4-methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine

4 - methyl - 2 - (1,1,1 - trifluoro - 2 - methylpropan - 2 - yl) pyridine is an organic compound. Looking at its structure, the pyridine ring is matched with specific substituents and has many applications in the fields of organic synthesis and medicinal chemistry.
In the field of organic synthesis, it can be used as a key intermediate. The nitrogen atom of the pyridine ring has unique electronic properties. It can introduce other functional groups through nucleophilic substitution, electrophilic substitution and other reactions to expand the structural diversity of the compound. Taking nucleophilic substitution as an example, nitrogen atoms can attract nucleophilic reagents, causing reactions to occur at specific locations, building more complex organic molecular structures, and assisting chemists in creating new materials or organic compounds with specific functions.
In the field of medicinal chemistry, such fluoropyridine derivatives often have unique biological activities. The introduction of fluorine atoms can change the lipid solubility and metabolic stability of compounds. Because biological membranes are composed of lipids, lipid-soluble compounds are easier to penetrate cell membranes and reach their targets. And fluorine atoms can enhance the stability of molecules, reduce the metabolic rate, and prolong the action time of drugs in the body. Therefore, 4 - methyl - 2 - (1,1,1 - trifluoro - 2 - methylpropan - 2 - yl) pyridine may become an important starting material for the development of new drugs for medical researchers to explore its potential in the treatment of diseases, such as anti-cancer, anti-infection drug development.

4-Methyl-2 - (1,1,1-trifluoro-2-methylpropane-2-yl) pyridine, which is an organic compound. Its molecular structure, containing a pyridine ring, is connected with a methyl group at the 4th position of the pyridine ring, and a 1,1,1-trifluoro-2-methylpropane-2-yl at the 2nd position. Its physical properties are as follows:
- ** Physical state and color **: Under normal circumstances, it may be a colorless to light yellow liquid, but it also varies slightly due to purity and environmental factors. Pure products are mostly colorless and transparent. If they contain impurities, the color may be slightly yellowish.
- ** Odor **: It has a special organic smell. This smell may be irritating to a certain extent, but it is not extremely pungent. It is similar to the smell of common pyridine compounds. However, it is slightly different due to the substituent.
- ** Melting Point and Boiling Point **: Due to the introduction of fluorine atoms in the molecule, its melting point and boiling point are affected. Trifluoromethyl has strong electron absorption, which changes the intermolecular force. Its boiling point may be within a certain range due to relative molecular mass and intermolecular forces. It is roughly speculated that the boiling point may be between 150 and 200 ° C. The melting point may be lower or in the range of -20 to 0 ° C. The specific value needs to be accurately determined by experiments.
- ** Solubility **: In view of the fact that the pyridine ring has a certain polarity and there are groups such as methyl in the molecule, it has good solubility in organic solvents. Such as soluble in common organic solvents such as ethanol, ether, and dichloromethane. However, due to the hydrophobicity of trifluoromethyl, its solubility in water is poor, only slightly soluble or insoluble. < Br > - ** Density **: The fluorine atoms in the molecule have a large relative atomic mass, which makes the molecular density higher than that of ordinary hydrocarbons, or between 1.2 and 1.4 g/cm ³. However, the exact value depends on the experimental measurement.

4 - methyl - 2 - (1,1,1 - trifluoro - 2 - methylpropan - 2 - yl) pyridine is an organic compound with unique chemical properties. In this substance, the presence of the pyridine ring gives it a certain alkalinity, and the nitrogen atom of the pyridine ring has unshared electron pairs and can accept protons.
The 4 - methyl group in the molecule, because the methyl group is the power supply group, can affect the electron cloud density of the pyridine ring, causing the electron cloud density on the ring to increase, in the electrophilic substitution reaction, or has an effect on the reaction check point and activity. For example, electrophilic reagents or more likely to attack areas with higher electron cloud density.
And the 2- (1,1,1-trifluoro-2-methylpropyl-2-yl) part contains trifluoromethyl, which has strong electron-withdrawing properties. This strong electron-withdrawing group can increase the polarity of the molecule, and produce a pulling electron effect on the electron cloud of the pyridine ring, which checks and balances the interaction with the methyl power supply, further affecting the reactivity and selectivity of the compound.
In terms of solubility, the molecule has both hydrophobic alkyl groups and polar pyridine rings, and may have certain solubility in organic solvents. In chemical reactions, it can participate in acid-base reactions due to the alkalinity of the pyridine ring, and can also involve nucleophilic and electrophilic reactions due to the characteristics of each group. Its chemical properties are complex, and the interaction of each group determines its behavior in different chemical environments.

To prepare 4 - methyl - 2 - (1,1,1 - trifluoro - 2 - methylpropan - 2 - yl) pyridine, there are various methods. Common methods, or start with suitable pyridine derivatives, by means of nucleophilic substitution, introduce trifluoromethyl groups.
If 4 - methyl pyridine is used as the starting material, it can first react with strong bases, such as n-butyl lithium, to generate carbon anions at the 2 - position of pyridine. This negative carbon ion is highly reactive and can undergo nucleophilic substitution reaction with 1,1,1-trifluoro-2-methyl-2-halopropane (such as chloro and bromo). In this process, the halogen atom leaves, and a new bond is formed between the 2-position of pyridine and the hydrocarbon group containing trifluoromethyl, and the target product is obtained.
Or starting from 2-halo-4-methyl pyridine, metallization-nucleophilic substitution reaction is carried out with metal-organic reagents, such as trifluoromethyl zinc reagents. First, the halogen atom interacts with the metal to form an organometallic intermediate, and then partially couples with the trifluoromethyl in the trifluoromethyl zinc reagent, which can also achieve the purpose of preparation.
During the preparation process, attention should be paid to the control of the reaction conditions. Temperature, solvent, and the proportion of reactants are all key. The reaction of nucleophilic substitution needs to be carried out in an environment protected by anhydrous and inert gases to avoid side reactions. The choice of solvent depends on the nature of the reactants and intermediates, such as tetrahydrofuran, N, N-dimethylformamide, etc., which are often suitable solvents.
Furthermore, the proportion of reactants should not be underestimated. In order to obtain a high yield product, the proportion of reactants should be appropriate. Excessive amounts of a reactant may help the reaction proceed towards the formation of the target product, but also need to weigh the cost and the difficulty of subsequent separation.
In short, the preparation of 4-methyl-2- (1,1,1-trifluoro-2-methylpropan-2-yl) pyridine can be selected according to the availability of raw materials and the feasibility of reaction conditions.

I don't know if 4 - methyl - 2 - (1,1,1 - trifluoro - 2 - methylpropan - 2 - yl) pyridine is in the market price range. This compound may be a specific organic synthesis intermediate or a chemical with special purposes, and its price is affected by many factors.
First, the difficulty of preparation matters a lot. If the synthesis requires complicated steps, harsh reaction conditions, or the use of rare and expensive starting materials and reagents, the cost will rise and the price will also be high. If the synthesis requires multiple steps and the yield of each step is not high, or the reaction equipment is extremely demanding, the cost will rise.
Second, the amount of market demand is also the key. If there is a strong demand for this product in a certain field, such as a specific stage of pharmaceutical research and development or a special application of materials science, and the supply is limited, according to the law of supply and demand, the price must be high; conversely, if the demand is small, the price may be relatively low.
Third, the supply situation has a great impact. If only a few manufacturers can produce, the monopoly or oligopoly situation will make the price more manipulative and tend to be high; if there are many manufacturers, the competition is fierce, and the price may be reduced due to competition.
Fourth, the purity requirements affect the price. High-purity products require finer purification processes, the cost increases, and the price is higher than that of low-purity products.
However, I have checked the books I know, but I have not obtained the exact price range. For details, you can consult chemical product suppliers, chemical trading platforms, or find them in chemical industry information and market survey reports to get the exact price range.