4-phenoxy pyridine

4-Aminopyridine has two main uses. First, in the field of medicine, it has great merit. It can act on potassium ion channels, regulate nerve conduction, and is quite beneficial in the treatment of neurological diseases such as multiple sclerosis. Doctors use it to treat patients, help them relieve symptoms, and improve the recovery of neurological function. Like ancient physicians, who used medicinal stones to treat diseases and save people, 4-aminopyridine is also a good medicine today, relieving pain for patients in a moment.
Second, in the field of organic synthesis, 4-aminopyridine is an important intermediate. Chemists use this to synthesize many organic compounds and enrich the variety of chemical substances. Like a craftsman building a building with wood and stone, a chemist builds a complex molecular structure based on 4-aminopyridine. After a series of chemical reactions, substances with special properties and uses are derived, either as new materials or as precursors to new drugs. Therefore, 4-aminopyridine plays a pivotal role in medicine and organic synthesis, and is an indispensable substance for chemistry and medicine in this world.

4-Aminopyridine is an organic compound, and its physical properties are as follows:
In terms of concept, this substance is a colorless to light yellow crystalline solid, and its morphology is stable under normal temperature and pressure. Its melting point is about 158-162 ° C. In this temperature range, the solid will melt into a liquid state. The boiling point reaches 273-274 ° C. When the temperature reaches this point, the liquid 4-aminopyridine will transform into a gaseous state.
In terms of solubility, 4-aminopyridine is soluble in water and in organic solvents such as ethanol and ether. This property is due to the presence of amino groups in its molecular structure. Amino groups have a certain polarity and can interact with polar groups in water and some organic solvents, thus causing them to dissolve.
4-aminopyridine does not have a strong odor at room temperature, but when it is close to a fine smell, there will be a weak special odor. Its density is slightly higher than that of water, and if it is placed in water, it will sink to the bottom.
In addition, 4-aminopyridine has sublimation properties. Although the sublimation phenomenon is not significant at room temperature and pressure, it can be directly converted from solid to gaseous under specific conditions, such as decompression and moderate heating, without going through the liquid stage.
In addition, 4-aminopyridine is hygroscopic. If exposed to air, it will absorb moisture in the air and cause its own deliquescence. Therefore, it needs to be stored in a dry environment to prevent deterioration.

4-Aminopyridine is an organic compound. It is active and has many unique chemical properties.
Looking at its structure, it contains nitrogen heterocycles and amino groups, which endows it with specific reactivity. In terms of acidity and alkalinity, amino groups can exhibit alkalinity and can form salts with acids. Because nitrogen atoms have solitary pairs of electrons and can accept protons, they can react with acids.
In terms of reactivity, 4-aminopyridine can participate in many nucleophilic substitution reactions. Because its amino group is a good nucleophilic reagent, when encountering suitable electrophilic reagents, such as halogenated hydrocarbons, the nitrogen atom of the amino group will attack the carbon atom of the electrophilic reagent, and the halogen will leave, thus forming new compounds. This reaction is widely used in the field of organic synthesis, and can be used to construct complex organic molecular structures.
Furthermore, 4-aminopyridine also exhibits in redox reactions. The electron cloud density of the nitrogen atom can be changed due to changes in redox conditions, which in turn affects the reactivity and properties of the whole molecule. Under specific oxidation conditions, the nitrogen atom may be oxidized, resulting in differences in molecular structure and properties.
In addition, the conjugate system of 4-aminopyridine also affects its chemical properties. The conjugate structure delocalizes the intra-molecular electrons, enhances the stability of the molecule, and also affects its spectral properties. In the UV-visible spectrum, due to the existence of conjugated systems, there will be specific absorption peaks, which can be used for qualitative and quantitative analysis of the compound.
In summary, 4-aminopyridine, with its unique structure, presents a variety of chemical properties, and is of great value in many fields such as organic synthesis and analytical chemistry. It is a substance that cannot be ignored in chemical research and application.

There are many ways to synthesize 4-aminopyridine, each with its own advantages and disadvantages, and it is selected according to different needs and situations.
First, pyridine is used as the starting material, through nitrification reaction, nitropyridine can be obtained, and then iron powder, hydrochloric acid, etc. are used as the reducing agent to convert the nitro group into an amino group, and then 4-aminopyridine is obtained. The raw materials of this method are easy to obtain, the process is clear, but the nitrification step requires strict control conditions, and the subsequent treatment of the reducing agent is complicated, which also has an impact on the environment.
Second, starting from 2-chloropyridine, through the aminolysis reaction, the chlorine atom is replaced by an amino group, and the target product can be obtained. The reaction conditions of this method are mild and the yield is quite high, but the price of 2-chloropyridine is relatively high, and the cost restricts its large-scale application.
Third, using pyridine-N-oxide as raw material, first nitrifying, then reducing nitro, and reducing N-oxide at the same time, the final 4-aminopyridine is obtained. This path can effectively improve the reaction selectivity and reduce side reactions, but the preparation of pyridine-N-oxide is slightly complicated, and the reaction steps are increased, and the overall cost increases.
Fourth, 4-aminopyridine is used as raw material, methyl oxide is first used as carboxyl group, and then the carboxyl group is converted into amino group through Hoffman degradation reaction, so as to obtain 4-aminopyridine. Although this method has many steps, the raw materials are widely sourced, and if the reaction conditions of each step can be optimized, it also has certain advantages.
In short, there are various methods for synthesizing 4-aminopyridine, and it is necessary to weigh the advantages and disadvantages according to the actual situation, such as raw material cost, equipment conditions, product purity requirements, etc., and choose the best method.

In today's world, the price of 4-aminopyridine in the market varies from top to bottom, and it is difficult to determine an exact number. Its price often changes due to many reasons, such as supply and demand conditions, manufacturing costs, market regulations, and sources of materials.
If there is a large number of supply and demand, and the supply is small, the price will increase; if the supply exceeds the demand, the price will drop. Furthermore, the manufacture of this drug requires various raw materials, and it takes manpower and material resources. Such costs are also the main reasons for pricing. If the price of raw materials rises, or the manufacturing method is complicated, the cost will increase, and the price of the drug will also rise.
Depending on the rules of the market, the laws of different places are different, and the supervision is different, or the price is different. And the sources of materials are different, and the quality is different, which can also make the price different. The best one has a high price, and the second one has a low price.
Roughly speaking, the price per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximation, and the actual price may vary depending on time and place. Those who buy this product need to check the market conditions in detail and compare them in many ways to get the right price.