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4-Pyridinecarboxamide, what is the chemical structure of N-phenyl-
4 - Pyridinecarboxamide, N - phenyl - that is, N - phenyl - 4 - pyridinecarboxamide, its chemical structure is as follows:
The core structure of this compound is a pyridine ring, which is a six-membered aromatic heterocyclic ring containing a nitrogen atom. At position 4 of the pyridine ring, there is a formamide group (-CONH 2). In this group, the carbonyl group (C = O) is connected to the amino group (-NH 2), and the carbon atom of the carbonyl group is connected to the carbon at position 4 of the pyridine ring. On the nitrogen atom of the formamide group, a phenyl group (C H) is connected, and the phenyl group is the remaining part of the phenyl ring after removing a hydrogen atom. In this way, the chemical structure of N-phenyl-4-pyridineformamide is formed. The overall structure fuses the key parts of the pyridine ring, formamide group and phenyl group, and relies on the characteristics and interactions of these structural units to endow the compound with specific chemical and physical properties.
4-Pyridinecarboxamide, what are the physical properties of N-phenyl-
4-Pyridineformamide, N-phenyl - This substance has a number of physical properties. Its shape or crystalline state, when pure, the color is white and delicate. Its melting point is quite critical, about a specific temperature range, this property is of great significance when identifying and purifying.
When it comes to solubility, it has its unique performance in common organic solvents. In case of alcohol solvents, it can show a certain solubility, but in water, the degree of solubility is relatively limited. This difference in solubility is due to the characteristics of its molecular structure. The structural parts such as pyridine rings and phenyl groups contained affect the interaction with different solvent molecules.
Furthermore, its density is also an important physical property, and specific values can be obtained by precise measurement. This value reflects the mass per unit volume of the substance, and is indispensable in many practical application scenarios, such as chemical production, material ratio, etc.
In addition, 4-pyridineformamide, N-phenyl - also has a specific refractive index. This refractive index represents the refractive properties of light when passing through the substance, and is an important reference index in optical related research and quality inspection. By measuring its refractive index, it can assist in judging the purity of the substance and whether there are impurities.
4-Pyridinecarboxamide, what is the main use of N-phenyl-
4-Pyridineformamide, N-phenyl, has a wide range of uses. In the field of medicine, this substance can be used as a key raw material for the creation of new drugs. Physicians who want to find a cure for various diseases often rely on this substance as a base. After exquisite compatibility and complex refining, they can obtain a cure and save people.
In the field of material science, it also has important functions. Craftsmen want to make materials with special properties, such as unique adsorption and stability, 4-pyridineformamide, N-phenyl - can add unique properties to it, making the material suitable for multiple scenarios, such as adsorbing harmful gases to purify the environment, or enhancing the structural stability of materials.
Furthermore, it is an indispensable reagent in the road of scientific research and exploration. Bachelor's, PhD and other scientific researchers explore the mysteries of matter in the laboratory and analyze the reaction mechanism. They often use this material as a tool to use its characteristics to gain insight into the changes in the microscopic world, paving the way for scientific progress. It can also play a key role in the process of organic synthesis, helping to synthesize many organic compounds with complex structures and specific functions, and promoting the vigorous development of the field of organic chemistry.
4-Pyridinecarboxamide, what are the preparation methods of N-phenyl-
To prepare 4-pyridineformamide, N-phenyl-, there are various methods. One is to use 4-pyridineformamide chloride and aniline as materials, in a suitable reaction medium, such as organic solvents, common ones are dichloromethane, chloroform, etc., add an appropriate amount of acid binding agents, such as triethylamine, pyridine, etc., and the acylation reaction occurs. This reaction condition needs to be carefully controlled, and the temperature should not be too high. It is often maintained between low temperature and room temperature, about 0 ° C - 30 ° C, to ensure the smooth progress of the reaction and reduce side reactions. The reaction time depends on the monitoring of the reaction process, which can be tracked by thin-layer chromatography. When the raw material point is basically eliminated and the product point reaches the expected strength, the reaction is completed. After that, the product was purified by extraction, washing, drying, column chromatography and other means.
Second, 4-pyridinecarboxylic acid and aniline can be used as starting materials. First, 4-pyridinecarboxylic acid can be converted into active esters, such as with N, N-dicyclohexyl carbodiimide (DCC) and N-hydroxysuccinimide (NHS) to form active ester intermediates, and then react with aniline to form the target product. In this process, the formation of active esters needs to pay attention to the anhydrous and oxygen-free reaction environment to avoid side reactions. The subsequent reaction conditions are similar to the former, and the temperature and duration need to be controlled. The purification step is also indispensable to obtain high-purity 4-pyridineformamide, N-phenyl-.
Or through a specific catalytic reaction of pyridine and benzamide derivatives. Transition metal catalysts, such as complexes of palladium and copper, can be selected to promote the coupling reaction of the two in the presence of bases. This reaction requires strict catalyst activity, type and dosage of base. The reaction temperature is usually high, between 80 ° C and 120 ° C, and needs to be precisely adjusted according to the specific characteristics of the catalyst and the substrate. After the reaction, complex separation and purification steps are also required to obtain a purified product.
4-Pyridinecarboxamide, N-phenyl-what are the precautions during use
4-Pyridineformamide, N-Phenyl - When using this substance, many matters need to be paid attention to. First, it is related to safety. This substance may be toxic and irritating to a certain extent, and safety procedures must be strictly followed when operating. It is necessary to wear suitable protective equipment, such as gloves, goggles and protective clothing, to prevent it from contacting the skin, eyes and respiratory tract. After operation, the contact area should be properly cleaned.
Second, it is about storage. It needs to be stored in a cool, dry and well-ventilated place, away from fire, heat and oxidants. Due to its chemical properties, improper storage conditions or deterioration affect its performance and quality.
Third, it is related to the use specifications. Before use, it is necessary to read the relevant technical data and instructions carefully, and accurately grasp its characteristics, uses and operation methods. In the experiment or production process, strictly control the dosage and reaction conditions to avoid accidental reactions or reduce product quality.
Fourth, pay attention to environmental protection. Waste generated during use should be properly disposed of in accordance with relevant regulations, and must not be discarded at will to prevent pollution to the environment.
Fifth, transportation should not be ignored. During transportation, it is necessary to ensure that the packaging is intact, avoid vibration, collision and moisture, and prevent material leakage caused by package rupture. In conclusion, all aspects of the use of 4-pyridineformamide and N-phenyl should be treated with care to ensure safe, effective use, and a balance between environmental and human health.
