4-Methyl-3-pyridinecarboxylic acid

4-Methyl-3-pyridinecarboxylic acid, which is an organic compound. Looking at its chemical properties, it has the characteristic of being acidic. Its structure contains a carboxyl group (-COOH), which can dissociate hydrogen ions (H 🥰) under suitable conditions, resulting in acidic properties.
Its acidity causes it to neutralize with alkali substances. If it encounters sodium hydroxide (NaOH), the hydrogen ion of the carboxyl group combines with the hydroxide ion (OH) to form water, resulting in the corresponding carboxylate and water. This reaction is such as: 4-methyl-3-pyridinecarboxylic acid + NaOH → 4-methyl-3-sodium pyridinecarboxylate + H2O O. < Br >
Furthermore, the pyridine ring of this compound is aromatic. Because the pyridine ring satisfies the Shocker rule, there is a closed conjugate system and 6 π electrons, which makes its chemical properties stable to a certain extent, and the nitrogen atom of the pyridine ring has a certain alkalinity, which can be combined with acids to form salts.
And because of the presence of methyl (-CH 🥰), it affects the electron cloud distribution of the molecule, or causes changes in the activity of electrophilic substitution reaction. Methyl as the power supply group can increase the density of electron clouds in the adjacent and para-sites of the pyridine ring. During the electrophilic substitution reaction, the electrophilic reagents may be more likely to attack the adjacent and para-sites.
In summary, 4-methyl-3-pyridinecarboxylic acid has both the acidic properties of carboxyl groups and the related chemical properties of pyridine rings, which make it have important uses in many fields such as organic synthesis and medicinal chemistry.

4-Methyl-3-pyridinecarboxylic acid, also known as isonicotinic acid, is synthesized by the following methods:
First, 4-methylpyridine is used as the starting material and prepared by oxidation reaction. In a suitable reaction vessel, add 4-methylpyridine, an appropriate amount of catalyst, such as potassium permanganate or potassium dichromate and other strong oxidants, and then add an appropriate amount of solvent, such as sulfuric acid aqueous solution. The temperature is controlled within a certain range, usually heated to 50-80 ° C, and the reaction is carried out for several hours. During this process, the methyl group of 4-methylpyridine is oxidized to a carboxyl group to form 4-methyl-3-pyridinecarboxylic acid. After the reaction is completed, the pure product can be obtained by cooling, filtration, washing, crystallization and other steps.
Second, hydrolysis is carried out with 3-cyano-4-methylpyridine as raw material. Take 3-cyano-4-methylpyridine and place it in the reactor, add an appropriate amount of acid or base as a catalyst. If acid catalysis is used, sulfuric acid or hydrochloric acid can be selected; if alkali catalysis is used, sodium hydroxide or potassium hydroxide can be used. Add an appropriate amount of water, heat it to a suitable temperature, usually 80-120 ° C, and react for several hours. The cyanyl group is hydrolyzed under the action of acid or base and converted into carboxyl group to obtain 4-methyl-3-pyridinecarboxylic acid. After the reaction, the target product is obtained through neutralization, separation, purification and other steps.
Third, 4-methyl-3-pyridineformaldehyde is used as raw material and synthesized by oxidation reaction. 4-methyl-3-pyridineformaldehyde and suitable oxidants, such as manganese dioxide or hydrogen peroxide, are placed in the reaction system, an appropriate amount of solvent and catalyst are added, and the reaction temperature is controlled at 20-60 ° C for several hours. The aldehyde group of 4-methyl-3-pyridyl formaldehyde is oxidized to carboxyl group to produce 4-methyl-3-pyridyl carboxylic acid. After subsequent separation and purification operations, the product with high purity is obtained.
These synthetic methods have their own advantages and disadvantages. In practical application, the appropriate method should be selected according to the comprehensive consideration of factors such as the availability of raw materials, cost, and reaction conditions.

4-Methyl-3-pyridinecarboxylic acid, also known as isonicotinic acid derivatives, is useful in various fields.
In the field of medicine, its use is quite critical. The structure of geiinecarboxylic acid can participate in the construction of drug molecules, and it can be used as a base to make good drugs against infections. Its chemical properties help drugs bind precisely to pathogens, or break their cell walls, or disrupt their metabolic pathways, thus achieving antibacterial effects. Furthermore, in the development of anti-tumor drugs, 4-methyl-3-pyridinecarboxylic acid can be used as a key intermediate. After ingenious chemical modification, it may be able to fit with specific targets of cancer cells, block their proliferation, induce apoptosis, and add a new path to anti-cancer therapy.
In the field of materials science, it can also be seen. It can be introduced into polymer. Due to the conjugated structure of the pyridine ring, the material has unique electrical and optical properties. For example, 4-methyl-3-pyridinecarboxylic acid can be used as a dopant or structural unit to regulate the conductivity of the polymer. It is very useful in electronic devices such as organic Light Emitting Diodes and solar cells to improve the photoelectric conversion efficiency and stability of the device.
In the field of agriculture, its role cannot be ignored. Pesticides can be prepared by chemical transformation. Pyridinecarboxylic acid derivatives may have the ability to repel and poison pests, and due to structural characteristics, some products are environmentally friendly, easy to degrade in the natural environment, reduce pollution residues, and provide ideas for the creation of green pesticides.
In the field of chemical synthesis, 4-methyl-3-pyridinecarboxylic acid is an important building block for organic synthesis. Because of its carboxyl group and methyl, pyridine ring can undergo a variety of chemical reactions, such as esterification, acylation, alkylation, etc., which can build complex organic molecular structures, lay the foundation for the synthesis of new compounds, and promote the development of organic synthesis chemistry.

Today there is a question: What is the market price of 4 - Methyl - 3 - pyridinecarboxylic acid? This is a product in the field of organic chemistry, named 4 - Methyl - 3 - Pyridinecarboxylic acid, also known as 4 - Methyl Nicotinic Acid. The price varies greatly depending on the quality, purity, manufacturer, and market supply and demand.
If you ask for it in the chemical raw material market, the purity is normal, and the price may be relatively easy. However, if you need high purity, such as for special fields such as pharmaceuticals and fine chemicals, because of its difficult preparation and strict process requirements, the price will be high.
Looking at the past market, in the chemical raw material distribution center, common purity specifications, when purchasing in bulk, the price per kilogram may be hundreds of yuan. However, in the experimental reagent market, the price per gram of small packages and high purity products may reach several yuan or even tens of yuan.
And due to market fluctuations, the cost of raw materials, production process innovation, and the impact of policies and regulations can all cause their prices to fluctuate. To know the exact price, you need to consult chemical product suppliers, reagent dealers, or check recent quotations on the chemical product trading platform to get the current accurate price.

4-Methyl-3-pyridinecarboxylic acid, that is, 4-methyl-3-pyridinecarboxylic acid, its storage conditions are very critical. This substance should be stored in a cool, dry and well-ventilated place.
A cool environment can avoid changes in its properties due to high temperature. High temperature can easily cause changes in the internal structure of the compound, or cause undesirable conditions such as decomposition, which can damage its quality and purity.
The place where it dries is due to the strong influence of moisture. Moisture can easily cause it to absorb moisture, or cause deliquescence, which in turn affects its chemical properties, or promotes the formation of impurities.
Well ventilated can ensure air circulation, reduce the accumulation of harmful gases or water vapor in the environment, and maintain a stable storage environment to avoid reactions with substances in the environment.
In addition, it should be placed in a sealed container. Sealing can effectively isolate external air, water vapor and other impurities, and prevent oxidation, hydrolysis and other reactions. And keep away from fire sources, heat sources and strong oxidants. Because of its certain chemical activity, it will seriously endanger safety in case of fire sources, heat sources or strong oxidants, or cause danger such as combustion and explosion. Proper storage of 4-methyl-3-pyridinecarboxylic acid can ensure its chemical stability and reliable quality.