4-(Phenylamino)pyridine

4- (phenylamino) pyridine is an important member of the field of organic compounds. It has a wide range of uses and plays a key role in many aspects of medicinal chemistry, materials science and organic synthesis.
In the field of medicine, this compound is often used as a drug intermediate. In the process of many drug development, it is necessary to use its special chemical structure to construct molecules with specific biological activities through a series of chemical reactions. Because the structure of 4- (phenylamino) pyridine can interact with specific biological targets, it provides a key foundation for the development of drugs for the treatment of various diseases such as cancer and neurological diseases. For example, in the synthesis of some anti-cancer drugs, 4- (phenylamino) pyridine is used as the starting material. By modifying its structure, it can precisely act on the specific proteins of cancer cells, thereby inhibiting the growth and spread of cancer cells.
In the field of materials science, 4- (phenylamino) pyridine can be used to prepare functional materials. Because of its unique electronic properties, it can affect the electrical and optical properties of materials. For example, in the preparation of organic Light Emitting Diode (OLED) materials, introducing it into the material structure can improve the luminous efficiency and stability of the material, thereby improving the display performance of OLED devices, providing the possibility of achieving high-resolution and high-brightness displays.
In the field of organic synthesis, 4- (phenylamino) pyridine is an extremely useful synthetic building block. Chemists can use its amino-pyridine ring reactivity to carry out various organic reactions, such as nucleophilic substitution, coupling reactions, etc. With the help of these reactions, complex and diverse organic compounds can be constructed, which can inject vitality into the development of organic synthesis chemistry, enrich the variety of organic compounds, and promote the continuous progress of organic synthesis methodologies.

4- (phenylamino) pyridine is a kind of organic compound. Its physical properties are particularly important, and it is related to many uses and characteristics of this compound.
Looking at its appearance, it is often in the form of a crystalline powder that is like white to light yellow. This color and shape can help to distinguish intuitively. The shape of the powder also affects its fluidity and dispersion, which is crucial in many process applications.
When it comes to the melting point, it is about 126-130 ° C. The melting point is an inherent property of the substance, and it is of great significance for its purification, identification and processing. Knowing the melting point accurately can determine the purity of the compound. If the purity is high, the melting point is close to the theoretical value, and the fluctuation range is small.
In terms of boiling point, it reaches about 368.4 ° C. The boiling point reflects the energy required for a substance to change from liquid to gaseous. This high-temperature boiling point indicates that the compound is relatively stable and not volatile at higher temperatures. In high-temperature reaction systems or situations where material stability is required, the application advantage is prominent.
Solubility is also an important physical property. 4- (phenylamino) pyridine is slightly soluble in water, but soluble in organic solvents such as ethanol, chloroform, and dichloromethane. This difference in solubility is due to the different molecular structures of the compounds and the interactions between solvent molecules. Slightly soluble in water, due to the large difference between the molecular polarity of the compound and the water molecule, it is not easy to form an effective interaction; while soluble in organic solvents, due to the similar dissolving force between the organic solvent molecule and the compound molecule. This solubility characteristic provides a basis for its separation, purification and reaction in different solvent systems.
The density is about 1.21 g/cm ³. Although the value seems ordinary, in the fields of chemical production and material preparation, accurate density data is of great significance for calculating dosage, controlling the ratio of the reaction system and studying the accumulation characteristics of substances. The physical properties of 4- (phenylamino) pyridine, from appearance, melting point, boiling point, solubility to density, have their own characteristics and are related to each other, laying the foundation for its application in chemical synthesis, materials science, drug development and many other fields.

4- (phenylamino) pyridine, as well as organic compounds, can be synthesized by various methods. One method is to use pyridine as a group to react with aniline under suitable conditions. A catalyst, such as a copper-based or palladium-based catalyst, needs to be selected. In a high temperature and a specific reaction atmosphere, the 4-position of pyridine is combined with the amino group of aniline to form 4- (phenylamino) pyridine. This reaction requires the control of the atmosphere or the protection of inert gases to avoid side reactions.
Another method uses 4-halogenated pyridine and aniline as materials. The halogen atom of 4-halogenated pyridine has good activity, and can react with aniline through nucleophilic substitution to obtain the target product. However, the activity of the halogen atom is different, and the reaction conditions also need to be fine-tuned. If the halogen atom is chlorine, the reaction conditions may be harsher; if it is iodine, the reaction is easier. And in the reaction, the choice of base is also crucial, such as potassium carbonate, sodium carbonate, etc., can promote the reaction.
Another method is to react with a derivative of pyridine-4-boronic acid and aniline. Pyridine-4-boronic acid and aniline derivatives combine 4- (phenylamino) pyridine through coupling reaction under the catalysis of transition metals. This kind of method has good selectivity and the yield is expected to increase. However, the cost and recovery of transition metal catalysts also need to be considered. In short, there are various methods for synthesizing 4- (phenylamino) pyridine, each with its advantages and disadvantages. The appropriate method should be selected according to the actual needs.

The market price of 4- (phenylamino) pyridine is difficult to determine. The price varies with the supply and demand of the market, the cost of production, and the quality. In the past, the market conditions were peaceful, and its price may have been stable in a certain area. However, in recent years, the market conditions have changed, and its price has also fluctuated.
If there are many producers, the supply exceeds the demand, and the price may decline. The raw materials are easy to cause, the process is refined, and the cost is reduced, the price may also decrease. On the contrary, if the raw materials are thin, the manufacturing process is difficult, and the demand is complex, the price will rise.
Ask the cities, the price range ranges from hundreds of gold to thousands of gold per kilogram or from. If you buy in small quantities, the price may be slightly higher; if you buy in bulk, there may be a discount. And the price of goods from different sources is also different. Those who make high-quality products have high prices; ordinary products have low prices.
To get a confirmed price, it is advisable to consult chemical raw material suppliers, trading houses, or visit relevant e-commerce platforms, and compare the reports of various companies to know the current price. However, the market is impermanent, and the price is indeterminate. The price at that time cannot be determined at this time, and it needs to be observed in real time.

4 - (phenylamino) pyridine is an organic compound. Its storage conditions are related to the stability of its properties and the effect of future use, which cannot be ignored.
This compound should be stored in a cool place, away from the sun. Exposure to sunlight may cause its structure to mutate and lose its inherent properties. Cover light and heat, which can initiate chemical reactions and damage the integrity of its molecules.
And it should be placed in a dry place. The water vapor is dense and easy to get damp. Moisture or hydrolysis changes, resulting in impure ingredients. In a humid environment, the compound is easy to merge with water, and its chemical properties are changed accordingly.
Furthermore, the storage place must be well ventilated. If it is closed in the suffocation, the gas will not circulate, and the harmful gas will gather and not disperse, or come into contact with the compound, causing it to deteriorate. And in a well-ventilated place, the risk of fire and explosion can be reduced, and its safety can be guaranteed.
And it should be stored separately with oxidizing agents, acids, and alkalis. These people are active and coexist with them, which is prone to violent reactions, causing harm to the invisible. If the oxidizing agent encounters it, it may cause the risk of combustion or explosion; if the acid and alkali encounter it, it can also change its chemical properties.
When storing, it is appropriate to use a sealed device. Sealing can prevent external interference and ensure the purity of its composition and stability of its properties. The material of the device must also be selected to prevent it from invading the compound and causing damage to the device.