4 Hydroxypyridine
pyridine pyrrole pyrazine piperidine piperazine

4-hydroxypyridine

    Specifications

    HS Code

    228927

    Name 4-hydroxypyridine
    Molecular Formula C5H5NO
    Molar Mass 95.10 g/mol
    Appearance White to off - white solid
    Odor Characteristic
    Melting Point 145 - 148 °C
    Boiling Point 273 - 275 °C
    Solubility In Water Soluble
    Pka 11.4
    Flash Point 158 °C
    Density 1.21 g/cm³

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    General Information
    Where to Buy 4-hydroxypyridine in China?
    As a trusted 4-hydroxypyridine manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-hydroxypyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-hydroxypyridine?
    4-Hydroxypyridine is widely used in the chemical industry and medicine.
    In the chemical industry, it is an important material for organic synthesis. It can be used to make a variety of materials with different functions. For example, after a specific reaction, it can form a polymer with excellent electrical conductivity, which is very useful in electronic devices such as organic Light Emitting Diode (OLED). OLED display screens, relying on this material, may make the display clearer and more colorful. And because of the characteristics of hydroxyl groups and pyridine rings in its structure, it can participate in many condensation and substitution reactions, paving the way for the synthesis of complex organic molecules, which is of great significance for the development of new materials.
    In medicine, 4-hydroxypyridine is also a key intermediate. The synthesis of many drugs is based on it. Due to its active chemical properties, it can introduce different functional groups, thereby adjusting the activity and selectivity of the drug. For example, some drugs with antibacterial and anti-inflammatory effects are often synthesized with 4-hydroxypyridine as the starting material. After modification, its structure is adapted to specific targets, so that it can accurately act on the focus and eliminate diseases for patients. And its research in pharmaceutical chemistry is also an important tool to help researchers understand the mechanism of drug action and develop new drugs with better efficacy and less side effects.
    Overall, 4-hydroxypyridine is used in the chemical and pharmaceutical industries like masonry in Guangsha, providing the foundation for building a complex and delicate chemical world and promoting various innovations and developments.
    What are the physical properties of 4-hydroxypyridine?
    4-Hydroxypyridine is a kind of organic compound. Its physical properties are quite impressive.
    First of all, under room temperature, 4-Hydroxypyridine is often white to light yellow crystalline powder, which is delicate and uniform in texture, as if carefully carved over time.
    When it comes to the melting point, the melting point of this substance is about 280 ° C - 284 ° C. The determination of the melting point is like giving it an accurate temperature scale. This property is like a shining guiding beacon in the process of identification and purification of compounds, providing a key basis for experimenters to accurately grasp the transformation of their physical state.
    In addition to its solubility, 4-hydroxypyridine is soluble in water. In water, its molecules are like agile dancers, blending with water molecules, showing unique dissolution properties. And in organic solvents such as ethanol and acetone, it can also be found in traces. Its solubility makes it able to travel freely in different chemical environments. In many fields such as organic synthesis, it plays an indispensable and important role, paving the way for the smooth progress of the reaction.
    Its smell is weak, not pungent, and there is no strong smell that disturbs people's sense of smell. It is like a humble gentleman, showing people in a gentle manner. 4-Hydroxypyridine has a moderate density, although it is not accurate to the millimeter. However, among similar compounds, it also plays an indispensable role in the vast stage of chemistry due to its unique physical properties.
    What are the chemical properties of 4-hydroxypyridine
    4-Hydroxypyridine is also an organic compound. Its unique properties are important in various fields of chemistry.
    In terms of its acidity and alkalinity, 4-Hydroxypyridine is amphoteric. Because the hydroxyl group can release protons, it is acidic; the nitrogen of the pyridine ring has solitary pairs of electrons, can hold protons, and is basic. This amphoteric characteristic makes it able to react with a variety of substances in an acid-base environment, or form salts, or participate in acid-base catalyzed reactions.
    In terms of solubility, 4-Hydroxypyridine is soluble in water and many organic solvents. Because of its hydroxyl group, it can form hydrogen bonds with water, so it has a certain solubility in water. And because of its hydrophobic pyridine ring, ethanol, acetone and other organic solvents can also be soluble, this solubility makes it in different reaction systems can be used as reactants or intermediates.
    Reactive activity is quite high. Hydroxyl groups can undergo esterification, etherification and other reactions. In case of acid chloride or anhydride, the oxygen atom of the hydroxyl group nucleophilic attack acyl carbons to form ester compounds, which is very important for organic synthesis of ester derivatives. Pyridine rings are also active and can undergo electrophilic substitution reactions under specific conditions. Various substituents are introduced with nitrogen atoms as the main reaction check points, thus enriching their chemical structure and expanding their application range. 4-Hydroxypyridine is an important basic raw material in the fields of medicine, pesticides, materials, etc. due to its own structural characteristics and the above chemical properties, which promotes the development of chemical synthesis and technology in various fields.
    What are the preparation methods of 4-hydroxypyridine?
    4-Hydroxypyridine is also an organic compound. Its preparation method has been studied by ancient alchemists. One method is to use pyridine as the starting material, make it co-heat with a strong oxidizing agent, and after oxidation, 4-hydroxypyridine can be obtained. However, this method requires careful use of strong oxidizing agents, because of its strong nature, easy to produce danger, and the yield may not be ideal.
    Another method uses 4-halogenated pyridine as the raw material to make it cowarm with the nucleophilic reagent in contact with water, and the halogen atom is replaced by a hydroxyl group to form 4-hydroxypyridine. The conditions of this method are relatively simple, but the raw material 4-halogenated pyridine is rare, and impurities are easy to form during the reaction, so it needs to be carefully controlled.
    Furthermore, using natural products containing pyridine rings as the source and chemically modified, 4-hydroxypyridine can also be prepared. However, the extraction of natural products may be limited by season and origin, and the extraction process is complicated and costly.
    The preparation process has its own advantages and disadvantages. It is necessary to obtain 4-hydroxypyridine according to various factors such as the ease of availability of raw materials, the difficulty of reaction, and the high and low cost. Only with caution can we obtain a good method to obtain 4-hydroxypyridine.
    What is the price range of 4-hydroxypyridine in the market?
    4-Hydroxypyridine is in the market, and its price range is difficult to determine. This causes its price to change for many reasons.
    The supply and demand of Guanfu City, if there are many people who want it and there are few people who supply it, the price will be higher; if the supply exceeds the demand, the price will go down. And the cost of its production, the price of raw materials, labor costs, energy consumption, etc., all affect its price. The price of raw materials is high, the production system is difficult, and the cost is high, and the price in the market is also high. Furthermore, the number of producers and the competition situation also have an impact. If there are many producers and the competition is intense, it is a competition for the market, or there is a price reduction; if there are few producers and they are almost monopolized, the price may be controllable and higher. < Br >
    I have heard that the price may be between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximate number, and it is not an exact value. To know the real-time price, when you consult the merchants of chemical materials, enter the market to explore the price, or check on the relevant business platform, you can get a more accurate price. When the market situation changes, the price is also uncertain, and it is only appropriate to check it from time to time.