4-Pyridinecarboxylic acid, 2-chloro-3-fluoro-, methyl ester

The Chinese name of this compound (4 - Pyridinecarboxylic acid, 2 - chloro - 3 - fluoro -, methyl ester) is methyl 2 - chloro - 3 - fluoropyridine - 4 - formate.
The English name of this compound, "4 - Pyridinecarboxylic acid" is pyridine - 4 - formic acid, which is the mother of pyridine, and has a formic acid group at the 4th position. And "2 - chloro - 3 - fluoro -" means the introduction of chlorine atoms at the 2nd position and fluorine atoms at the 3rd position of pyridine. " Methyl ester "indicates that the compound is a methyl ester, that is, the methyl group on the formic acid group is replaced by a methoxy group.
Therefore, the parts of the compound are combined and named according to the compound, and its Chinese name is 2-chloro-3-fluoropyridine-4-methyl formate. This nomenclature follows that the substituents are listed first, and then the parent group and the source of the functionalization are indicated, so as to clearly represent the molecule of the compound.

Methyl 2-chloro-3-fluoro-4-pyridyl carboxylate is an organic compound. Its main uses are diverse.
In the field of medicine, it is often used as a key intermediate. In the process of drug development, with the help of its unique chemical structure, it can be transformed through specific reactions and integrated into drug molecules to give drugs the required pharmacological activity. For example, for specific disease targets, build active structures that fit them, help develop new therapeutic drugs, or optimize the performance of existing drugs, improve efficacy and reduce side effects.
In the field of pesticides, it also plays an important role. It can become the basic raw material for the synthesis of high-efficiency pesticides. Due to its structural characteristics, the synthesized pesticides may have unique insecticidal, bactericidal or herbicidal effects. By precisely designing the reaction and combining it with other chemical substances, pesticides with specific effects on specific crop diseases and pests can be developed to ensure the healthy growth of crops and improve yield and quality.
In the field of materials science, it also has potential uses. Its chemical properties may participate in the synthesis of certain materials, giving the material special properties. For example, in the preparation of new polymer materials, it is introduced as a functional monomer to improve the electrical, optical or mechanical properties of the material, providing the possibility for the development of new high-performance materials.
Furthermore, it is an important starting material or intermediate in the study of organic synthetic chemistry. Scientists use its structural characteristics to conduct research on various organic reactions, explore new synthesis methods and routes, expand the boundaries of organic chemistry knowledge, and provide ideas and methods for the synthesis of more complex organic compounds.

To prepare methyl 2-chloro-3-fluoro-4-pyridinecarboxylate, there are many methods, and each has its advantages and disadvantages, and it is necessary to choose according to the actual situation.
First, it can be obtained by esterification of 2-chloro-3-fluoro-4-pyridinecarboxylic acid and methanol under acid catalysis. In this process, sulfuric acid, p-toluenesulfonic acid, etc. are often used as catalysts. First, 2-chloro-3-fluoro-4-pyridinecarboxylic acid and methanol are placed in a reaction vessel in a certain proportion, an appropriate amount of catalyst is added, heated and stirred. When the reaction number is generally at 60-80 ° C, the reaction progress is monitored by thin-layer chromatography during this period. When the raw materials are exhausted and cooled, the reaction solution is neutralized to neutral in sodium bicarbonate solution, then extracted with an organic solvent, dried by anhydrous sodium sulfate, distilled under reduced pressure to remove the solvent, and obtained crude products. After column chromatography or recrystallization, the operation of this method is relatively simple, the raw materials are easy to obtain, but the reaction time is long, and the acid catalyst is corrosive to the equipment.
Second, 2-chloro-3-fluoro-4-pyridinoyl chloride is reacted with methanol. First prepare 2-chloro-3-fluoro-4-pyridinoyl chloride, usually react with thionyl chloride with 2-chloro-3-fluoro-4-pyridinoic acid, and then distill under reduced pressure to remove excess thionyl chloride when heated for a number of refluxes. Then slowly drop 2-chloro-3-fluoro-4-pyridinoyl chloride into a solution containing methanol and an acid binding agent (such as triethylamine) and react at a low temperature, such as 0-10 ° C. After the reaction is completed, the salt is filtered off, and the filtrate is distilled under reduced pressure. The crude product is purified to obtain the target product. This approach has a fast reaction rate and high yield. However, thionyl chloride is corrosive and irritating, so the operation needs to be cautious.
Third, it can be constructed by the corresponding pyridine derivatives through multi-step reaction. First, specific substituents are modified for the pyridine ring, chlorine and fluorine atoms are introduced, and then carboxyl methyl esterification is carried out. This process is complicated and requires precise control of the reaction conditions of each step. However, it may achieve good results for specific structural requirements.
When preparing methyl 2-chloro-3-fluoro-4-pyridine carboxylate, factors such as raw material cost, reaction conditions, equipment requirements, yield and purity need to be comprehensively considered to determine the best synthesis path.

4-Pyridinecarboxylic acid, 2-chloro-3-fluoro-, methyl ester, is one of the organic compounds. Its physical and chemical properties are particularly important, and it is related to the behavior of this compound in various situations.
In terms of its physical properties, this substance is either solid or liquid at room temperature, depending on the intermolecular forces and structural characteristics. If the intermolecular attractive forces are strong and arranged in an orderly manner, it tends to be solid; conversely, if the intermolecular forces are weak and the movement is relatively free, it is liquid. Its melting point and boiling point are also key indicators. The melting point can indicate the temperature of a substance from solid to liquid, and the boiling point indicates the temperature of liquid to gas. The two depend on the molecular weight, intermolecular forces and molecular structure. Generally speaking, the molecular weight is large, the intermolecular forces are strong, and the melting point and boiling point are high.
Looking at its chemical properties, it has a specific chemical reaction activity due to the presence of ester groups and pyridine rings. Ester groups can be hydrolyzed, and under acidic or basic conditions, they can interact with water to decompose into corresponding acids and alcohols. The nitrogen atom of the pyridine ring has lone pairs of electrons, which makes it alkaline, can form salts with acids, and can also participate in nucleophilic substitution reactions. And the presence of chlorine atoms and fluorine atoms, due to the characteristics of halogen atoms, can undergo reactions such as nucleophilic substitution, fluorine atoms have high electronegativity, or affect molecular polarity and reactivity, chlorine atoms are relatively easy to leave, so that molecules can undergo chemical transformations such as substitution under specific conditions.

I think what you are asking is about the price range of "4-pyridinecarboxylic acid, 2-chloro-3-fluoro-methyl ester" in the market. However, the price of this compound often varies due to multiple factors, so it is difficult to determine its specific price.
First, the difficulty of obtaining raw materials and the cost have a great impact on its price. If the raw materials required to produce this compound are scarce and rare, or the process of extraction and purification is complicated, the cost will increase, and then its market price will rise.
Second, the precision of the production process is also the key. < Br >
Third, the market supply and demand situation determines the price. If the demand is strong and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may decline.
Fourth, the sales channel and regional differences cannot be ignored. Different sales platforms and regions may have different pricing due to factors such as operating costs and market competition.
To sum up, in today's market, the price range of "4-pyridinecarboxylic acid, 2-chloro-3-fluoro-methyl ester" is difficult to generalize, ranging from tens of yuan per gram to hundreds of yuan. To determine its price, it is necessary to carefully check the market dynamics and consult relevant suppliers.