4 Phenyl 2 Aminopyridine
pyridine pyrrole pyrazine piperidine piperazine

4-Phenyl-2-aminopyridine

    Specifications

    HS Code

    899789

    Chemical Formula C11H10N2
    Molecular Weight 170.21 g/mol
    Appearance Solid (usually white or off - white powder)
    Odor Typically odorless
    Melting Point 145 - 148 °C
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
    Pka Around 5 - 6 (approximate value for the pyridine - NH2 group)
    Density Approx. 1.15 g/cm³ (estimated)

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    General Information
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    Frequently Asked Questions

    As a leading 4-Phenyl-2-aminopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Phenyl-2-aminopyridine?
    4-Phenyl-2-aminopyridine is a class of organic compounds. It has a wide range of uses and has important applications in many fields.
    In the field of medicinal chemistry, 4-phenyl-2-aminopyridine is often the key intermediate of traditional Chinese medicine. Because of its unique structure, it can be prepared by chemical synthesis of various biologically active drugs. For example, in the development of some anti-cancer drugs, 4-phenyl-2-aminopyridine is used as the starting material, and through a series of chemical reactions, a molecular structure that is in line with the target of cancer cells is constructed, so as to inhibit the growth and proliferation of cancer cells.
    In the field of materials science, 4-phenyl-2-aminopyridine also has outstanding performance. It can participate in the preparation of organic materials with special functions, such as optoelectronic materials. Because of its certain electron transport properties and optical properties, it can be used as a material component of the light-emitting layer or the transport layer in the manufacture of organic Light Emitting Diode (OLED) devices to improve the luminous efficiency and stability of the device, which contributes to the development of display technology.
    In addition, 4-phenyl-2-aminopyridine may also have potential uses in agricultural chemistry. It can be used to develop new pesticides, and through the modification and modification of its structure, it can have specific biological activities to effectively control crop diseases and pests, ensure the harvest of agricultural production, and help reduce the adverse effects of traditional pesticides on the environment, in line with the trend of green agriculture.
    In summary, 4-phenyl-2-aminopyridine has shown important value in many fields such as medicine, materials, agriculture, etc. With the continuous progress of science and technology, its application prospects will also be broader.
    What are the physical properties of 4-Phenyl-2-aminopyridine?
    4-Phenyl-2-aminopyridine, this is an organic compound. Its physical properties are quite important and it is widely used in the field of organic synthesis.
    Let's talk about the appearance first. At room temperature, 4-phenyl-2-aminopyridine is often in the state of white to light yellow crystalline powder, with fine texture and uniform appearance like fine sand. This color feature is easy to identify, and in many reaction systems, the reaction process can be inferred depending on its appearance.
    Besides the melting point, its melting point is about 125-127 ° C. The melting point is the inherent property of the substance, and this specific melting point indicates the state of the intermolecular force of 4-phenyl-2-aminopyridine. When heated to this temperature, the substance gradually melts from solid to liquid, which lays the foundation for its participation in various heat-driven reactions.
    Solubility is also critical, 4-phenyl-2-aminopyridine is slightly soluble in water. Water is a common solvent, and the slightly soluble properties show that its molecular polarity is different from that of water molecules. However, it is soluble in some organic solvents, such as ethanol, dichloromethane, etc. In organic synthesis experiments, according to this solubility, suitable solvents can be selected to help it disperse and participate in the reaction, optimize the reaction environment, and improve the reaction efficiency. < Br >
    The physical properties of 4-phenyl-2-aminopyridine, from its appearance, melting point to solubility, are the cornerstones of its application in organic synthesis and other fields. Synthesizers can make good use of this compound to achieve the expected synthesis goal.
    What are 4-Phenyl-2-aminopyridine synthesis methods?
    The synthesis methods of 4-phenyl-2-aminopyridine have existed in ancient times and are of various kinds. Today, I will describe several common methods in detail.
    First, pyridine derivatives are used as starting materials. First, a suitable pyridine compound is taken and a phenyl group is introduced at a specific position. This step often requires the help of specific catalysts and reaction conditions. For example, under the action of certain metal catalysts such as palladium catalysts, the pyridine ring is reacted with benzene halide to form a phenyl-containing pyridine intermediate. Subsequently, the amination reaction is carried out at a specific position on the pyridine ring. Generally, the aminolysis reaction can be used to convert the intermediate into 4-phenyl-2-aminopyridine under suitable temperature, pressure and catalyst conditions. This method route is relatively direct, but the reaction conditions of each step need to be precisely controlled to ensure the smooth progress of the reaction and the purity of the product.
    Second, the target product is constructed by using aniline compounds and pyridine derivatives. First, the aniline is properly modified to have an activity check point for reacting with pyridine derivatives. Pyridine derivatives also need to be pretreated accordingly so that the two can be combined smoothly. After that, through the condensation reaction, in a suitable reaction solvent and catalytic system, the connection of the two is promoted, and then the molecular structure of 4-phenyl-2-aminopyridine is gradually constructed. This process requires fine regulation of the reaction process. Due to the possible occurrence of various side reactions in the reaction, it is necessary to optimize the reaction parameters, such as temperature, reaction time, and the proportion of reactants, etc., in order to improve the yield of the target product.
    Third, it is synthesized by multi-step tandem reaction. Starting from a simple starting material, through a series of successive reactions, in the same reaction system or in the step-by-step conversion process, pyridine, phenyl and amino groups are sequentially constructed. Although the process is complicated, this method has the advantages of high atomic economy and simple operation. It is necessary to skillfully design the reaction sequence and conditions, and take advantage of the characteristics of various organic reactions to connect the reactions in each step to synthesize 4-phenyl-2-aminopyridine efficiently.
    4-Phenyl-2-aminopyridine in what areas?
    4-Phenyl-2-aminopyridine, which is used in various fields. In the field of medicinal chemistry, it is often a key raw material for the creation of new drugs. Due to its unique chemical structure, it can interact with specific targets in organisms, or have various pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor. For example, based on it, chemists can modify and synthesize compounds that have therapeutic effects on specific diseases, such as targeted drugs targeting specific receptors in certain cancer cells, which is expected to open up new avenues for cancer treatment.
    In the field of materials science, 4-phenyl-2-aminopyridine also has outstanding performance. It can be used as a component of organic semiconductor materials for the preparation of organic Light Emitting Diodes (OLEDs), field-effect transistors and other devices. Its structure endows the material with unique electrical and optical properties, which can improve the luminous efficiency, stability and carrier transport performance of the device, and promote the development of display technology and electronic devices.
    Furthermore, in the field of coordination chemistry, 4-phenyl-2-aminopyridine can be used as a ligand to coordinate with metal ions to construct complexes with diverse structures. Such complexes may have unique catalytic properties and serve as efficient catalysts in organic synthesis reactions, promoting various chemical reactions, improving reaction efficiency and selectivity, and providing new methods and paths for organic synthesis chemistry.
    What is the market outlook for 4-Phenyl-2-aminopyridine?
    4-Phenyl-2-aminopyridine is a class of organic compounds. In the current market, its prospects are quite promising.
    From the perspective of chemical pharmaceuticals, this compound is a key raw material for traditional Chinese medicine. The development and creation of many new drugs often rely on its participation in the reaction to form a specific molecular structure and give the drug a unique therapeutic effect. Today, the pharmaceutical industry is hungry for innovative drugs. The market demand for 4-phenyl-2-aminopyridine is on the rise because it can help develop novel and efficient drugs.
    In the field of materials science, with the rapid development of high-tech materials, it has also emerged. For example, in the preparation of some functional polymer materials, 4-phenyl-2-aminopyridine can be introduced into the polymer chain as a special structural unit, thereby improving the properties of the material, such as improving the stability, conductivity or optical properties of the material. With the vigorous rise of emerging industries such as electronics and optics, the demand for materials with special properties is increasing, and the application prospects of this compound in the field of materials are also increasingly broad.
    However, its market development also faces some challenges. The process of synthesizing 4-phenyl-2-aminopyridine may have high complexity and cost. To expand the market on a large scale, it is necessary to optimize the synthesis process and reduce costs and increase efficiency. And environmental regulations are becoming more and more stringent, and the waste treatment and environmental impact involved in the synthesis process are also urgent problems to be solved.
    Even though there are challenges ahead, driven by strong demand in the fields of medicine and materials, 4-phenyl-2-aminopyridine is still expected to occupy an important position in the future market and gain further expansion and sublimation.