4-Hydroxypyridine N-oxide

4-Hydroxypyridine-N-oxide is an organic compound. It has a wide range of uses and has important applications in many fields.
First, in the field of medicinal chemistry, it can be used as a key intermediate for drug synthesis. Due to its unique chemical structure and activity, it can construct complex drug molecular structures through various chemical reactions, laying the foundation for the development of new drugs. For example, in the development of certain antibacterial and anti-inflammatory drugs, 4-hydroxypyridine-N-oxide can participate in the reaction and give the drug specific pharmacological activity.
Second, in the field of materials science, it also has outstanding performance. It can be used to prepare functional materials, such as conductive polymer materials. Due to its structural characteristics, it can affect the electrical and optical properties of materials. After rational design and reaction, the material can have unique functions such as conductivity and luminescence, and has great potential for applications in electronic devices and optical displays.
Furthermore, in the field of organic synthetic chemistry, it is often used as a catalyst or ligand. With its ability to regulate reactivity and selectivity, it can effectively promote the progress of many organic reactions, improve reaction efficiency and product purity. For example, in some metal-catalyzed reactions, 4-hydroxypyridine-N-oxide can form specific complexes with metals, change the electron cloud density of the active center of the metal, and then precisely regulate the reaction process.

4-Hydroxypyridine-N-oxide is a kind of organic compound. Its physical properties are unique and it has the following characteristics.
First of all, its appearance is often white to light yellow crystalline powder, uniform and delicate. Looking at it, the color and shape of this substance are just like the frost powder that falls at the beginning of autumn, pure and rustic.
The melting point is between 195-198 ° C. When the temperature gradually rises, the substance is like ice and snow meeting warm sun, slowly melting from solid to liquid. This temperature range is the key node of its phase transition.
Furthermore, its solubility is also characteristic. In water, 4-hydroxypyridine-N-oxide can show a certain solubility, just like fine sand entering the flow, and can blend with water. And in organic solvents, such as methanol, ethanol and other common organic solvents, it also has considerable solubility, just like fish entering a river, it can be dispersed in it.
And its stability is also worth mentioning. Under normal environmental conditions, 4-hydroxypyridine-N-oxide is relatively stable and does not easily react with the surrounding objects. However, under extreme conditions such as high temperature, strong acid or strong alkali, its structure and properties may change, like a calm lake thrown into boulders, creating layers of waves.
In addition, the substance may have a certain polarity due to the specific atoms and chemical bonds in the molecular structure. This polarity affects its interaction with other substances and plays an indispensable role in chemical reactions and physical processes.
Viewing its physical properties can lay the foundation for exploring its chemical properties and practical applications, and has important reference value in many fields such as chemical industry and medicine.

The stability of the chemical properties of 4-hydroxypyridine-N-oxide is one of the important topics in chemical research. This compound has a unique structure. The hydroxyl group is connected to the pyridine ring, and the oxygen atom on the nitrogen atom forms an N-oxide state.
Looking at its structure, the pyridine ring is aromatic, giving it a certain stability. However, the presence of hydroxyl groups allows it to participate in a variety of chemical reactions. Hydroxyl groups are active functional groups and are prone to substitution reactions. If they interact with nucleophiles, the hydroxyl group can be replaced, which may affect its stability.
Furthermore, the N-oxide part also has a significant impact on its properties. In N-oxides, nitrogen-oxygen bonds have polarity, which can enhance the polarity of molecules, thereby affecting their solubility and other physical properties. And this structure changes the electron cloud distribution of the pyridine ring, affecting the electrophilic substitution reactivity on the ring.
In terms of stability, due to the possibility of forming hydrogen bonds in the molecule, if the hydroxyl group forms an intramolecular hydrogen bond with the oxygen atom of N-oxide, the stability of the molecule can be enhanced. However, under certain conditions, such as strong acids or strong bases, its structure may be affected. In strong acids, N-oxides are partially or protonated, changing the charge distribution and reactivity of molecules; in strong bases, hydroxyl groups may be deprotonated, triggering subsequent chemical reactions, affecting their stability.
In summary, the stability of 4-hydroxypyridine-N-oxide is not absolute, and it is closely related to the chemical environment in which it is located. Under different conditions, its stability will change.

There are several methods for synthesizing 4-hydroxypyridine-N-oxide.
First, pyridine-N-oxide is used as the starting material. Pyridine-N-oxide reacts with appropriate acylating reagents, such as acetic anhydride, at suitable temperatures and reaction conditions to form an acyloxypyridine-N-oxide intermediate. This intermediate is then hydrolyzed through a step of hydrolysis. Under the catalysis of acid or base, the acyloxy group is hydrolyzed to hydroxyl groups to obtain 4-hydroxypyridine-N-oxide. The advantage of this path is that the starting material pyridine-N-oxide is relatively easy to obtain, and the reaction steps are relatively clear. However, the acylation and hydrolysis process requires precise control of the reaction conditions to ensure yield and purity.
Second, you can start from 4-halopyridine-N-oxide. 4-halopyridine-N-oxide (halogen atoms can be chlorine, bromine, etc.) reacts with nucleophiles, such as alkali metal hydroxides (such as sodium hydroxide), in suitable solvents (such as polar aprotic solvents such as dimethyl sulfoxide), at appropriate temperatures. The halogen atoms are replaced by hydroxyl nucleophiles to form 4-hydroxypyridine-N-oxide. The advantage of this method is that nucleophilic substitution reactions are relatively common and the conditions are relatively mild. However, attention should be paid to the preparation and separation of halogenated pyridine-N-oxide to ensure the smooth progress of the reaction.
Third, 4-methoxypyridine-N-oxide is used as raw material. The synthesis of the target product is achieved through demethylation reaction. Commonly used demethylating reagents such as boron tribromide react with 4-methoxypyridine-N-oxide at low temperature and without water. Boron tribromide interacts with the methoxy group to remove the methoxy group to form 4-hydroxypyridine-N-oxide. Although this method can efficiently demethylate, boron tribromide is highly corrosive, and extra caution is required during operation and post-reaction treatment to prevent product loss or introduction of impurities.
Each method for synthesizing 4-hydroxypyridine-N-oxide has its own advantages and disadvantages. In practical application, the appropriate synthesis path needs to be comprehensively selected according to many factors such as the availability of raw materials, the difficulty of controlling reaction conditions, and cost considerations.

The market price of 4-hydroxypyridine-N-oxide varies for many reasons. Its price is related to quality, purity, mass production scale, supply and demand situation, and changes with the market.
If looking at the market conditions in the past, those with high quality and high purity may have higher prices. In areas with strict purity requirements such as fine chemicals and pharmaceutical research and development, high-purity 4-hydroxypyridine-N-oxide is quite popular, and the price is correspondingly higher.
Mass production scale is also a major factor. If a factory can mass-produce, with economies of scale, the unit cost may drop, and the market price may be more affordable. On the contrary, small-scale production, the cost is difficult to reduce, and the price is easy to increase.
The situation of supply and demand also affects its price. When the market demand for this product is strong, but the supply is limited, the price will rise. If the demand is low, the supply exceeds the demand, the price may drop.
In the past, its price may fluctuate within a certain range. If you want to know the exact current price, you should consult chemical product suppliers, traders, or refer to the quotation of professional chemical product trading platforms. Because the market situation is changing rapidly, real-time information is the way to get accurate prices.