4-methylpyridine-3-boronic acid

4-Methylpyridine-3-boronic acid has unique chemical properties. This compound contains a pyridine ring and a boric acid group, which give it many properties.
First, the boric acid group is weakly acidic and can react with hydroxyl compounds such as alcohols and phenols under suitable conditions to form borate esters. The reaction is often reversible and is affected by reaction conditions such as temperature and pH. In organic synthesis, this property is often used to form carbon-oxygen bonds and synthesize complex organic molecules.
Furthermore, the pyridine ring has electron-rich properties. Due to the presence of nitrogen atoms, it can participate in the reaction as an electron donor. The pyridine ring of 4-methylpyridine-3-boronic acid can be complexed with metal ions to form stable complexes, which is widely used in the field of catalysis. After the metal complexes with the pyridine ring, it changes its own electron cloud density and spatial structure, which in turn affects the catalytic activity and selectivity.
In addition, 4-methylpyridine-3-boronic acid can also participate in the Suzuki-Miyaura coupling reaction. In this reaction, boric acid and organic halide are coupled with carbon-carbon bonds under the action of palladium catalyst and base to form biaryl or alkenylated products. This is an important method for constructing carbon-carbon bonds, which is of great significance in the fields of drug synthesis and materials science, and is helpful for the synthesis of organic compounds with diverse structures.
Due to the existence of pyridine ring and boric acid group, 4-methyl pyridine-3-boronic acid can perform nucleophilic substitution, electrophilic substitution and other reactions. Its methyl substituent also has a certain impact on the reactivity and selectivity, changing the molecular electron cloud distribution, regulating the reaction check point and rate.
In summary, 4-methyl pyridine-3-boronic acid has various chemical properties due to its unique structure, and has important application value in many fields such as organic synthesis, catalysis, materials and drug development.

4-Methylpyridine-3-boronic acid, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can be coupled with halogenated aromatics and olefins through the unique activity of carbon-boron bonds to create pyridine derivatives with diverse structures. Such derivatives are of great significance in the creation of medicine, or have pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor, which can help the development of new drugs.
In the field of materials science, 4-methylpyridine-3-boronic acid is also useful. It may participate in the preparation of functional materials and endow materials with specific optical and electrical properties. For example, by building conjugated systems with specific organic molecules to improve the photoelectric conversion efficiency of materials, it has made its mark in the fields of organic Light Emitting Diodes and solar cells.
In addition, in the field of catalytic chemistry, it can be used as a ligand to coordinate with metal ions to form high-efficiency catalysts. Such catalysts exhibit excellent catalytic activity and selectivity in many organic reactions, greatly improving reaction efficiency and product purity, which is of great benefit to the development of the chemical industry.

The synthesis of 4-methylpyridine-3-boronic acid is a key research direction in the field of organic synthesis. Traditional synthesis routes often use halogenated pyridine derivatives as starting materials. For example, 4-methyl-3-halogenated pyridine is first taken and reacted with metal reagents, such as butyllithium, in a low-temperature and inert gas-protected environment. The lithium atoms in butyllithium are active and can metallize with halogenated atoms to form lithium pyridine intermediates. This intermediate is highly active and then reacts with borates, such as trimethoxyborates, for nucleophilic substitution. After the reaction is completed, 4-methylpyridine-3-boronic acid can be obtained through the hydrolysis step.
Transition metal catalysis is also used. 4-methylpyridine is used as the starting material, and in the presence of suitable ligands and bases, it reacts with boron reagents, such as pinacol diborate, under the catalysis of transition metal catalysts, such as palladium catalysts. The palladium catalyst can activate the carbon-hydrogen bond at a specific position on the pyridine ring, so that the boron atom of the boron reagent is selectively added to the target position, and then the target product is generated. This method is relatively mild and highly selective, which can effectively avoid the occurrence of unnecessary side reactions.
In addition, 4-methylpyridine-3-boronic acid is synthesized by methylation reaction using pyridine-3-boronic acid as raw material. Using suitable methylation reagents, such as iodomethane, reacts with pyridine-3-boronic acid under the action of alkali, which can promote the formation of corresponding negative ions of pyridine-3-boronic acid, and then undergoes nucleophilic substitution reaction with iodomethane, and introduces methyl groups at the 4th position of the pyridine ring, and finally successfully obtains 4-methylpyridine-3-boronic acid.

4-Methylpyridine-3-boronic acid is a key reagent in organic synthesis. When storing and transporting this product, many matters need to be paid attention to.
First storage conditions. This substance is extremely sensitive to humidity and must be stored in a dry place. If placed in a humid environment, it is highly susceptible to moisture hydrolysis, causing its purity to decrease, which in turn affects the effectiveness of subsequent use. Therefore, it should be stored in a sealed container and placed in a dry and ventilated warehouse. The temperature should also be maintained relatively stable. It is usually best to refrigerate at 2-8 ° C to avoid large temperature fluctuations to prevent its chemical properties from being affected.
The second time is the transportation link. When transporting, it is necessary to ensure that the packaging is intact. This product is mostly contained in glass or plastic bottles, and the outside needs to be wrapped with a large amount of cushioning material to prevent the container from breaking due to collision during transportation. Due to its chemical properties, it should be transported separately from oxidants, acids, alkalis, etc., to prevent chemical reactions. The transportation vehicle should also be kept dry and clean, and no other chemical substances that may react with it should be left behind.
Furthermore, safety protection should not be underestimated. Whether it is storage or transportation personnel, they should be equipped with suitable protective equipment, such as protective gloves, goggles and protective clothing. If they accidentally come into contact with this substance, it may cause irritation to the skin and eyes. In the event of a leak, emergency measures should be taken immediately to collect the leak with inert adsorption materials to prevent it from spreading into the environment and causing pollution.
In summary, proper storage and safe transportation of 4-methylpyridine-3-boronic acid are essential to ensure its chemical stability and safe use. All aspects must be strictly controlled and must not be overlooked.

The market for 4-methylpyridine-3-boronic acid is often affected by various reasons. In the market for chemical raw materials, the price of this compound depends on its quality, supply and demand, ease of manufacture, and the batch size of transactions.
If its quality is good, high quality, etc., and the market demand is strong, then the supply is limited, and the price must be high. On the contrary, if the price is slightly low, and the market supply is abundant, the demand is not strong, the price may be slightly reduced.
Generally speaking, small batches are low, and the price per gram may be around 10 yuan to 100 yuan. However, if it is large-scale trading, in terms of kilograms, due to the efficiency of the model, the price per kilogram may be reduced to 10 thousand yuan.
For example, in the past, in the chemical industry, high-quality 4-methylpyridine-3-boronic acid was sold at a small retail price of 50 yuan per gram. However, if a one-time kilogram is sold, the supplier or supplier will receive a discount of 3,000 to 5,000 yuan per kilogram.
However, the chemical industry market is volatile, and the cost of raw materials, production, and shape can all make it fluctuate. In order to know the market situation, it is necessary to pay attention to the market situation and provide suppliers in order to obtain the latest and latest prices.