4-(m-tolylamino)pyridine-3-sulfonamide

The chemical structure of 4 - (m-toluenyl) pyridine-3 -sulfonamide is quite elegant. Looking at its name, the approximate structure can be analyzed.
This compound uses pyridine as the core parent ring. Pyridine is an organic compound containing a nitrogen six-membered heterocyclic ring with unique properties. At the 3rd position of the pyridine ring, there is a sulfonamide group connected. Sulfonamide group is formed by linking the sulfonyl group to the amino group, and the structure of -SO 2O NH 2O is also. This group imparts specific chemical and physical properties to the compound, and plays an important role in many reactions and biological activities.
And at the 4th position of the pyridine ring, it is connected to the m-toluenyl amino group. M-toluenyl, which is the methyl substituent in the interposition of the benzene ring of toluene, is then connected with the amino group to form the m-toluenamino group. The introduction of this substituent also has a great impact on the overall properties of the compound due to the influence of the electron effect and steric hindrance of methyl groups. Methyl groups can change the electron cloud density distribution of molecules, which in turn affects their reactivity and stability; steric hindrance may affect the intermolecular interactions and stereochemical properties.
In summary, the chemical structure of 4- (m-toluenamido) pyridine-3-sulfonamide, with the pyridine ring as the core, and the 3-position sulfonamido group and the 4-position m-toluenamido group, interact with each part, which together determine the unique properties and reactivity of

4- (m-toluenyl) pyridine-3-sulfonamide, this substance has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate for the synthesis of many specific drugs. If antibacterial drugs are created, they are integrated into the molecular structure of the drug through specific chemical reactions, giving the drug excellent antibacterial activity, which can effectively resist the invasion of specific pathogens into the human body, and make outstanding contributions to the treatment of infectious diseases.
In the field of materials science, it also has outstanding performance. It can be used as an important component of functional materials and added to specific material systems through special processing. In this way, the material properties can be significantly improved, such as improving the stability of the material, so that it can maintain its inherent properties under different environmental conditions, and does not easily undergo qualitative changes. It has great potential for application in electronic devices, polymer materials and other fields.
Furthermore, in the field of agricultural chemistry, 4- (m-toluenylamino) pyridine-3-sulfonamide has also emerged. It can be used as a basic raw material for the development of new pesticides. Through rational design and synthesis, pesticide products with high insecticidal and bactericidal properties can be made. Such pesticides have significant effect on the control of common diseases and pests of crops, and are relatively friendly to the environment. They can help the green and sustainable development of agriculture and make great contributions to ensuring crop yield and quality.

4- (m-toluenyl) pyridine-3-sulfonamide is a kind of organic compound. Its physical properties are of great research value, and I will describe them in detail for you.
Looking at its properties, it is often in a solid state at room temperature and pressure. Most of them are in powder form, which is easy to store and use, and is also conducive to subsequent chemical reactions. Its color is mostly white to off-white, and its color is pure, reflecting its high purity and relatively single chemical structure.
When it comes to solubility, this compound exhibits certain solubility properties in organic solvents. Such as common methanol and ethanol, can partially dissolve 4- (m-toluene amino) pyridine-3-sulfonamide. This dissolution phenomenon is due to the interaction between the compound molecule and the organic solvent molecule, such as van der Waals force, hydrogen bond, etc. In polar organic solvents, its solubility is slightly better, because the compound itself also has a certain polarity. However, in water, its solubility is relatively low, because the polarity of water and the polarity of the compound are limited, and the interaction force between the compound molecules also hinders its dissolution in water.
Melting point is an important indicator to measure the physical properties of the compound. It has been experimentally determined that 4- (m-toluenyl) pyridine-3-sulfonamide has a specific melting point range. The existence of this melting point indicates that the lattice structure of the compound molecules changes during heating, from a solid-state ordered arrangement to a liquid-state disordered state. Accurate determination of the melting point not only helps to identify the purity of the compound, but also provides key parameters for its synthesis, separation and purification.
In addition, the density of the compound is also one of its physical properties. Although the determination of the density value requires precise instruments and rigorous operation, it is of great significance for studying the microstructural information such as the accumulation mode and the distance between molecules of the compound. Through the density data, the compactness of the compound molecules in the solid state can be inferred, which provides strong support for the study of the correlation between its physical and chemical properties.
In summary, the physical properties of 4 - (m-toluenyl) pyridine-3 - sulfonamide, including properties, solubility, melting point and density, lay a solid foundation for in-depth understanding of the properties and applications of the compound.

To prepare 4- (m-toluenyl) pyridine-3-sulfonamide, the following method can be followed.
The first pyridine-3-sulfonyl chloride is taken as the starting material, which is the key thing. When adding m-toluidine slowly into the reaction system of pyridine-3-sulfonyl chloride, it must be noted that when adding it, the rate is moderate and not too hasty. When the two meet, a nucleophilic substitution reaction occurs.
The reaction environment is quite important, and organic solvents are often used as the medium, such as dichloromethane, N, N-dimethylformamide, etc. Such solvents can uniformly disperse the reactants and facilitate their contact and reaction. And during the reaction, the temperature also needs to be finely regulated, generally maintained at a low temperature, such as between 0 ° C and 5 ° C, to prevent the growth of side reactions.
When the reaction begins, the amino group of m-toluidine, with its electron-rich properties, nucleophilically attacks the sulfonyl carbon of pyridine-3-sulfonyl chloride, and the chlorine leaves the atom, then becomes the initial product of 4- (m-toluenyl) pyridine-3-sulfonamide.
However, the product may contain unreacted raw materials or impurities generated by side reactions. Therefore, it needs to be separated and purified. Column chromatography can be used to select appropriate stationary and mobile phases to effectively separate the product from the impurities. Or use the method of recrystallization, select a suitable solvent, and use the different solubility of the product and impurities at different temperatures to achieve the purpose of purification. In this way, pure 4- (m-toluenyl) pyridine-3-sulfonamide can be obtained.

4 - (m-toluenamido) pyridine-3 - sulfonamide is a chemical substance. When using it, many matters must be paid attention to.
Bear the brunt of it, and it is safe to be heavy. This substance may be toxic and irritating, and protective gear is indispensable when operating. Wear protective clothing, protective gloves and goggles to prevent it from touching the skin and eyes and causing damage. In case of inadvertent contact, rinse with plenty of water as soon as possible. If the situation is serious, seek medical attention urgently.
Furthermore, accurate weighing and use are crucial. Due to its special nature, the dosage varies, or the reaction results are very different. Therefore, it is necessary to borrow precise measuring tools according to the exact requirements of the experiment or production, and use them according to the amount. Do not increase or decrease at will.
The method of storage should not be underestimated. It should be placed in a dry, cool and well-ventilated place, away from fire sources and oxidants. Improper storage may cause it to deteriorate, affect performance, and even cause safety risks.
In addition, the use environment should be well ventilated. During operation, there may be volatile gas, which can be dispersed in time to prevent it from accumulating in the air and endangering human health.
Repeat, it is extremely important to understand its chemical properties and reaction characteristics. Know what kind of substances it can react with and what the reaction conditions are, so that the use steps can be reasonably planned to prevent accidental reactions.
At the end of the day, after use, properly dispose of the remaining materials and waste. It should not be discarded at will, and should be disposed of in accordance with relevant regulations to prevent pollution to the environment.