4-Methylpyridine-2-carbaldehyde

4-Methylpyridine-2-formaldehyde, this substance has a wide range of uses and is important in the field of chemical medicine.
In the chemical industry, it is often a key intermediate in organic synthesis. Due to its special structure, it has active aldehyde groups and pyridine rings, which can be derived from various high-value organic compounds through many chemical reactions. For example, by condensation with amine compounds, nitrogen-containing heterocyclic compounds can be prepared. Such compounds are widely used in dyes, fragrances and other industries, or can give dyes unique color and stability, and can also add special aroma to fragrances.
In the field of medicine, its status should not be underestimated. Many drug research and development use it as a starting material, and through a series of chemical modifications and reactions, drugs with specific pharmacological activities are prepared. For example, the synthesis of some anticancer drugs and antibacterial drugs, 4-methylpyridine-2-formaldehyde is often an important link. Because of its pyridine ring and aldehyde structure, it can interact with specific targets in organisms, or participate in the binding of drugs and receptors, thereby affecting the efficacy of drugs.
And because of its active chemical properties, compounds with diverse structures can be synthesized through different reaction paths, providing drug developers with rich structural templates to meet the treatment needs of different diseases, which is of great significance in the process of new drug creation.

4-Methylpyridine-2-formaldehyde is one of the organic compounds. It has many physical properties, let me tell you one by one.
Looking at its properties, 4-methylpyridine-2-formaldehyde is usually liquid at room temperature and pressure. Its color is mostly colorless to light yellow, and it has a special smell. This smell is quite unique and is one of the characteristics of this substance.
When it comes to the melting point, this substance has a low melting point, and the specific value is about -15 ° C. Due to its low melting point, it can also maintain a liquid state in a relatively low temperature environment.
In terms of boiling point, it is about 212-214 ° C. At this temperature, 4-methylpyridine-2-formaldehyde is converted from liquid to gaseous. This boiling point characteristic is crucial in separation, purification and other experiments and industrial operations.
In terms of solubility, 4-methylpyridine-2-formaldehyde is slightly soluble in water. Due to its molecular structure, although there are polar groups, the existence of pyridine rings and methyl groups limits its solubility in water. However, it is easily soluble in common organic solvents such as ethanol, ether, chloroform, etc. This solubility property makes it suitable for organic synthesis reactions, and the reaction environment can be prepared with different solvents. < Br >
The density is about 1.056g/cm ³, which is slightly heavier than water. When it comes to liquid-liquid separation or mixing operations, the density characteristics can be used to judge the stratification of liquids such as water.
The vapor pressure of 4-methylpyridine-2-formaldehyde is relatively low, indicating that its volatility is not very strong. This property can reduce the loss and harm caused by volatilization during storage and use.
In addition, the refractive index of this substance also has a specific value, about 1.537 - 1.541. Refractive index is an important parameter for identifying the purity and structure of organic compounds, and is of great significance in the field of analysis and detection.
To sum up, the physical properties of 4-methylpyridine-2-formaldehyde play an important role in organic chemistry research, chemical production and many other aspects, providing a lot of basis and convenience for related work.

4-Methylpyridine-2-carbalaldehyde, that is, 4-methylpyridine-2-formaldehyde, is a genus of organic compounds with unstable physical properties. Its molecule contains both a pyridine ring and an aldehyde group, and this unique structure causes it to have specific chemical activity.
The pyridine ring is aromatic, and the presence of nitrogen atoms gives it weak alkalinity, which can form salts with acids. The aldehyde group has high activity, and common reactions such as oxidation can be oxidized by mild oxidants, such as Torun reagent or Feilin reagent, to form carboxyl groups to obtain 4-methylpyridine-2-carboxylic acid; under the action of strong oxidants, the pyridine ring may also be affected.
In the reduction reaction, the aldehyde group can be reduced to an alcohol to obtain 4-methylpyridine-2-methanol. The aldehyde group can react with compounds containing active hydrogen, such as alcohols and amines. React with alcohols to form acetals; react with amines to form imine compounds.
Due to the interaction between the electronic effect of the pyridine ring and the aldehyde group, the chemical properties of 4-methylpyridine-2-formaldehyde are relatively active. It may oxidize slowly in the air. It should be kept in a cool and dry place to ensure its chemical stability. Safety should also be paid attention to during operation, because of its chemical activity or accidental reaction.

4-Methylpyridine-2-carbalaldehyde, that is, 4-methylpyridine-2-formaldehyde, has many synthesis methods, and each has its own advantages. First, 4-methylpyridine is used as the starting material and can be obtained by Vilsmeier-Haack reaction. In this reaction, 4-methylpyridine is co-heated with phosphorus oxychloride and N, N-dimethylformamide. Phosphorus oxychloride and N, N-dimethylformamide first form an active intermediate. The intermediate undergoes electrophilic substitution with 4-methylpyridine, and a formyl group is introduced at the 2-position of the pyridine ring to generate 4-methylpyridine-2-formaldehyde. This method route is relatively direct, and the raw materials are relatively easy to obtain. However, the reaction conditions need to be precisely controlled, and phosphorus oxychloride is highly corrosive. Caution is required during operation, and the post-reaction treatment is slightly cumbersome. Careful removal of residual phosphorus compounds is required.
Second, it is prepared by metal-catalyzed cross-coupling reaction. For example, a suitable halogenated 4-methylpyridine is reacted with a formylating agent under the action of a metal catalyst such as palladium or nickel. In this process, the metal catalyst activates the carbon-halogen bond of the halogenated pyridine, and the formylating agent is coupled with it to construct the target product. This method is highly selective and can effectively control the reaction check point. However, the cost of metal catalysts is quite high, and the reaction requires a strict anhydrous and anaerobic environment, which requires strict reaction equipment and operation.
Third, the oxidation reaction of pyridine derivatives is used. A specific 4-methylpyridine derivative is used as a substrate and oxidized by a suitable oxidant to convert a specific group into a formyl group. This approach requires the selection of appropriate oxidants and reaction conditions to ensure the stability of the pyridine ring and the yield of the target product. Different oxidants have a great impact on the reaction, and strong oxidants may over-oxidize and reduce the yield.
When synthesizing 4-methylpyridine-2-formaldehyde, the synthesis method should be reasonably selected according to the actual situation, considering factors such as raw material cost, reaction conditions, equipment requirements, and purity and yield of the target product.

4-Methylpyridine-2-carbalaldehyde, that is, 4-methylpyridine-2-formaldehyde, is in the market price range and often varies due to various factors.
The complexity of its preparation process, the difficulty of obtaining raw materials, and the fluctuation of market demand are all the keys to affecting its price. If the preparation method is cumbersome, the raw materials required are scarce and difficult to find, or the market demand for this product is strong, its price will be high; on the contrary, if the preparation is easier, the raw materials are sufficient, and the demand is normal, the price will be lower.
According to the past market view, its price often fluctuates from a few yuan to tens of yuan per gram. For high-purity products used in small-scale fine chemical experiments, the price may reach tens of yuan per gram due to strict quality requirements and high preparation costs. For lower-purity products used in industrial large-scale production, because they can be produced in batches, the cost is diluted, and the price per gram may only be a few yuan.
However, the chemical market is changing, and the price is also like a flowing stream, changing from time to time. To know the exact current price, you need to consult the relevant chemical raw material suppliers in detail, or check the latest quotations on the chemical product trading platform to get an accurate number.