4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

4-Methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile is an organic compound. Its main uses are quite extensive, and it is often used as a key intermediate in the field of medicinal chemistry. Geinpyridine compounds have a variety of biological activities, from which many substances with specific pharmacological activities can be derived, or used to develop new drugs, such as the creation of antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials science, it also has its uses. It can be introduced into the structure of polymer materials through specific reactions, which can then change the properties of materials, such as improving the stability and optical properties of materials. Because it contains functional groups that can react with other substances, it provides a way for material modification.
In the field of organic synthesis, it is also an important synthetic building block. With its unique molecular structure and reactivity, it can participate in many organic reactions, such as nucleophilic substitution, cyclization, etc., helping to construct more complex organic molecular structures, laying the foundation for the synthesis of novel organic compounds, which is of great significance in the research and practical production of organic synthesis chemistry.

The synthesis method of 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile is an important research direction in the field of organic synthesis. There are various synthetic routes, and the common ones are as follows.
First, the compound containing the pyridine ring is used as the starting material. A specific substituted pyridine derivative can be selected, and methoxy and cyano are introduced under suitable reaction conditions. For example, a certain type of pyridine is used as the substrate first, and under the catalytic action of a base, the nucleophilic substitution reaction occurs with the halogenated methoxy reagent, and then the methoxy group is introduced at the specific position of the pyridine ring. Then, through a specific oxidation or substitution step, a cyanyl group is introduced at another position. In this process, the reaction temperature, time and reagent dosage need to be precisely controlled to achieve the ideal reaction yield and selectivity.
Second, through the strategy of constructing a pyridine ring. A multi-component reaction can be used, using compounds containing carbonyl groups, nitrile groups and methoxy groups as raw materials, and under the action of catalysts, the target product can be formed through cyclization. For example, using ethyl acetoacetate, methoxylamine hydrochloride and cyanoacetamide as starting materials, in an acidic or basic catalytic environment, after a series of reactions such as condensation and cyclization, the pyridine ring structure is gradually constructed, resulting in 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile. The advantage of this method is that complex pyridine ring structures can be constructed in one step, which is relatively simple to operate, but the requirements for reaction conditions are also stricter. Different catalysts and reaction solvents have a great impact on the reaction results.
Third, transition metal catalysis can also be used for the reaction. Transition metals such as palladium and copper are used as catalysts to promote the coupling reaction between substrates with their unique catalytic activities. For example, selecting suitable halogenated pyridine derivatives and reagents containing methoxy and cyanyl groups, under the synergistic action of transition metal catalysts and ligands, the formation of carbon-carbon, carbon-nitrogen and other bonds is achieved, so as to synthesize the target product. This method has relatively mild reaction conditions and high selectivity, but the cost of transition metal catalysts is high, and the separation and recovery of the catalyst after the reaction also need to be considered.
There are many methods for the synthesis of 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile, each with its own advantages and disadvantages. In practical applications, the appropriate synthesis method should be carefully selected according to the availability of raw materials, reaction cost, purity requirements of target products and many other factors.

4-Methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile is an organic compound. Its physical properties are as follows:
Looking at its properties, it may be solid at room temperature and pressure, but it also changes depending on its purity and surrounding environment. Its color may be colorless to light yellow, or it may be different due to the mixing of impurities.
As for the melting point, due to the interaction within the molecular structure, including hydrogen bonds, van der Waals forces, etc., the molecules are arranged in an orderly manner, giving them a specific melting point. Although exact data are rarely available, the melting point of such compounds containing nitrogen heterocycles with nitrile groups and methoxy groups is usually within a moderate range, or between tens of degrees Celsius and hundreds of degrees Celsius.
In terms of solubility, in view of the hydrophilicity of nitrile groups, methoxy groups also interact with water to a certain extent, while pyridine rings have certain hydrophobicity, so they may have a certain solubility in water, but not very high. Organic solvents such as ethanol and acetone can form a similar compatibility with these compounds, so their solubility in such organic solvents may be better.
Its density is also closely related to its molecular weight and molecular accumulation. According to its structure, the density may be similar to that of common organic compounds, but the exact value still needs to be determined experimentally and accurately.
Volatility is relatively low, because of the strong intermolecular force, and the high energy required for molecules to escape from the liquid phase to the gas phase, which is also consistent with its solid or liquid state at room temperature.
In summary, the physical properties of 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile are determined by their unique molecular structure, and may change subtly under different conditions. Many properties need to be investigated experimentally.

4-Methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile, this is an organic compound. Its chemical properties are unique and contain multiple interesting properties.
Let's talk about the nitrile group (-CN) it contains first, which has high reactivity. Nitrile groups can be hydrolyzed, and can be gradually converted into amides under acid or base catalysis conditions, and then become carboxylic acids. For example, in an alkaline environment, when heated with water, the cyano group is first converted into an amide group, and the continuous reaction is a carboxylate, and the corresponding carboxylic acid can be obtained after acidification. This property is crucial in the preparation of carboxyl-containing compounds in organic synthesis.
Furthermore, the carbonyl group (C = O) in the molecule is also extremely active. Carbonyl carbons are electrophilic and vulnerable to attack by nucleophiles. For example, Grignard reagents (RMgX) can react with the carbonyl group to generate alcohol derivatives. This reaction provides an effective way to construct carbon-carbon bonds, which is of great significance for the construction of complex organic molecules.
Although methoxy (-OCH 🥰) is relatively stable, it has an impact on the distribution of molecular electron clouds. Methoxy is a power supply group, which can increase the electron cloud density on the pyridine ring through conjugation effect, affecting the reactivity and selectivity of the pyridine ring. In the electrophilic substitution reaction, methoxy group will make the reaction more likely to occur in its adjacent and para-position.
The dihydropyridine structure of this compound also has certain stability and special reactivity. Some dihydropyridine compounds exhibit biological activities, such as some with calcium channel blocking effect, which are used in the treatment of cardiovascular diseases. 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile Although this kind of biological activity is not clear, it may have potential exploration value in the field of drug development due to its similar structure.

Today there is 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile. I don't know what the price is in the market. To know its price, you can visit the chemical materials market. This compound, or commonly found in chemical raw materials, if you want to find its price, you should look for a merchant specializing in chemical products.
In the past, I have never heard of this name in "Tiangong Kaiwu". The records in "Tiangong Kaiwu" are mostly related to ancient craftsmanship, agricultural mulberry weaving, hardware metallurgical casting, etc. At that time, the art of chemistry was not as prosperous as it is today, and there was no such fine synthesis.
In today's world, the chemical industry is prosperous. This 4-methoxy-2-oxo-1,2-dihydropyridine-3-formonitrile may be used in pharmaceutical synthesis, organic chemical industry, etc. To know its market price, you can find it on the chemical trading platform, or ask the supplier of chemical raw materials. The price may vary depending on the quality, purity, supply and demand, and it cannot be determined in one word. Or you can visit the merchants and compare them in detail to know the approximate price.