4-oxo-1,4-dihydropyridine-3-sulfonic acid

4-Oxo-1,4-dihydropyridine-3-sulfonic acid is a kind of organic compound. Its chemical structure contains a pyridine ring, which has special modifications at the 1,4 positions. A double bond is formed between the 1st and 4th positions, and the 4th position is occupied by a carbonyl group (oxo, that is, C = O structure). This carbonyl group imparts specific chemical activity and reactivity to the molecule.
In addition, the 3rd position of the pyridine ring is connected to a sulfonic acid group (-SO 🥰 H). The sulfonic acid group is strongly acidic, which can make the compound exhibit unique acid-base properties and ionization behavior under specific conditions. The nitrogen atom of the pyridine ring, due to its lone pair of electrons, can participate in a variety of chemical reactions, such as coordinating with metal ions or acting as an electron receptor in organic reactions.
The overall structure of this compound makes it potential for applications in pharmaceutical chemistry, materials science and other fields. The uniqueness of its structure may enable it to participate in specific chemical reactions and be used to synthesize compounds with special functions. In drug development, or as a lead compound, it can be structurally modified to obtain drug molecules with specific biological activities. In the field of materials, its acidic sulfonic acid group and reactive pyridine ring can be used to construct functional materials, such as ion exchange resins or materials with special adsorption properties.

4-Oxo-1,4-dihydropyridine-3-sulfonic acid, which has a wide range of uses. In the field of medicine, it can be used as an important intermediate to help pharmaceutical chemists create compounds with unique structures and specific activities. For example, when developing cardiovascular drugs, this is used as a starting material to build key pyridine structures through a series of reactions, optimize the ability of drugs to bind to targets, and improve drug efficacy.
In the chemical industry, it can participate in the synthesis of functional materials. Because it contains specific functional groups, it can be polymerized with other monomers to give materials special properties, such as improving the solubility and thermal stability of polymer materials, laying the foundation for the preparation of high-performance coatings, plastics, etc.
In scientific research, 4-oxo-1,4-dihydropyridine-3-sulfonic acid is often used as a model compound. By studying its reaction characteristics and spectral properties, researchers have gained insight into the organic reaction mechanism, expanded their theoretical knowledge of organic chemistry, and provided ideas and basis for the development of new reactions and new synthesis methods.

To prepare 4-oxo-1,4-dihydropyridine-3-sulfonic acid, the method of organic synthesis is often followed. There are three methods, and listen to me one by one.
First, pyridine is used as the starting material. First, under specific oxidation conditions, pyridine is oxidized at the ortho-position of the nitrogen atom of the pyridine ring with a suitable oxidant, such as periodic acid, etc., to obtain the corresponding pyridine oxide intermediate. This intermediate introduces a sulfonic acid group at a specific position in the pyridine ring under the action of a sulfonating agent, such as fuming sulfuric acid or chlorosulfonic acid. Subsequently, by reduction means, such as using reducing agents such as lithium aluminum hydride, the pyridine oxide is partially reduced to the 1,4-dihydropyridine structure, while retaining 4-carbonyl and 3-sulfonic acid groups, so as to obtain the target product.
Second, the carbonyl-containing compounds such as ethyl acetoacetate are used as raw materials with ammonia and reagents with sulfonic acid groups. Ethyl acetoacetate and ammonia undergo a condensation reaction first to form the precursor structure of the pyridine ring. The reaction conditions need to be precisely controlled, such as temperature, pH, etc., so that the condensation reaction can proceed smoothly. During or after the condensation process, the sulfonic acid group is ingeniously introduced. Reagents containing sulfonic acid groups can be combined with pyridine ring precursors by reactions such as nucleophilic substitution, and then through appropriate oxidation or reduction steps, the oxidation state of the pyridine ring can be adjusted to obtain 4-oxo-1,4-dihydropyridine-3-sulfonic acid.
Third, the reaction catalyzed by transition metals. Select suitable transition metal catalysts, such as palladium, copper, etc. Compounds containing unsaturated bonds such as alkenyl groups and alkynyl groups and nitrogen-containing and sulfonic acid precursor reagents are used as substrates. Under the catalysis of transition metals, the pyridine ring structure is constructed by cyclization reaction. The reaction system needs to be strictly anhydrous and oxygen-free, and the selection of ligands is also particular, so that the reaction selectively generates 4-oxo-1,4-dihydropyridine-3-sulfonic acid. Although this method may be slightly complicated, it has many advantages for precise control of product structure and selectivity.

4-Oxo-1,4-dihydropyridine-3-sulfonic acid is an organic compound. Its physical properties are crucial and are relevant to the application of this compound in many fields.
First of all, its appearance usually appears as a solid state. This solid form may have a specific crystal structure, which has a great influence on its physical properties. For example, the crystal form affects its density, resulting in different packing compactness, which in turn affects the relevant reaction process.
Melting point is also one of the important physical properties. At a specific melting temperature, the compound changes from a solid state to a liquid state. This melting point value depends on intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. Strong intermolecular forces often cause higher melting points, and more energy is required to overcome these forces to achieve phase transition.
Solubility cannot be ignored either. In different solvents, its solubility varies. In polar solvents, due to the polarity of the sulfonic acid group in the molecule, or exhibits good solubility, it can form hydrogen bonds or other interactions with solvent molecules; in non-polar solvents, the solubility is poor, because non-polar solvents interact weakly with polar sulfonic acid groups and pyridine rings.
Furthermore, its density determines the mass of the substance per unit volume. In preparation and application, this characteristic is related to the calculation of material dosage, the ratio of the reaction system, etc. Only by accurately knowing the density can we ensure the accuracy of the experiment and production process.
In addition, the color of the compound is also characterized by physical properties. Although the color information may be difficult to determine, its color may reflect the molecular structure and purity. High-purity samples may have specific colors, and the presence of impurities may cause color changes.
In summary, the physical properties of 4-oxo-1,4-dihydropyridine-3-sulfonic acid, such as appearance, melting point, solubility, density and color, are interrelated and of great significance to its research and application, helping researchers to rationally use this compound in chemical synthesis, materials science and other fields.

4-Oxo-1,4-dihydropyridine-3-sulfonic acid is of great concern to many people in today's market prospects. Looking at its characteristics, this compound has a unique chemical structure and potential application value.
In the field of medicine, its structure is similar to that of some biologically active molecules, or it can be used as an intermediate for drug synthesis. In recent years, there is a growing demand for novel intermediates in pharmaceutical research and development. If they can be experimentally verified to have good pharmacological activity and safety, they will emerge in the drug creation market and provide new avenues for the treatment of many diseases. The market prospect is quite promising.
In the field of materials science, or can be used to synthesize materials with specific functions. Current material research aims to develop high-performance, multi-functional materials. If 4-oxo-1,4-dihydropyridine-3-sulfonic acid can impart special optical, electrical or mechanical properties to the material, it will open up new material application fields, and the market potential is huge.
However, its market development also has challenges. First, the synthesis process needs to be optimized to improve yield and reduce costs in order to gain a foothold in the market competition. Second, in-depth research on its performance and application is required to obtain sufficient data support in order to gain market recognition.
Overall, 4-oxo-1,4-dihydropyridine-3-sulfonic acid faces challenges, but with its unique structure and potential applications, if the difficulties can be overcome, it is necessary to achieve good development in the pharmaceutical and materials markets, and the prospects are promising.