4-Iodo-pyridine-2-carboxylic acid

4-Iodopyridine-2-carboxylic acid, this is an organic compound. Its physical properties are mostly solid at room temperature, with white to light yellow powder in color and little odor. The melting point is about a specific range, but the exact value varies slightly due to different experimental conditions.
Chemical properties, the compound contains carboxyl groups and iodine atoms, and the carboxyl groups are acidic, which can neutralize with bases to generate corresponding carboxylate and water. For example, by reacting with sodium hydroxide, 4-iodopyridine-2-carboxylate sodium and water are obtained.
Iodine atoms are active and can participate in many nucleophilic substitution reactions. For example, under suitable catalysts and reaction conditions, it can be replaced by other nucleophiles, such as amino and hydroxyl substitutions, to construct new compounds with different structures.
The pyridine ring of 4-iodopyridine-2-carboxylic acid is aromatic and can carry out aromatic electrophilic substitution reaction. Because the carboxyl group and the iodine atom are electron-absorbing groups, the electron cloud density of the pyridine ring is reduced, and the reaction activity is different from that of benzene. Substitution reactions often occur at specific positions of the pyridine ring.
In addition, this compound has a wide range of uses in the field of organic synthesis and can be used as a key intermediate to prepare fine chemicals such as drugs, pesticides and functional materials through a series of reactions.

4-Iodine-pyridine-2-carboxylic acid, this substance has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. The structure of Gainpyridine and carboxyl groups endows it with unique chemical and biological activities, and can be chemically modified to interact with specific biological targets. For example, in the development of antibacterial drugs, this is the starting material. By derivatization of its iodine atom and carboxyl group, compounds with targeted antibacterial activity can be constructed, which is expected to solve the problem of specific bacterial infections.
In the field of materials science, 4-iodine-pyridine-2-carboxylic acids are also useful. It can be used as a ligand to complex with metal ions to prepare metal-organic framework materials (MOFs). Due to its high specific surface area and regular pore structure, this material exhibits excellent performance in gas adsorption and separation, catalysis, etc. For example, in the field of carbon dioxide capture, MOFs containing 4-iodine-pyridine-2-carboxylic acid ligands have high adsorption capacity for carbon dioxide, providing a potential solution for alleviating the greenhouse effect.
In organic synthetic chemistry, the iodine atom of 4-iodine-pyridine-2-carboxylic acid can participate in many coupling reactions, such as Suzuki coupling, Heck coupling, etc. Through these reactions, different functional groups can be introduced into molecules to build complex and diverse organic compounds, providing powerful tools for organic synthetic chemists to create new functional materials and bioactive molecules.

The synthesis method of 4-iodine-pyridine-2-carboxylic acid has been known for a long time, and there are many kinds. Here are several common ones for you.
First, pyridine-2-carboxylic acid is used as the starting material, and iodine atoms are introduced by halogenation reaction. This process requires careful selection of halogenating reagents, such as iodine elemental ($I_2 $) and appropriate oxidizing agents. Common oxidizing agents such as hydrogen peroxide ($H_2O_2 $), in acidic media, the two work together to iodize the 4-position of pyridine-2-carboxylic acid, and then form the target product. During the reaction, it is necessary to strictly control the reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions and lead to impure products.
Second, an appropriate pyridine derivative can also be used as the starting material and prepared by multi-step reaction. For example, a specific pyridine derivative is first introduced through a substitution reaction to introduce a suitable functional group, which needs to facilitate the subsequent introduction of iodine atoms and the construction of carboxyl groups. Subsequently, a series of reactions such as hydrolysis and oxidation are used to gradually build carboxyl groups, and iodine atoms are introduced at the 4-position at the same time. Although this method is slightly complicated, it can precisely control the reaction check point and improve the purity of the product.
Furthermore, the coupling reaction catalyzed by metal is also an effective way. The substrate containing the pyridine ring is selected, and the iodine substitution reagent is used to achieve the 4-position iodine substitution under the action of a metal catalyst such as palladium ($Pd $) catalyst, and the carboxyl group is constructed at the same time. In this process, the selection of ligands is crucial, and suitable ligands can enhance the activity and selectivity of the metal catalyst, and promote the efficient reaction.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to weigh and choose according to the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the product.

4-Iodopyridine-2-carboxylic acid is a chemical substance, and many things need to be paid attention to when storing and transporting.
Its nature or activity, in case of heat, open flame or oxidant, may cause violent reaction, so when storing, it should be placed in a cool and ventilated warehouse, away from fire and heat sources, and stored separately from oxidants, reducing agents, acids, alkalis, etc., and should not be mixed to prevent dangerous reactions caused by improper contact. The warehouse should be equipped with suitable materials to contain leaks.
When transporting, it should also abide by relevant regulations. Before transportation, be sure to pack completely to ensure that it is well sealed to prevent material leakage. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Transport vehicles should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. The route selection should also be careful to avoid passing through densely populated areas and traffic arteries, in case of leakage accidents, which can reduce the harm to the public. At the same time, transport personnel need to undergo professional training, familiar with the nature of the substance and emergency treatment methods to ensure the safety of the transportation process.

Fu 4-iodine-pyridine-2-carboxylic acid is one of the organic compounds. It is not easy to know its market price. The price of this acid often changes due to many factors, like changes in the wind and clouds, and it is elusive.
First, the cost of raw materials has a great impact. If the raw materials required for the production of this acid are difficult to obtain and the origin varies, the price will fluctuate. For example, if the raw materials are scarce and difficult to find, the price will be high; if the raw materials are abundant and widely available, the price will be cheap.
Second, the production process is also the key. Sophisticated and advanced technology can greatly increase production efficiency, reduce costs, and the price of its products may be close to the people; and if the process is complicated, it consumes a lot of manpower and material resources, and the cost is high, the price will rise.
Third, the supply and demand situation of the market, such as the invisible hand, determines its price. If the market has strong demand for 4-iodine-pyridine-2-carboxylic acid, the demand is greater than the supply, and the price will rise; if the demand is small, the supply exceeds the demand, and the price is at risk of falling.
Fourth, different suppliers set different prices due to factors such as their own operating costs and profit considerations. Or some suppliers want to seize the market at a low price, or they price higher because of excellent quality.
After checking the records of past transactions and market conditions, it is difficult to find an exact price. The price of this compound may fluctuate between a few yuan per gram and tens of yuan, but this is only a rough estimate and it is difficult to determine accurately. To know its current exact price, you need to consult major chemical product suppliers, or check in detail on professional chemical trading platforms to know a more accurate price.