4-oxo-1,4-dihydropyridine-2,6-dicarboxylate

4 - oxo - 1,4 - dihydropyridine - 2,6 - dicarboxylate, this is the name of an organic compound. Looking at its name, its structure can be deduced according to the naming rules of organic chemistry. "Pyridine" is a pyridine with a six-membered nitrogen heterocycle structure. "1,4 - dihydropyridine" indicates that the 1,4 positions of the pyridine ring are hydrogenated, resulting in the saturation of the double bond of the original pyridine ring. "4 - oxo" shows that the 4-position oxygen atom exists in the form of a carbonyl group, that is, a C = O structure. "2,6 - dicarboxylate" shows that the 2,6 positions of the pyridine ring are connected with a carboxylic acid ester group, -COOR structure (R is a hydrocarbon group).
The structure of this compound is composed of a pyridine ring as the core, hydrogenated at the 1st and 4th positions, with a carbonyl group at the 4th position, and a monocarboxylic acid ester group at the 2nd and 6th positions. The overall structure has a conjugated system, and the presence of pyridine rings and carbonyl groups endows the compound with specific chemical activities and physical properties. In the field of organic synthesis, it may be used as a key intermediate to introduce various functional groups through its reactivity at different check points to construct more complex organic molecules.

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylate (4-oxo-1,4-dihydropyridine-2,6-dicarboxylate) is a class of organic compounds with specific structures, which have attracted much attention in the fields of organic synthesis and medicinal chemistry. Its main physical properties are as follows:
- ** Properties **: Usually solid, due to the existence of various forces between molecules, such as van der Waals force, hydrogen bonds, etc., to promote the orderly arrangement of molecules, and then to assume a solid state. Different substituents will cause their crystalline morphologies to vary, either needle-like crystals or bulk crystals. < Br > - ** Melting point **: varies depending on the substituents in the molecular structure. If the substituent can enhance the intermolecular force, such as the presence of long-chain alkyl or polar groups, the intermolecular binding can be tighter, and the melting point will increase; conversely, if the substituent is a small non-polar group, the intermolecular force is weaker, and the melting point is relatively low. Generally speaking, the melting point ranges from tens of degrees Celsius to hundreds of degrees Celsius.
- ** Solubility **: The solubility of the substance in organic solvents is affected by molecular polarity. In view of its structure containing polar carboxyl ester groups, it has a certain solubility in polar organic solvents such as ethanol and acetone, because hydrogen bonds or dipole-dipole interactions can be formed between polar solvents and compounds. However, in non-polar solvents such as n-hexane and benzene, the solubility is very small because of the weak force between it and non-polar solvents.
- ** Stability **: Under normal conditions, 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate is relatively stable. However, in strong acids, strong bases or high temperature environments, its structure will be affected. Because the ester group in the molecule is prone to hydrolysis when exposed to strong acids or bases, the original structure is destroyed; high temperature may also cause intramolecular rearrangement or decomposition reactions, reducing its stability.

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylate is used in medicine, pesticides, materials and other fields.
In the field of medicine, it exhibits excellent pharmacological activity. Due to its unique chemical structure, it can act on many physiological targets in the human body. For example, in the prevention and treatment of cardiovascular diseases, it can regulate the tension of blood vessels, stabilize blood pressure, and improve blood circulation. And it also affects the nervous system, or can be used in the treatment of some neurological diseases, such as relieving nerve pain and assisting in the repair of nerve function.
As for the field of pesticides, 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate also has outstanding performance. It can be used as an efficient insecticide, showing strong toxicity to many pests, can effectively kill pests that harm crops, ensure the growth of crops, and improve the yield and quality of crops. At the same time, it also inhibits some plant diseases, protects the health of plants, and reduces the infestation of diseases.
In the field of materials, it can participate in the synthesis of new materials. Because of its specific chemical properties, it can react with other substances to build unique material structures. The resulting materials may have excellent physical properties, such as high strength, good flexibility, etc., and can be used in aerospace, automobile manufacturing and other industries to manufacture high-performance parts, improve the performance and quality of materials, and promote the development of related industries.
From this point of view, 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate plays a key role in many important fields, with broad application prospects and significant practical value.

There are many ways to prepare 4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid esters. One method is the Hantzsch reaction, which is a classic synthesis path. Ethyl acetoacetate, formaldehyde and ammonia are used as raw materials to react under appropriate conditions. During the reaction, ethyl acetoacetate and formaldehyde are condensed first, followed by ammonia to participate in the reaction. After a series of complex chemical changes, 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate is finally obtained. The reaction needs to be carried out in a suitable temperature and solvent environment, often using ethanol as a solvent, and the temperature is controlled within a certain range, so that the reaction can occur smoothly and obtain a considerable yield.
There is also a method of using pyridine compounds as starting materials. Appropriate chemical modification of the pyridine ring begins with the introduction of specific substituents on the pyridine ring, and then converts to 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate through redox and other steps. In the oxidation step, it is crucial to choose a suitable oxidant. Improper oxidant or excessive oxidation will affect the purity and yield of the product.
In addition, there are also metal-catalyzed synthesis methods. Specific metal catalysts, such as palladium and copper, are used to catalyze the reaction of related organic substrates under the synergistic action of organic ligands. In this process, the activity and selectivity of metal catalysts have a great impact on the reaction. By adjusting the reaction conditions, such as temperature, pressure, catalyst dosage, etc., the reaction can be optimized and the quality and output of the product can be improved. All preparation methods have their own advantages and disadvantages. In practical application, it should be carefully selected according to specific needs and conditions.

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylate is a class of organic compounds with a specific structure. Its market prospect is worth exploring.
From the perspective of the medical field, such compounds show potential medicinal value. Many studies have revealed that they may have the effect of regulating the cardiovascular system, can act on related ion channels, and affect physiological indicators such as blood pressure and heart rate. In today's society, cardiovascular diseases are raging, and the patient population is huge. If this compound can be deeply developed and targeted drugs can be developed, the market prospect will be broad. And the pharmaceutical industry has a constant demand for new effective drugs. Once its medicinal properties are fully verified, it will definitely occupy a place in the cardiovascular drug market.
In the field of materials science, 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate may be involved in the synthesis of materials with special properties. For example, in the preparation of some functional polymer materials, it may be used as a key structural unit to endow materials with unique physical and chemical properties, such as optical and electrical properties. With the development of science and technology, the demand for new functional materials is increasing, from electronic devices to aerospace fields, all are eager for special performance materials. If new materials based on this compound can be successfully developed, it will also have a considerable share in the materials market.
However, it is also necessary to face up to the challenges it faces. The process or complexity of synthesizing such compounds, and cost control is a major problem. If the synthesis route cannot be optimized and production costs reduced, it will be hindered in large-scale commercial production and marketing activities. And in pharmaceutical applications, strict safety and efficacy evaluation is indispensable. This process is time-consuming and labor-intensive, and requires a lot of resources.
But overall, if 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate can overcome the obstacles of synthesis and evaluation, it has significant market potential in the fields of medicine and materials, and is expected to bloom in the future market.