4-Pyridinecarboxylicacid,2-cyano-,hydrazide

This is a question about the chemical structure of "4-pyridinecarboxylic acid, 2-cyano-, hydrazide". To clarify the details, it should be explained by chemistry.
The name of this compound already contains many structural clues. "4-pyridinecarboxylic acid" shows that the fourth position of the pyridine ring is connected with a formate group. Pyridine is a nitrogen-containing hexaadic ring and has aromatic properties. "2-cyano" shows that the second position of the pyridine ring is connected with a cyano group (-CN), which is a functional group of carbon-nitrogen triple bonds. " Hydrazide "is a functional group formed by the condensation of carboxylic acid and hydrazine ($H_2N - NH_2 $), which is the condensation of pyridinecarboxylic acid and hydrazine.
Its chemical structure is roughly as follows: with the pyridine ring as the core, the 4-position of the ring is connected to the formic acid group (the hydrazide structure after the condensation of $-COOH $with hydrazine, or $-CONH - NH_2 $), and the 2-position cyanide of the ring ($-CN $). In this way, the chemical structure outline of" 4-pyridinecarboxylic acid, 2-cyano-, hydrazide "is outlined.

4-Pyridinecarboxylic acid, 2-cyano-, hydrazide, its physical properties are as follows. This substance is either solid at room temperature, or white to off-white powder, with a fine texture and a frost-like snow.
When it comes to the melting point, it is about a certain temperature range. This temperature is the critical point for its conversion from solid to liquid, which is crucial for the identification and purification of this substance. Its solubility in water is limited, but it can exhibit good solubility in some organic solvents, such as some polar organic solvents. This is related to many factors such as the polarity of the solvent and the intermolecular forces. < Br >
Its density is also a specific value, reflecting the quality of the substance per unit volume. This physical quantity plays an indispensable role in many chemical processes and product designs. And the stability of this substance is acceptable. Under the conventional temperature and humidity environment, it can maintain the relative stability of its chemical structure and properties. In case of extreme chemical environments such as strong acids and alkalis, it may trigger chemical reactions, causing its structure and properties to change. In addition, the smell of this substance is weak, close to the smell, you can feel a little special smell, but the impact of this smell on the human body is not yet clear, and careful protection is still required when using it.

4-Pyridinecarboxylic acid, 2-cyano-hydrazide, that is, 2-cyanopyridine-4-formylhydrazide, is widely used.
In the field of medicinal chemistry, it is often the key raw material for the creation of new drugs. Due to its structural properties, it can be combined with specific targets in organisms. For example, when developing antibacterial drugs, it can interact with key bacterial metabolic enzymes to interfere with the normal metabolic process of bacteria, thereby achieving antibacterial effect; in the development of anti-cancer drugs, it may act on specific signaling pathway proteins of cancer cells to inhibit the proliferation and spread of cancer cells.
In the field of materials science, 2-cyanopyridine-4-formylhydrazide can be used to prepare materials with unique functions. For example, introducing it into polymer materials can endow materials with special optical or electrical properties. Due to the heteroatoms contained in its molecular structure, such as nitrogen and oxygen, it can change the electron cloud distribution of the material, making the material have unique photoelectric response characteristics, or it can be applied to organic Light Emitting Diodes, sensors and other devices.
In the field of organic synthesis, it is an extremely important class of intermediates. Because it contains highly active cyano and hydrazine groups, it can participate in a variety of organic reactions. Such as condensation reaction with aldehyde and ketone to generate nitrogen-containing heterocyclic compounds with diverse structures, providing an effective way for the synthesis of complex organic molecules, greatly enriching the types and structures of organic compounds, and promoting the further development of organic synthetic chemistry.

To prepare 4-pyridine carboxylic acid, 2-cyano-hydrazide, there are various methods. One common way is to start from the pyridine. First take the pyridine as the group, and introduce the cyano group at its 2 position by an appropriate method, or by means of nucleophilic substitution, select the appropriate cyanide reagent, and control the reaction conditions, such as temperature, solvent, catalyst, etc., so that the cyano group can be stabilized at the 2 position of the pyridine ring.
Then, the change of hydrazide at the 4-carboxylic group is performed. 4-Pyridinecarboxylic acid can be first converted into its active derivatives, such as acid chloride, and reagents such as thionyl chloride can react with it to obtain 4-pyridinecarboxylic chloride. Then the acid chloride meets the hydrazine reagent, and in a suitable environment, such as neutral or weakly basic medium, it undergoes acylation reaction to obtain 4-pyridinecarboxylic acid, 2-cyano-hydrazide.
Or another way, starting from the raw materials containing cyanyl groups and pyridine rings, the pyridine ring structure is first constructed. During the construction process of the ring, the cyano group and the 4-position group that can be derived into the carboxyl group are carefully arranged. After pyridine cyclization, the 4-position group is gradually converted into a carboxyl group, and then the hydrazide reaction is carried out.
During the reaction, the choice of solvent is very important, such as the aprotic polar solvent dimethylformamide, dimethyl sulfoxide, etc., which often helps to carry out nucleophilic substitution and other reactions. The control of temperature is related to the selectivity of the reaction rate and product, or the low temperature slows the reaction to avoid side reactions; or the high temperature promotes the reaction to accelerate and achieve the expected transformation. The addition of catalysts can also change the process of the chemical reaction and make the reaction smoother. In short, in order to form this substance, all conditions need to be carefully adjusted to obtain satisfactory results.

4-Pyridinecarboxylic acid, 2-cyano-, hydrazide, when storing and using, many things should be paid attention to.
First word storage. Due to its nature, it should be placed in a cool, dry and well-ventilated place. If it is in a humid environment, or causes moisture and deterioration, it will affect its chemical properties. And it should be kept away from fire and heat sources, because it may be flammable or react with heat. In addition, it needs to be stored separately from oxidants, acids, bases, etc., to prevent chemical reactions caused by interaction, damage to its quality, and even lead to accidents.
As for use. Users must be familiar with the chemical properties and safety data of this product first. When operating, protective gear is indispensable, such as wearing appropriate protective gloves, safety glasses, protective clothing and gas masks if necessary to avoid contact with the skin, eyes, and inhalation of dust. The operating environment should also be well ventilated to reduce the concentration of this substance in the air to avoid harm to the human body. During use, strictly follow the established procedures, do not use in excess, and do not let this substance escape into the environment. If there is any accidental spill, it should be properly handled according to the corresponding emergency measures to ensure the safety of the environment and people.