4-pyridineacetic acid

4-Pyridyl acetic acid has a wide range of main uses. In the field of medicine, this is an important organic synthesis intermediate. It can be used to prepare many biologically active drugs, such as some anti-tumor drugs, antibacterial drugs, etc. The special structure of the pyridine ring and acetate group endows it with unique chemical properties and biological activities, and can participate in various chemical reactions to construct compounds with specific pharmacological effects.
In the field of materials science, 4-pyridyl acetic acid can be used to synthesize functional materials. For example, it coordinates with metal ions to form metal-organic framework materials (MOFs). Such materials have unique pore structures and adsorption properties, and show potential application value in gas adsorption and separation, catalysis and other fields. It can precisely regulate the structure and properties of materials by virtue of its coordination with metal ions.
In chemical research, 4-pyridyl acetic acid is also a commonly used reagent. It can be used for the study of the reaction mechanism of organic synthesis. Because of its activity check point in the structure, it can participate in various reactions such as nucleophilic substitution and electrophilic substitution. It can help chemists to deeply explore the reaction process and provide an important experimental basis for the development of organic synthesis methodologies. And in analytical chemistry, it can be used as an analytical reagent for qualitative or quantitative analysis of certain substances. By virtue of its chemical reaction with specific substances and the characteristics of the generated products, the detection and determination of target substances can be realized.

4-Pyridyl acetic acid is one of the organic compounds. It has unique physical properties and is widely used in many fields such as chemical industry and medicine.
Looking at its properties, 4-pyridyl acetic acid is white to light yellow crystalline powder under normal conditions. This form is easy to store and transport, and it is easy to operate in various reaction systems. Its melting point is between 116-120 ° C. The characteristic of melting point is crucial for the purification and identification of compounds. By accurately measuring the melting point, the purity of the substance can be determined. If the melting point of the sample is consistent with the literature value and the melting range is narrow, it indicates that the purity is quite high.
In terms of solubility, 4-pyridyl acetic acid is soluble in polar solvents such as water, ethanol, and methanol. When dissolved in water, due to the presence of pyridine rings and carboxyl groups in the molecular structure, hydrogen bonds are formed with water molecules, thereby enhancing the degree of solubility. The property of being soluble in a variety of polar solvents makes it convenient for preparing solutions, chemical reactions, and drug formulations. For example, in drug research and development, a suitable solvent can be selected to prepare drug solutions according to its solubility to achieve better drug efficacy.
The stability of 4-pyridyl acetic acid is also worthy of attention. Under conventional environmental conditions, its properties are relatively stable. However, under extreme conditions such as high temperature, strong acid, and strong base, chemical reactions may occur. For example, when exposed to strong acids, the carboxyl group may protonate, affecting its chemical activity; when exposed to strong bases, the carboxyl group will undergo neutralization reaction and generate corresponding salts. Therefore, when storing, attention should be paid to environmental conditions, and it should be placed in a cool, dry and well-ventilated place to avoid contact with strong acid and alkali substances to prevent deterioration.
This compound also has unique spectral characteristics such as infrared spectroscopy and nuclear magnetic resonance spectroscopy. In infrared spectroscopy, the stretching vibration peak of carboxyl group and the characteristic absorption peak of pyridine ring are all important basis for the identification of this compound. Through spectral analysis, its molecular structure can be accurately determined, providing strong support for its synthesis, application and quality control.

4-Pyridyl acetic acid is one of the organic compounds. It has unique chemical properties. Looking at its structure, it contains a pyridyl ring and an acetic acid group, and this structure gives it special reactivity.
In terms of physical properties, at room temperature, or as a solid, it has a certain melting point and boiling point, and has different solubility in specific solvents. In polar solvents such as water, it can interact with water molecules by hydrogen bonding because it contains carboxyl groups or has a certain solubility.
In terms of chemical properties, carboxyl group activity is quite high. It can neutralize with bases to form corresponding carboxylate and water. Taking sodium hydroxide as an example, 4-pyridyl acetic acid reacts with sodium hydroxide to obtain 4-pyridyl acetic acid and water. This reaction is often used in organic synthesis to prepare carboxylic salts. Carboxylic salts have better solubility in some reaction systems, which is conducive to subsequent reactions.
At the same time, carboxyl groups can participate in the esterification reaction. Under acid catalysis, it reacts with alcohols to form esters and water. If reacted with ethanol, ethyl 4-pyridine acetate and water are formed. This reaction is widely used in the fields of fragrance and drug synthesis, because esters often have unique odors and biological activities.
Pyridine ring is also an important active site of 4-pyridine acetic acid. Pyridine ring is basic and can react with acid to form salts. In case of hydrochloric acid, the corresponding pyridine hydrochloride is formed. In addition, electrophilic substitution reactions can occur on the pyridine ring. Due to the uneven distribution of electron cloud density in the pyridine ring, specific locations are vulnerable to electrophilic reagents, and new functional groups are introduced, providing rich possibilities for organic synthesis.
4-pyridyl acetic acid has important applications in many fields such as organic synthesis and medicinal chemistry due to its special structure and active chemical properties. It can be used as a key intermediate to prepare various compounds with biological activity or special functions.

The preparation method of 4-pyridine acetic acid has been studied by many scholars in the past. The first method can be obtained by the interaction of pyridine and chloroacetic acid in an alkaline environment. First take an appropriate amount of pyridine, place it in the reaction kettle, slowly add chloroacetic acid, then adjust the pH with basic substances, and heat it at controlled temperature to make the two fully react. The temperature and reaction time need to be accurately controlled. If the temperature is too high, side reactions will occur. If it is too low, the reaction will be slow. If the time is insufficient, the product will be impure. If it is too long, the energy consumption will increase.
Both can also be prepared by oxidation with 4-methylpyridine as the starting material. Under specific reaction conditions, the methyl group of 4-methylpyridine is oxidized to a carboxyl group under suitable oxidizing agents, such as potassium permanganate or potassium dichromate, to obtain 4-pyridine acetic acid. However, in this process, the amount of oxidizing agent, the choice of reaction solvent, and the regulation of reaction temperature and time are all key elements. Improper dosage, or excessive oxidation, the product is impure; the solvent is not suitable, the reaction is difficult to go smoothly; inappropriate temperature also affects the yield and quality of the product.
Furthermore, through the ingenious path of organic synthesis, 4-pyridine acetic acid can also be obtained from compounds containing pyridine structures and compounds containing carboxyl groups or carboxyl precursors through specific organic reactions, such as nucleophilic substitution and condensation. This approach needs to carefully design the reaction steps, consider the activity of each reactant, the mildness of the reaction conditions, and the separation and purification of the product, etc., in order to achieve ideal results.

The price of 4-pyridyl acetic acid in the market often varies due to factors such as quality, supply and demand, and purchase quantity. If it is from the ancient meaning of "Tiangong Kaiwu", the price of this product, like all things in the world, fluctuates due to multiple influences.
At the quality end, if 4-pyridyl acetic acid has high purity and few impurities, it is suitable for high-standard uses such as fine chemicals and pharmaceutical research and development, and its price is high. The purity is slightly inferior, and it is only suitable for general industrial use, and the price is slightly lower.
The supply and demand of 4-pyridyl acetic acid is also the main reason. If the market demand for 4-pyridyl acetic acid is strong, but the supply is limited, if the downstream pharmaceutical industry is booming, the demand for it as a synthetic raw material will increase greatly, and the price will rise. On the contrary, if the supply is abundant and the demand is weak, the price will decline.
The amount purchased also affects the price. Large purchases, such as chemical companies buying in bulk, may be discounted by the supplier due to the scale effect, and the unit price is lower. And small purchases, such as scientific research institutions only need a small amount for experiments, the price may be higher.
Roughly speaking, the current market price of 4-pyridyl acetic acid ranges from a few yuan to tens of yuan per gram. However, this is only an approximate number. The actual price still needs to be consulted with chemical raw material suppliers, reagent sellers, etc., depending on the current specific market conditions, and must not be determined.