4 Pyridinecarbonitrile 2 Trifluoromethyl
pyridine pyrrole pyrazine piperidine piperazine

4-pyridinecarbonitrile, 2-(trifluoromethyl)-

    Specifications

    HS Code

    323017

    Chemical Formula C7H3F3N2
    Molecular Weight 172.11
    Appearance Solid (Typical)
    Solubility In Water Low (due to non - polar groups)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform

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    Frequently Asked Questions

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    What is the main use of 4-pyridylmethylnitrile, 2- (trifluoromethyl) -?
    The main use of this substance is in many fields such as medicine and chemical industry.
    In the field of medicine, it is an important raw material for the synthesis of traditional Chinese medicine. The preparation of many drugs depends on its participation in the reaction to form a specific chemical structure, which in turn imparts a specific pharmacological activity to the drug. For example, some antibacterial drugs with specific curative effects and drugs for the treatment of nervous system diseases, when synthesized, this compound is often a key intermediate, which has a significant impact on drug activity and efficacy.
    In the field of chemical industry, its use is also wide. First, it can be used as an organic solvent, because of its specific solubility and volatility, in the manufacture of coatings, inks, adhesives and other products, it can help the solute to disperse evenly, optimizing product performance and construction effect. Second, in the synthesis of polymer materials, it can be used as a reaction monomer or auxiliary, participating in the construction of polymer chains, affecting the properties of materials, such as hardness, flexibility, stability, etc.
    In addition, in the fragrance industry, because of its special chemical structure, it can be derived from unique aroma components, so it is also used to prepare specific fragrances to increase the richness and uniqueness of fragrances. In the cleaning process of the electronic industry, due to its good solubility and volatility, it can effectively remove oil and impurities from the surface of electronic components, ensuring the performance and reliability of electronic components.
    What are the physical properties of 4-pyridinecarbonitrile, 2- (trifluoromethyl) -
    The material properties of 4-amino-2- (triethylmethyl) - have the following characteristics:
    This material is usually solid in the outer layer, and its melting properties are characteristic. Due to the molecular action force, it can only be solidified at a certain degree. The value of this melting is very important to determine the solution. Its solubility is also important. In the solubility, due to the principle of similar miscibility, if the solubility matches its molecular properties, it has a certain solubility. In the non-soluble solution, the solubility is low due to the molecular force applied to overcome the attractive force of the soluble molecules.
    In terms of its chemical properties, the presence of amino groups makes this material have chemical properties, which can cause acid generation, neutralization and reaction, and form a phase. The distribution of molecular subclouds of triethylmethyl moiety has a shadow, so that the anti-molecular activity of molecular integration is very special. The local resistance effect of this group cannot be ignored. In the reaction, it may affect the ease of the reaction to approach the active center, and affect the reaction rate.
    In addition, the qualitative quality of the reaction is also a consideration factor. In the case of normal and specialized environmental conditions, it can maintain the stability of the phase. However, in case of special components such as high temperature, oxidation or original temperature, the molecular properties may be changed, induced and reversed, resulting in the transformation of the physical properties.
    Furthermore, the density of this substance is also one of its physical properties. This property depends on its molecular weight and the way of molecular stacking, which has certain significance for the distribution and mixing in different mediums. In addition, the polyphysics of 4-amino-2- (triethyl) are mutually dependent, and together determine their behavior in various chemical processes.
    What are the chemical properties of 4-pyridinecarbonitrile, 2- (trifluoromethyl) -?
    4-Alkylaniline, 2- (triethylalkyl) -this physical property is excellent, let me describe it.
    In this compound, the alkyl group of 4-alkylaniline, its carbon shortness, branching conditions, etc., all cause effects on the integrity. If the alkyl carbon is increased, the Vander force of the molecule increases, the melting boiling rate may increase, and the solubility in non-soluble solutions may also be improved. The aniline group, due to the solitary child on the nitrogen atom, has a certain degree of resistance to acid generation.
    The introduction of 2 - (triethylalkyl) adds more. Triethylalkyl and large substituents have a certain space resistance effect. This dislocation may affect the reactivity and space of the molecule. In terms of the reactivity of the molecule, the dislocation of the dislocation may lead to changes in the degree of reactivity such as nuclear substitution and dislocation. If the nucleus is intended to attack an active site in the molecule, the dislocation of the triethylalkyl group may form a barrier, which reduces the reversal rate.
    Furthermore, from a physical perspective, the presence of triethylalkyl groups may affect the reactivity of the molecule. Its phase is large, which makes the distribution of the molecule biological and affects its solubility in different dissolution. In some cases, the hydrophobicity of the triethylalkyl group may make the whole compound more soluble in non-soluble or weak dissolution.
    In addition, the characterization of this compound is also worthy of investigation. The sub-effect of triethylalkyl group, or the sub-cloud density of aniline group, has a shadow, which affects its oxidation resistance and other qualitative properties. If triethylalkyl has a molecular effect, it may increase the density of the sub-cloud on the aniline group, making it easier to be oxidized; on the contrary, if it has an absorber effect, it may increase its qualitative. Therefore, the chemical properties of 4-alkylphenylamine and 2 - (triethyl alkyl) are caused by the joint action of multiple factors such as the sub-effect and air effect of each substituent, which is worth studying.
    What are the synthesis methods of 4-pyridyl carbamonitrile, 2- (trifluoromethyl) -?
    There are various ways to prepare 4-aminobenzoic acid, 2 - (triethylamino) -, which are described in detail as follows:
    First, p-nitrobenzoic acid is used as the beginning, and p-nitrobenzoic acid is esterified to obtain p-nitrobenzoate. In this process, p-nitrobenzoic acid and alcohols, such as methanol or ethanol, are co-heated and refluxed under acid catalysis to convert the carboxyl group into an ester group. After that, the nitro group is reduced to an amino group with a suitable reducing agent, such as iron powder and hydrochloric acid system, or palladium carbon hydrogenation, to obtain 4-aminobenzoic acid. Finally, the ester group is hydrolyzed under basic conditions, such as treated with sodium hydroxide solution, and then acidified to obtain 4-aminobenzoic acid. < Br >
    Second, starting from p-aminobenzaldehyde. The Knoevenagel condensation reaction of p-aminobenzaldehyde and malonic acid occurs in the presence of basic catalysts such as pyridine. During the reaction, the temperature and the ratio of the reactants are controlled to make the two condensate to form an intermediate product containing double bonds. After that, the intermediate product is oxidized, such as treated with potassium permanganate or other suitable oxidants, the double bond is oxidized and broken and carboxylated to obtain 4-aminobenzoic acid.
    Third, p-chlorobenzoic acid is used as a raw material. First, the p-chlorobenzoic acid is reacted with ammonia under high temperature and pressure and the presence of a catalyst. The chlorine atom is replaced by an amino group to form 4-aminobenzoic acid. This reaction requires the selection of a suitable catalyst to promote the smooth progress of the reaction, and at the same time, the reaction conditions must be strictly controlled to ensure the selectivity and yield of the reaction.
    The above methods have their own advantages and disadvantages. In actual preparation, it is necessary to weigh and choose according to many factors such as the availability of raw materials, cost, difficulty of reaction conditions and product purity requirements.
    In which fields is 4-pyridyl-methylnitrile, 2- (trifluoromethyl) -used?
    4-Alkyl ether, 2 - (triethyl alkyl) This substance is useful in various fields. In the field of medicine, it is often used as a drug carrier because of its specific solubility and stability. It can help the active ingredients of the drug reach a specific part, improve the efficacy of the drug, and reduce the adverse effects on other parts of the body. For example, when making some fat-soluble drugs, it can be used as a carrier to make the drug more easily absorbed by the human body.
    In the chemical industry, it is an important organic raw material. It can be used to synthesize various fine chemicals, such as special paints, fragrances, etc. Because of its active chemical properties, it can participate in a variety of organic reactions. By ingeniously designing the reaction path, a variety of high-value-added products can be generated. < Br >
    In the field of materials science, it may be used to improve material properties. For example, when added to some polymer materials, the flexibility and air permeability of the material can be adjusted. When preparing a specific functional film, an appropriate amount of addition can optimize the mechanical properties and barrier properties of the film, so that it can play a better role in packaging, electronic devices, etc.
    In the field of energy, it has emerged in some new energy-related research. Or it can be used as an electrolyte additive to optimize battery performance, improve battery charging and discharging efficiency and stability, and help the development of new battery technology.
    In laboratory research, it is a commonly used organic solvent. Due to its good solubility to many organic compounds and suitable boiling point, it is convenient for experimental operation. It is often used in organic synthesis reactions, extraction separation and other experimental processes, providing convenience for researchers to study material properties and reaction mechanisms.