4-Methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

4 - Methyl - 2 - oxo - 1,2 - dihydropyridine - 3 - carbonitrile is an organic compound. According to its name, its structure can be deduced according to the naming rules of organic chemistry.
"pyridine" is a pyridine, a nitrogen-containing hexaherocyclic compound. "1,2 - dihydro -" means hydrogenation at the 1st and 2nd positions of the pyridine ring, so that the original double bond between the 1st and 2nd positions in the pyridine ring becomes a single bond. " 2-Oxo - "means that the 2-position has a carbonyl group (C = O)," 3-carbonitrile "indicates that the 3-position has a cyano group (-CN), and" 4-Methyl "indicates the presence of a methyl group (-CH 🥰) at the 4-position.
Its chemical formula may be written as C H N ² O. In the structure, the pyridine ring is hydrogenated at 1 and 2 positions, and there are two less unsaturation degrees. The 2-position carbonyl group accounts for one unsaturation each with the 3-position cyano group and the 4-position methyl group. This compound has a unique structure. The nitrogen-containing heterocyclic ring is connected to a variety of functional groups, and these functional groups interact with each other, giving it unique chemical properties. Carbonyl groups are electrophilic, cyano groups can participate in various reactions, and methyl groups affect the molecular spatial structure and electron cloud distribution. This structure may have important applications in organic synthesis, medicinal chemistry and other fields, and can be used as an intermediate to construct more complex organic molecules.

4-Methyl-2-oxo-1,2-dihydropyridine-3-formonitrile, which has a wide range of uses. In the field of medicine, it is often used as a key intermediate. Due to its unique structure, it can build complex drug molecular structures through various chemical reactions, providing a cornerstone for the creation of new drugs. For example, in the synthesis of some cardiovascular disease treatment drugs, it plays an indispensable role in the synthesis of compounds with specific physiological activities.
It also plays an important role in pesticides. Using this as a raw material, high-efficiency, low-toxicity and environmentally friendly pesticides can be prepared. The pesticides it participates in the synthesis can effectively kill pests, inhibit the growth of pathogens, ensure the robust growth of crops, and improve agricultural yield and quality.
In the field of materials science, 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile also shows potential uses. Or it can be used to prepare polymer materials with special properties, such as materials with excellent optical and electrical properties, which contribute to the development of electronic devices, optical instruments and other fields. In addition, in the study of organic synthetic chemistry, it serves as an important synthetic building block for chemists to design and synthesize various novel organic compounds, promoting the continuous development of organic synthetic chemistry and expanding the boundaries of human understanding of the structure and properties of organic compounds.

The synthesis method of 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile is an important topic in the field of organic synthesis. Common synthesis methods include the following.
First, ethyl acetoacetate and malononitrile are used as starting materials. In a suitable solvent, the condensation reaction of the two occurs under the catalysis of a base. The base can be selected from sodium alcohol or the like, and the solvent such as ethanol. During this reaction, the carbonyl group of ethyl acetoacetate interacts with the active methylene of malonitrile to form a key intermediate. Subsequently, the intermediate is cyclized to form a pyridine ring structure. This cyclization step may require a specific temperature and reaction time to obtain a higher yield product.
Second, 4-methylpyridine is used as the starting material. First, 4-methylpyridine is oxidized, so that the nitrogen atom ortho-site on the pyridine ring is introduced into the carbonyl group to form 4-methyl-2-pyridinone intermediates. This oxidation process may require the selection of suitable oxidants, such as potassium permanganate, etc. After that, the 3-position of the intermediate is cyanylated. The cyanylation reagent can be selected from potassium cyanide, etc. Under appropriate reaction conditions, the cyanyl group is introduced at the 3-position to obtain the target product 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile.
Third, the isonicotinic acid derivative is used as the starting material. By specific conversion of the carboxyl group of the isonicotinic acid derivative, such as first conversion to acyl chloride, and then reaction with nitrogen-containing nucleophiles, the partial structure of the pyridine ring is formed. Subsequently, the specific position on the pyridine ring is modified by methylation and cyanylation, and the synthesis of 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile can also be achieved through multi-step reactions.
Each synthesis method has its own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of controlling reaction conditions, the purity and yield of the product, and choose the most suitable synthesis path.

4-Methyl-2-oxo-1,2-dihydropyridine-3-formonitrile is an organic compound. Its physical properties are quite important, and it is related to its behavior in various chemical processes and applications.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. Due to the strong intermolecular force, the particles formed by it are arranged in an orderly manner and exist in a solid state. Its color is often white to off-white, and this pure color can be used as the basis for identification and purity determination.
The melting point has been determined by many experiments to be within a certain temperature range. Melting point is the critical temperature at which the compound changes from solid to liquid state. This value is specific and repeatable, because the molecular structure of the compound is fixed. The melting point of 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile is a key indicator when it is isolated, purified and identified.
As for solubility, this compound exhibits specific solubility properties in organic solvents. Common organic solvents such as ethanol and acetone are soluble. Due to the interaction between the compound molecules and organic solvent molecules, such as hydrogen bonds and van der Waals forces, it can be dispersed in solvents. However, in water, the solubility is poor. Due to the fact that there are many hydrophobic parts in its molecular structure, the interaction with water molecules is weak, and it is difficult to dissolve with water.
Furthermore, its density is also one of the physical properties. Density reflects the mass of the substance per unit volume, and the density of 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile is specific. This value is indispensable in chemical operations such as material measurement and reaction system formulation, and is related to reaction accuracy and product quality.
The physical properties of this compound are of great significance in chemical synthesis, drug research and development, materials science and other fields, laying the foundation for related research and applications.

4-Methyl-2-oxo-1,2-dihydropyridine-3-formonitrile, this is an organic compound that has applications in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. The synthesis of many drugs depends on its construction of a specific pyridine structure. For example, when developing drugs for the treatment of cardiovascular diseases, the pyridine ring structure of the compound can be modified and modified to meet the needs of the drug and the target, or to affect the activity, selectivity and pharmacokinetic properties of the drug molecule.
In the field of materials science, it may be used to synthesize functional materials. Due to the fact that the pyridine ring imparts certain electronic properties and structural stability, when preparing materials with special optical and electrical properties, 4-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile can be introduced as a structural unit, thus endowing the material with unique properties, such as preparing organic optoelectronic materials, improving its charge transport ability or luminous efficiency.
In the field of organic synthetic chemistry, it is an important type of synthetic building block. With its active functional groups such as nitrile and carbonyl groups, it can participate in a variety of organic reactions, such as nucleophilic addition, cyclization, etc., for the construction of more complex organic molecular structures, providing a wealth of strategies and possibilities for organic synthesis chemists to assist in the creation and development of new organic compounds.