4-Pyridinecarboxaldehyde,2-fluoro-(9CI)

4-Pyridine formaldehyde, 2-fluoro- (9CI), is an organic compound. Its chemical properties are quite unique.
From a structural point of view, the pyridine ring is connected to an aldehyde group and a fluorine atom. The presence of aldehyde groups endows the compound with a certain degree of activity. The aldehyde group can participate in many chemical reactions, such as oxidation, which can be oxidized to carboxyl groups; it can also undergo reduction reactions to convert to alcohol hydroxyl groups. In the field of organic synthesis, aldehyde groups are often key functional groups and can be used to construct carbon-carbon bonds, such as through hydroxyaldehyde condensation reactions. The introduction of fluorine atoms greatly affects the properties of this compound. Fluorine atoms have strong electronegativity, which can change the distribution of molecular electron clouds, which in turn affects molecular polarity. This will affect its physical properties such as boiling point and solubility. In chemical reactions, due to the electron-withdrawing effect of fluorine atoms, the electron cloud density on the pyridine ring will decrease, which affects the activity and selectivity of the electrophilic substitution reaction on the ring. Relatively speaking, electrophilic substitution reactions are more likely to occur in positions with relatively high electron cloud density.
In addition, the pyridine ring itself is aromatic, has a certain stability, and also participates in a variety of reactions. Pyridine nitrogen atoms can provide lone pairs of electrons to form complexes with metal ions, which may have applications in catalysis and other fields. Due to the conjugate system of the pyridine ring, the compound may also exhibit special properties in terms of optical properties.

2-Fluoro-4-pyridyl formaldehyde (4-Pyridinecarboxaldehyde, 2-fluoro - (9CI)) is widely used in the field of chemical medicine.
In the process of organic synthesis, it is a key intermediate. It can be used to construct complex organic molecules through various chemical reactions. For example, with compounds containing active hydrogen, according to the condensation reaction method, products with specific functional groups can be generated. Such products may be used in drug development, materials science and many other aspects to develop their effectiveness.
In the field of pharmaceutical chemistry, it also plays an important role. Using it as a starting material, through multiple steps of exquisite synthesis, new drug molecules may be created. Due to the existence of pyridine and aldehyde groups, molecules are endowed with unique chemical and biological activities, or can be specifically combined with targets in organisms, thus exerting the effect of treating diseases.
In the field of materials science, through the reactions they participate in, materials with special properties can be prepared. Or affect the optical, electrical and other properties of materials, and contribute to the development of optoelectronic materials, polymer materials and other fields.
In the journey of scientific research and exploration, chemists use it as a basis to constantly try new reaction paths and new synthesis strategies, expand the boundaries of organic synthesis, and provide possibilities for innovative development in many fields. Its importance in the field of chemical medicine is just like the cornerstone in high-rise buildings, which is indispensable and leads the progress of scientific research and industry.

The synthesis method of 2-fluoropyridine-4-formaldehyde (4-Pyridinecarboxaldehyde, 2-fluoro- (9CI)) can follow the following steps.
First take the appropriate pyridine derivative as the starting material. The pyridine derivative needs to reserve a reactive group at a specific position for subsequent introduction of fluorine atoms and aldehyde groups. In the reaction system, carefully select suitable fluorination reagents, such as fluorinated active compounds, and this reagent should have the ability to selectively fluorinate at specific positions in the pyridine ring. Under appropriate reaction conditions, factors such as reaction temperature, reaction time and reaction solvent can cause the fluorinated reagent to undergo nucleophilic substitution or other suitable fluorination reactions with the pyridine derivative, so that fluorine atoms are successfully introduced into the 2-position of the pyridine ring to obtain fluorine-containing pyridine intermediates.
Next, for this fluorine-containing pyridine intermediate, select a suitable aldehyde-based reagent. Common aldehyde-based reagents can include specific organometallic reagents or other compounds with aldehyde-based functions. In a precisely regulated reaction environment, the aldehyde-based reagent reacts with the fluorine-containing pyridine intermediate, so that the aldehyde group is successfully connected to the 4-position of the pyridine ring. This process requires close attention to the reaction conditions to prevent side reactions from occurring and ensure the high efficiency and selectivity of aldehyde-based reactions.
After the reaction is completed, a variety of separation and purification methods, such as extraction, distillation, column chromatography, etc., are used to separate and purify the target product 2-fluoropyridine-4-formaldehyde from the reaction mixture system to obtain a high-purity product. The entire synthesis process requires fine control of the reaction conditions at each step and careful selection of reagents to effectively synthesize the target compound.

I haven't heard of the exact market price of 4-pyridyl formaldehyde, 2-fluoro- (9CI). The price of this chemical often varies depending on quality, purity, supply and demand, purchase quantity and seller. In the market, those with high purity and wide quantity may be expensive; if ordinary purity and quantity are small, the price may be slightly lower.
Looking at the price changes of chemical products in the past, if the raw materials are abundant and the craftsmanship is advanced, the price may drop; if the raw materials are scarce and the demand surges, the price may rise. However, if you want to know the current price of 4-pyridyl formaldehyde, 2-fluoro- (9CI), you must visit the chemical raw material supplier, chemical trading platform, or consult the person familiar with the price in the industry. They are able to give a price that is close to the truth according to the facts of the moment. Although it is difficult for me to state the exact price, by following this path, I can obtain an approximate price to help you plan things.

4-Pyridyl formaldehyde, 2-fluoro- (9CI) Many things need to be paid attention to during storage and transportation.
When storing it, it should be placed in a cool and dry place. Because of the cool and dry environment, it can be prevented from changing due to temperature and humidity discomfort. If it is placed in a warm and humid place, or it may cause chemical reactions to occur, its purity and quality will be damaged. And it should be stored separately from oxidizing agents, acids, bases and other substances. This is because the substance is chemically active and in contact with the above substances, it is easy to cause violent reactions or safety risks. The storage place should also be equipped with suitable containment leaking materials to prevent accidental leakage and dispose of them in time to avoid greater harm.
During transportation, do not take it lightly. Make sure that the container is well sealed to prevent leakage during transportation. Transportation vehicles need to be selected and equipped with corresponding safety protection equipment. Transportation personnel should be professionally trained and familiar with their hazard characteristics and emergency treatment methods. When transporting, they should also follow the specified route and stay away from dangerous places such as densely populated areas and fire sources. In this way, the storage and transportation of 4-pyridyl formaldehyde, 2-fluoro- (9CI) can be maximized to ensure safety and avoid accidents.