it will cause severe drought in your neighbors. This is the harm of excessive use.
In short, although the Mixed Yuan Fan is a divine object, the user must be in awe and strictly abide by the taboos, so as to use it without harming yourself and the world.