4-Methylpyridine-3-carboxaldehyde

4-Methylpyridine-3-carboxaldehyde, which is 4-methylpyridine-3-formaldehyde, is an organic compound. Its physical properties are unique, it is related to many properties of substances, and it is very important for chemical research and application.
This compound is often liquid at room temperature, with a specific color and appearance. Generally speaking, its color is light, or nearly colorless and transparent, but due to the influence of purity or impurities, the color may change slightly.
4-methylpyridine-3-formaldehyde has a significant odor and has a special pungent odor. Such odors are strong and can be keenly perceived by humans, and caution is required when handling or contacting, because it may irritate the human respiratory tract and skin.
Melting point and boiling point are also key physical properties. The melting point determines the temperature of a compound from solid to liquid, and the boiling point is related to the temperature from liquid to gaseous. The melting point of 4-methylpyridine-3-formaldehyde is about -20 ° C, and the boiling point is between 210-212 ° C. The boiling point indicates that it boils at a relatively high temperature, which is of great significance for separation, purification and control of reaction conditions.
Solubility is also an important physical property. 4-methylpyridine-3-formaldehyde is soluble in common organic solvents, such as ethanol, ether, chloroform, etc. Due to the principle of similar miscibility, its molecular structure is similar to that of organic solvents. However, its solubility in water is limited, because although there are aldehyde groups in the molecule that can form hydrogen bonds with water, the pyridine ring has strong lipophilicity with methyl groups, limiting its solubility in water.
In terms of density, the density of 4-methyl pyridine-3-formaldehyde is about 1.11 g/cm ³, which is slightly larger than that of water. This density characteristic needs to be taken into account when it involves liquid-liquid separation or mixture preparation. Substances of different densities will be stratified when mixed or left to stand.
In summary, the physical properties of 4-methylpyridine-3-formaldehyde, such as appearance, odor, melting point, solubility, and density, lay the foundation for its application in organic synthesis, medicinal chemistry, and other fields. Researchers must be familiar with these properties in order to use this compound properly.

4-Methylpyridine-3-formaldehyde, this is an organic compound. Its chemical properties are unique, containing a pyridine ring and an aldehyde group, which endow the compound with various activities.
In terms of its physical properties, it is mostly liquid or solid at room temperature, with a specific melting point and boiling point. In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and ether, but its solubility in water may be limited. This is due to the interaction of the polarity of the intramolecular pyridine ring with the aldehyde group and the structure of the hydrocarbon group.
Its chemical properties are active, and the aldehyde group can undergo many reactions. In the oxidation reaction, it can be oxidized to 4-methylpyridine-3-carboxylic acid by mild oxidizing agents such as Torun reagent, showing the phenomenon of silver mirror; in case of strong oxidizing agents such as potassium permanganate, it can also be oxidized, and the product may vary depending on the reaction conditions.
The aldehyde group can undergo nucleophilic addition reaction with compounds containing active hydrogen. For example, under acid catalysis with alcohols, acetal is formed, which is often used as a means of carbonyl protection in organic synthesis. With ammonia and its derivatives, such as hydroxylamine, hydrazine, etc., can form oxime and hydrazone compounds, which are often used for the identification of aldehyde groups and organic synthesis.
The pyridine ring part is also chemically active. Due to the electronegativity of the nitrogen atom, the electron cloud density distribution of the pyridine ring is uneven, and the electron cloud density of the α and γ positions is relatively low, which is prone to electrophilic substitution reactions, and the substituents mostly enter the β position. For example, under specific conditions, electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can occur.
In addition, the methyl group in the 4-methyl pyridine-3-formaldehyde molecule can be oxidized and halogenated under appropriate conditions, which further enriches the chemical reaction types of the compound and makes it valuable in the field of organic synthesis. It can be used to prepare various organic compounds such as drugs, pesticides, and functional materials.

The synthesis of 4-methylpyridine-3-formaldehyde is often done by numerical methods. One method can also be started from the corresponding pyridine derivative. With 4-methylpyridine as the base, the 3-position of 4-methylpyridine is functionalized with a specific reagent under appropriate conditions. If the 3-position is halogenated with a suitable halogenating agent, 4-methyl-3-halogenated pyridine is obtained. This halogenate is then reacted with a metal reagent, such as magnesium, to obtain a Grignard reagent. The Grignard reagent is hydrolyzed with a suitable carbonyl source, such as dimethylformamide (DMF), to obtain 4-methylpyridine-3-formaldehyde. < Br >
Another method is obtained by oxidation of pyridine containing suitable substituents. Such as 4-methylpyridine-3-methanol, a suitable oxidizing agent can be selected, such as Dess-Martin periodinane, under mild conditions, the hydroxyl group is oxidized to an aldehyde group to obtain the target product. This oxidation method has mild conditions, good yield, and few side reactions.
Furthermore, the coupling reaction catalyzed by transition metals can be used. A halide containing a pyridine structure and an aldehyde-containing precursor can be synthesized by coupling reaction under the action of a transition metal catalyst such as palladium catalyst. 4-Methylpyridine-3-formaldehyde can also be obtained by the Suzuki coupling reaction of 4-halo-3-methylpyridine and formyl borate under the condition of palladium catalysis and the presence of a base. This transition metal catalysis method has high selectivity and can construct complex pyridinaldehyde structures. In short, each synthesis method has its own advantages and disadvantages, and the experimenter needs to weigh the factors such as raw material availability, reaction conditions, yield and selectivity.

4-Methylpyridine-3-formaldehyde, this substance is useful in various fields. In the field of pharmaceutical chemistry, it is an important intermediate in organic synthesis. The preparation of many drugs depends on its participation. Based on it, complex drug molecular structures can be constructed, and then good drugs against various diseases can be created, such as some drugs with specific targeted therapeutic functions.
In the field of materials science, it also has value that cannot be ignored. Through specific chemical reactions, it can be integrated into polymer material systems to improve the properties of materials, such as enhancing the stability, heat resistance or endowing them with special optical and electrical properties, which greatly contributes to the research and development of new functional materials.
In the manufacture of fine chemicals, 4-methylpyridine-3-formaldehyde also plays a key role. It can be used to synthesize fine chemicals such as fragrances and dyes. In the synthesis of fragrances, its unique structure can impart a different flavor to fragrances and add uniqueness to products; in the synthesis of dyes, it can affect key performance indicators such as color and fastness of dyes.
Furthermore, in the basic research level of organic synthetic chemistry, as a typical nitrogenous aldehyde compound, it provides an important research object for scientists to explore new reaction mechanisms and expand organic synthesis methods. The exploration of many new catalytic reactions or synthesis strategies often uses it as a substrate to promote the continuous development of organic chemistry.

What you are asking about is the market price of 4-methylpyridine-3-formaldehyde. However, the market price of this compound is difficult to generalize, and it is also subject to many factors.
The first to bear the brunt is the cost of raw materials. If the raw materials required for its preparation are scarce and expensive, the price of 4-methylpyridine-3-formaldehyde will also rise. Such as the origin of raw materials, harvest, market supply and demand situation, etc., can affect the cost of raw materials.
The second is related to the production process. A sophisticated and efficient production process can reduce production costs, which in turn affects its market price. If a factory has advanced synthesis methods that can increase productivity and reduce energy consumption, its products will have an advantage in market pricing.
Furthermore, the market supply and demand relationship is a key factor. If the market demand for this compound is strong and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may fall.
In addition, the scale of production also has an impact. Large-scale production can often reduce unit production costs due to scale effects, making product prices more competitive.
Differences in sales channels and regions cannot be ignored. Different sales channels, such as directly to manufacturers or through distributors, may have different prices. And the market environment and economic level vary from place to place, and the price will fluctuate.
As for the exact market price, you need to check the chemical product trading platform in real time, consult relevant suppliers or industry insiders, and get it. Due to the changing situation of the chemical market, prices often change with the above factors, and it is difficult to give you a fixed value.